Participants with a high (LE8) score had a 47% lower risk of -related surgery and all-cause mortality compared to those with a low LE8 score.
A total of 282 IBD-related surgeries and 259 deaths were recorded over a mean follow-up of 12.60 years.
In ulcerative colitis patients, a high LE8 score is associated with a decreased risk of IBD-related surgery and all-cause mortality.
The hazard ratios for ulcerative colitis patients with a high LE8 score were 0.47 for both IBD-related surgery and all-cause mortality.
No significant associations were found between LE8 score and adverse outcomes in Crohn's disease patients.
Simplified
BACKGROUND: Previous studies indicated discrete lifestyle health metrics that benefit cardiovascular health are associated with better prognosis in (IBD), while evidence regarding the comprehensive impact of cardiovascular health remains limited. This study aimed to investigate the association between the overall cardiovascular health indicator, (LE8), and the adverse outcomes of IBD.
MATERIALS AND METHODS: We included 3232 IBD participants recruited from the UK Biobank between 2006 and 2010. LE8 encompasses 8 metrics, including physical activity, diet, sleep health, nicotine exposure, body mass index, blood glucose, blood lipids, and blood pressure. The adverse outcomes studied in our study included IBD-related surgery and all-cause mortality. Hazard ratios (HRs) with 95% confidence intervals (CIs) for the strength of the associations between LE8 score and IBD-related surgery as well as all-cause mortality were calculated using Cox proportional hazard models.
RESULTS: Over a mean (standard deviation) follow-up of 12.60 (2.74) years and 13.17 (1.89) years, 282 IBD-related surgery and 259 death events were recorded. Ulcerative colitis (UC) patients with a high LE8 score showed decreased risk of IBD-related surgery (HR 0.47, 95% CI 0.26, 0.87) and all-cause mortality (HR 0.47, 95% CI 0.25, 0.87), in comparison to those with a low LE8 score. No significant associations were observed between LE8 score and the risk of IBD-related surgery and all-cause mortality among Crohn's disease (CD) in the primary analyses.
CONCLUSION: Participants with a higher LE8 score showed decreased risk of IBD-related surgery and all-cause mortality among UC, but not CD, underscoring the significance of implementing LE8 as a management approach in improving the prognosis of UC.
Key numbers
0.47
Decrease in Surgery and Mortality Risk
Hazard ratio for -related surgery and all-cause mortality in UC patients.
3232
Study Population Size
Total number of participants with in the study.
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