Role of physical exercise on hepatic insulin, glucocorticoid and inflammatory signaling pathways in an animal model of non-alcoholic steatohepatitis

Endurance training improved insulin sensitivity in both standard and high-fat diet conditions.

• High-fat diet increased levels of pro-inflammatory markers interleukin-1β, interleukin-6, and TGF-β, which were reduced by physical exercise.
• Physical exercise decreased levels of leukemia inhibitory factor in the high-fat diet group compared to the standard diet group.
• High-fat diet raised the ratio of a specific insulin signaling protein, which was completely mitigated by physical exercise.
• Exercise reduced total and activated levels of certain signaling proteins associated with inflammation in the high-fat diet group.
• In both diet groups, exercise led to a decrease in specific glucocorticoid-regulating enzymes.

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