Statin-induced gut dysbiosis and sleep disturbances: Mechanistic insights into microbiota–brain–circadian interactions and chronotherapeutic implications

Statins may be associated with sleep disturbances including insomnia and altered sleep quality.

• Clinical and experimental evidence suggests that statin therapy could disrupt sleep architecture and reduce overall sleep quality.
• The gut microbiota may play a critical role in regulating sleep through pathways involving serotonin and melatonin.
• Statins have been shown to alter gut microbial composition, potentially reducing beneficial bacteria that produce short-chain fatty acids.
• Changes in gut bacteria caused by statins may disrupt neurochemical signaling related to sleep regulation.
• The review discusses the implications of these findings for vulnerable populations, such as shift workers.
• Potential strategies, including probiotics and dietary changes, are proposed to address statin-related sleep disturbances.

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