Physical exercise antagonizes clinical and anatomical features characterizing Lieber-DeCarli diet-induced obesity and related metabolic disorders

At 17 weeks, high-fat diet increased visceral adiposity, which was counteracted by both voluntary physical activity and endurance training.

• Endurance training was the only intervention that significantly reduced obesity-related measures and improved histological features of non-alcoholic steatohepatitis (NASH).
• Blood analysis after 9 weeks indicated that a high-fat diet raised levels of liver enzymes (ALT, AST), cholesterol, and HDL while decreasing VLDL and triglycerides.
• The positive effects of voluntary physical activity on blood parameters were temporary and not sustained by the 17-week mark.
• The Lieber-DeCarli diet model induced obesity and metabolic changes in Sprague-Dawley rats, providing insight into the effects of diet and exercise.

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