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Abstract
Sleep disorders affect approximately 27% of the global population.
- The gut-brain axis may play a significant role in regulating sleep through microbial metabolites.
- C. elegans serves as an effective model for studying the fundamental processes of sleep due to its simple nervous system and genetic adaptability.
- High-throughput behavioral phenotyping and calcium imaging techniques can be utilized to investigate sleep modulation related to gut microbiota.
- The review summarizes conserved molecular mechanisms linked to sleep, providing insights into the interactions between gut microbiota and sleep pathways.
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