REV-Erbα as a Gene Controller Connecting Body Clock, Metabolism, and Inflammation

REV-ERBα may be a promising target for addressing changes in metabolic pathways and inflammation within the circadian rhythm.

• REV-ERBα regulates genes associated with circadian rhythm, metabolism, and inflammation.
• Circadian disruption is linked to persistent inflammation and chronic inflammatory complications, such as muscle wasting.
• Muscle wasting results from an imbalance between energy metabolism and anabolic catabolism.
• Disruption of circadian and metabolic homeostasis is associated with an increasing incidence of inflammatory disorders.
• Clarifying the intersection of the circadian clock and REV-ERBα with immune functions is essential for understanding immune system dynamics.

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