Pupil responses controlled by light-sensitive eye cells in young adults with vision problems

A significant decrease in pupil response was observed, with lower 6 s and 30 s PIPR values for blue light compared to red light (p < 0.001).

• The post-illumination pupil response (PIPR) is used to measure activity in intrinsically photosensitive retinal ganglion cells (ipRGCs).
• A strong response from ipRGCs was indicated by larger early and late area under the curve (AUC) values for 1 s blue light compared to red light (p < 0.001).
• Longer blue light exposure (5 s) resulted in a slightly stronger melanopsin response than shorter exposure (1 s).
• No significant differences in PIPR metrics were found between myopic and non-myopic participants (p > 0.05).
• Previous findings that refractive error does not affect PIPR were confirmed.

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