Melatonin inhibits spontaneous and VIP-induced vasopressin release from suprachiasmatic neurons

Sep 5, 1998Brain research

Melatonin reduces natural and VIP-stimulated vasopressin release from brain's internal clock neurons

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Abstract

Melatonin inhibits vasopressin release induced by vasoactive intestinal peptide with an EC50 of 0.4 nM.

  • Vasopressin release from rat suprachiasmatic nuclei follows a circadian rhythm, peaking during the day and decreasing at night.
  • Melatonin decreases the spontaneous increase in vasopressin release and accelerates its decrease.
  • The inhibition of vasopressin release by melatonin is linked to its known effect on reducing spontaneous neuronal activity in the suprachiasmatic nuclei.

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