The microbiota drives diurnal rhythms in tryptophan metabolism in the stressed gut

Apr 13, 2024Cell reports

Gut bacteria influence daily cycles of tryptophan processing in a stressed digestive system

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Abstract

A 15-minute acute stressor significantly affects tryptophan metabolism in mice.

  • Acute stress is linked to changes in gut barrier function and tryptophan metabolism.
  • Microbial species that show rhythmic activity are involved in tryptophan metabolism.
  • The response of the gastrointestinal system to stress varies depending on the time of day.
  • Stress-induced changes were observed specifically in the ileum and colon regions.

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