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Neonatal rat cardiomyocytes as an in vitro model for circadian rhythms in the heart
Using newborn rat heart cells grown in the lab to study daily rhythms in the heart
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Abstract
Neonatal rat cardiomyocytes exhibit anti-phasic oscillatory mRNA expression of core clock genes Bmal1 and Per2, mimicking in vivo circadian rhythmicity.
- A novel in vitro model demonstrates the circadian rhythms in heart cells.
- Oscillations in apoptosis responses to doxorubicin, hydroperoxide, or hypoxia indicate functional dependence on circadian regulation.
- Chemical perturbations, such as Resveratrol and Ex-527, disrupt functional rhythmicity in the cardiomyocytes.
- This model may facilitate investigations into the cardiac circadian clock and the effects of various compounds on cardiac health.
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