Oleic acid restores the rhythmicity of the disrupted circadian rhythm found in gastrointestinal explants from patients with morbid obesity

Feb 3, 2021Clinical nutrition (Edinburgh, Scotland)

Oleic acid helps reset the disrupted daily rhythm in gut tissue from severely obese patients

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Abstract

Oleic acid (OA) restored rhythmicity in key circadian rhythm genes in stomach and jejunum explants from patients with morbid obesity.

  • Stomach explants exhibited an altered circadian rhythm in several clock genes, including CLOCK and BMAL1.
  • OA treatment led to the emergence of rhythmicity in PER1, PER2, PER3, and ghrelin in stomach explants.
  • Jejunum explants showed an altered circadian rhythm in CLOCK, BMAL1, PER1, and PER3.
  • OA restored rhythmicity in PER2, REVERBα, CRY1, and GLP1 in jejunum explants, with no effect on CRY2.
  • OA increased the amplitude of circadian rhythm genes in both stomach and jejunum explants.

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