Microbiota-gut brain axis involvement in neuropsychiatric disorders

Jul 2, 2019Expert review of neurotherapeutics

The role of gut bacteria and their communication with the brain in mental health disorders

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Abstract

The gut microbiota may influence neuropsychiatric health through the microbiota-gut brain axis.

There is evidence linking changes in gut microbiota composition and function to neuropsychiatric disorders.
Preclinical studies suggest that gut microbiota can affect behaviors relevant to psychiatry and central nervous system conditions.
Exploration of the microbiota-gut brain axis could lead to new treatment strategies for central nervous system disorders.
Identifying biomarkers related to gut microbiota may facilitate early diagnosis and improved treatment options.

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: The microbiota-gut brain (MGB) axis is the bidirectional communication between the intestinal microbiota and the brain. An increasing body of preclinical and clinical evidence has revealed that the gut microbial ecosystem can affect neuropsychiatric health. However, there is still a need of further studies to elucidate the complex gene-environment interactions and the role of the MGB axis in neuropsychiatric diseases, with the aim of identifying biomarkers and new therapeutic targets, to allow early diagnosis and improving treatments.: To review the role of MGB axis in neuropsychiatric disorders, prediction and prevention of disease through exploitation, integration, and combination of data from existing gut microbiome/microbiota projects and appropriate other International '-Omics' studies. The authors also evaluated the new technological advances to investigate and modulate, through nutritional and other interventions, the gut microbiota.: The clinical studies have documented an association between alterations in gut microbiota composition and/or function, whereas the preclinical studies support a role for the gut microbiota in impacting behaviors which are of relevance to psychiatry and other central nervous system (CNS) disorders. Targeting MGB axis could be an additional approach for treating CNS disorders and all conditions in which alterations of the gut microbiota are involved. Introduction Areas covered Expert opinion

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Microbiota-gut brain axis involvement in neuropsychiatric disorders

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