The circadian disruption of night work alters gut microbiota consistent with elevated risk for future metabolic and gastrointestinal pathology

Jul 1, 2020Chronobiology international

Night work disrupts body clock and changes gut bacteria linked to higher risk of metabolism and digestive problems

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Abstract

The relative abundances of Bacteroidetes were reduced and those of Actinobacteria and Firmicutes increased when comparing night shift work to day shift work.

Fecal samples from 10 male security officers were analyzed after both day and night shifts.
A total of 20 stool samples were collected and analyzed for gut microbiota composition.
Changes in gut microbiota were observed, with specific bacteria linked to different shift types.
Rotational shift work is associated with disturbances in circadian rhythms.
Alterations in gut microbiota may be linked to an increased risk of metabolic syndrome and gastrointestinal issues.

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Day and night cycles are the most important cue for the central clock of human beings, and they are also important for the gut clock. The aim of the study is to determine the differences in the gut microbiota of rotational shift workers when working the day versus night shift. Fecal samples and other data were collected from 10 volunteer male security officers after 4 weeks of day shift work (07:00-15:00 h) and also after 2 weeks of night shift work (23:00-07:00 h). In total, 20 stool samples were collected for analysis of gut microbiota (10 subjects x 2 work shifts) and stored at -80°C until analysis by 16 S rRNA sequencing. The relative abundances of Bacteroidetes were reduced and those of Actinobacteria and Firmicutes increased when working the night compared to day shift.abundance was found to be a biomarker of the day shift work.andwere significantly more abundant in individuals when working the night shift. Rotational day and night shift work causes circadian rhythm disturbance with an associated alteration in the abundances of gut microbiota, leading to the concern that such induced alteration of gut microbiota may at least partially contribute to an increased risk of future metabolic syndrome and gastrointestinal pathology. Faecalibacterium Dorea longicatena Dorea formicigenerans

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The circadian disruption of night work alters gut microbiota consistent with elevated risk for future metabolic and gastrointestinal pathology

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