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Mammalian-Microbial Cometabolism of L -Carnitine in the Context of Atherosclerosis
How Mammals and Gut Bacteria Work Together to Process L-Carnitine in Relation to Artery Disease
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Abstract
γ-butyrobetaine is identified as a major metabolite of L-carnitine breakdown by gut bacteria.
- L-carnitine is known to be synthesized from γ-butyrobetaine in the body.
- Gut bacteria degrade L-carnitine, producing γ-butyrobetaine as a significant byproduct.
- The degradation process of L-carnitine by gut bacteria occurs before the formation of trimethylamine and trimethylamine-N-oxide.
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