Mulberry leaf polysaccharides ameliorate glucose and lipid metabolism disorders via the gut microbiota-bile acids metabolic pathway

Mulberry leaf polysaccharides (MLP) reduced fasting blood glucose and lipid levels in Type 2 Diabetes Mellitus (T2DM) rats.

• MLP improved glucose and lipid metabolism and decreased insulin resistance.
• The treatment increased the abundance of beneficial gut bacteria, including Prevotella, Ruminococcus, and Lactobacillus.
• MLP altered bile acid metabolism, indicated by reduced serum cholesterol and increased expression of specific liver enzymes.
• The expression of receptors involved in bile acid signaling was modulated by MLP in the liver and ileum of T2DM rats.
• These findings indicate that MLP may help restore gut microbiota balance and support metabolic health in T2DM.

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