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Determination of trimethylamine‐N‐oxide in combination with l‐carnitine and γ‐butyrobetaine in human plasma by UPLC/MS/MS
Measuring trimethylamine-N-oxide, L-carnitine, and γ-butyrobetaine levels in human blood plasma
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Abstract
An ultra-high-performance liquid chromatography-mass spectrometry method was validated for quantifying trimethylamine-N-oxide (TMAO) and related molecules in human blood plasma.
- The method allows simultaneous measurement of TMAO, L-carnitine, and γ-butyrobetaine in plasma samples.
- Quantification of TMAO was validated following US Food and Drug Administration guidelines.
- The technique was successfully applied to plasma samples from healthy volunteers.
- TMAO and its related molecules are of interest due to their potential implications in health.
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