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Risk of Incident Diabetes and Cardiovascular Diseases: Prevention Opportunities With the American Heart Association’s Life’s Essential 8 in Individuals With Prediabetes Bearing Different Genetic Predisposition
Risk of New Diabetes and Heart Disease in People with Prediabetes and Different Genetic Risks, and Prevention Using the American Heart Association’s Life's Essential 8
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Abstract
Higher cardiovascular health scores were linked to a lower risk of new-onset type 2 diabetes and cardiovascular diseases among 26,962 individuals with prediabetes.
- A higher score on Life's Essential 8 was associated with a reduced risk of adverse outcomes, with hazard ratios ranging from 0.26 to 0.72.
- Each 1-point increase in the LE8 score corresponded to a decreased risk of incident type 2 diabetes and cardiovascular diseases, with hazard ratios between 0.97 and 0.99.
- Low LE8 scores were attributed to a significant proportion of new cases, with 70.47% of incident type 2 diabetes and 45.12% of cardiovascular disease cases linked to this factor.
- A higher polygenic risk score was associated with an increased risk of adverse outcomes, with hazard ratios ranging from 1.38 to 3.68.
- Individuals with low polygenic risk scores experienced greater benefits from high adherence to cardiovascular health metrics in relation to new-onset type 2 diabetes.
- Body mass index, blood pressure, and nicotine exposure were identified as the most significant contributors to the onset of type 2 diabetes and cardiovascular diseases in the prediabetes stage.
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