Sex differences in the association between ideal cardiovascular health and biomarkers of cardiovascular disease among adults in the United States: a cross-sectional analysis from the multiethnic study of atherosclerosis

Nov 28, 2019BMJ open

How ideal heart health relates to heart disease markers differs between men and women in US adults

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Higher cardiovascular health scores were associated with lower concentrations of all studied cardiovascular disease-related biomarkers except for NT-proBNP.

The study involved 5,379 participants aged 45-84 years, including 52% women and a diverse ethnic representation.
Cardiovascular health was measured using the American Heart Association's Life's Simple 7 metrics, scoring a total from 0 to 14.
All biomarkers studied showed lower levels with higher cardiovascular health scores, indicating potential risks related to cardiovascular disease.
Statistically significant interactions by sex were found for all biomarkers, suggesting differences in associations may exist between women and men.
Results indicate that promoting ideal cardiovascular health may similarly reduce cardiovascular disease risk biomarkers for both sexes.

AI simplified

OBJECTIVES: This study investigated the sex differences in the associations between ideal cardiovascular health (CVH), measured by the American Heart Association's Life's Simple 7 metrics, and cardiovascular disease (CVD)-related biomarkers among an ethnically diverse cohort of women and men free of clinical CVD at baseline.

SETTING: We analysed data from the Multi-Ethnic Study of Atherosclerosis conducted in six centres across the USA (Baltimore, Maryland; Chicago, Illinois; Forsyth County, North Carolina; Los Angeles, California; New York, New York; and St Paul, Minnesota).

PARTICIPANTS: This is a cross-sectional study of 5379 women and men, aged 45-84 years old. Mean age (SD) was 62 (10), 52% were women, 38% White, 11% Chinese American, 28% Black and 23% Hispanic.

PRIMARY MEASURES: The seven metrics (smoking, body mass index, physical activity, diet, total cholesterol, blood pressure and blood glucose) were each scored as 0 points (poor), 1 point (intermediate) or 2 points (ideal). The total CVH score ranged from 0 to 14. The CVD-related biomarkers studied were high-sensitivity C-reactive protein, D-dimer, fibrinogen, homocysteine, high-sensitivity cardiac troponin T, N-terminal pro B-type natriuretic peptide (NT-proBNP) and interleukin 6. We examined the association between the CVH score and each biomarker using multivariable linear regression, adjusting for age, race/ethnicity, education, income and health insurance status.

RESULTS: Higher CVH scores were associated with lower concentrations of all biomarkers, except for NT-proBNP where we found a direct association. There were statistically significant interactions by sex for all biomarkers (p<0.001), but results were qualitatively similar between women and men.

CONCLUSION: A more favourable CVH score was associated with lower levels of multiple CVD-related biomarkers for women and men, except for NT-proBNP. These data suggest that promotion of ideal CVH would have similarly favourable impact on the reduction of biomarkers of CVD risk for both women and men.

Full Text

We can’t show the full text here under this license. Use the link below to read it at the source.

View full text ↗

Sex differences in the association between ideal cardiovascular health and biomarkers of cardiovascular disease among adults in the United States: a cross-sectional analysis from the multiethnic study of atherosclerosis

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief