Endocrinology

Physical and inflammatory stress increase daily rhythm gene mPer1 levels in the mouse's stress-control brain area

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Forced swimming, immobilization, and lipopolysaccharide injection elevated mPer1 gene expression in the paraventricular nucleus (PVN).

  • Stress induces secretion of corticosterone through the activation of the hypothalamic-pituitary-adrenal axis.
  • Corticosterone secretion is thought to be regulated by a circadian clock located in the suprachiasmatic nucleus (SCN).
  • The PVN integrates signals from both stress and the circadian clock.
  • mPer1 gene expression increased specifically in the PVN in response to physical and inflammatory stressors.
  • No changes in mPer2 expression were detected in the PVN, SCN, or liver following the stressors.
  • The findings suggest that stress may disrupt circadian corticosterone secretion through increased mPer1 expression in the PVN.

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