The circadian clock network in the brain of different Drosophila species

The clock network organization is highly conserved among 10 Drosophila species.

• Both subgenera Sophophora and Drosophila exhibit similar lateral and dorsal clock neuron clusters as seen in Drosophila melanogaster.
• Species-specific differences in clock gene expression were observed, particularly in CRY and PDF.
• All species from the Drosophila subgenus and D. pseudoobscura lack CRY in large ventrolateral clock neurons.
• Reduced PDF immunostaining was found in small ventrolateral clock neurons across these species.
• The expression of the ion transport peptide (ITP) was consistent in specific small ventrolateral and dorsolateral clock neurons across all species.

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