Cell

The VPAC2 receptor is essential for daily rhythm control in the mouse brain’s internal clock

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Mice lacking the VPAC(2) receptor for VIP and PACAP exhibit disrupted circadian rhythms.

  • These mice do not maintain normal patterns of rest and activity.
  • Circadian expression of core clock genes, including mPer1, mPer2, and mCry1, is absent in these mutants.
  • The mutants also fail to show the expected increase in mPer1 and mPer2 levels when exposed to light at night.
  • Findings suggest that signaling between cells using neuropeptides is crucial for sustaining circadian rhythms in the suprachiasmatic nuclei.

Simplified

Full Text

Full text is available at the source.
View Full Text ↗

Related papers

Mar '03
Peptide signals play a key role in controlling the body's daily rhythms in the brain's clock center
top 20% journal
cited by 59 papers
research support, non-u.s. gov't
Oct '02
Removing mCry2 restores daily rhythms in mice with a faulty mPer2 gene
top 2% journal
cited by 101 papers
research support, non-u.s. gov't
May '04
Daily and internal clock patterns of brain signaling molecules in night-active and day-active rodents
cited by 120 papers
comparative study
Apr '01
How the internal biological clock works in cultured skin cells
top 1% journal
cited by 386 papers
research support, non-u.s. gov't
Dec '01
Daily patterns of Per gene activity in key brain and pineal areas of aged rats
top 20% journal
cited by 133 papers
research support, non-u.s. gov't
Feb '03
Using a new genetic tool to study daily rhythm control in the mouse brain’s clock center
top 20% journal
cited by 17 papers
comparative study
Jun '00
Two feedback loops control the mammal biological clock
top 1% journal
cited by 9 papers
comment
May '00
Molecular feedback loops working together in the mammal's internal daily clock
top 1% journal
cited by 1,144 papers
research support, u.s. gov't, p.h.s.
Aug '03
Daily changes in biological clock gene activity in mice lacking normal daily behavior rhythms
top 30% journal
cited by 16 papers
research support, non-u.s. gov't

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #50
Afternoon workouts beat morning sessions for fat loss — and your genes may explain why
6 days ago7 studies
issue #49
Your body clock controls which drugs work — and a protein called gp78 is why
1 week ago7 studies
issue #48
A blood test can now estimate your internal clock time using just 60 proteins
2 weeks ago7 studies
issue #47
Your body clock controls liver fibrosis — and scientists just found the on/off switch
3 weeks ago7 studies
issue #46
Night shift workers' metabolomes fall out of sync — and glucose pays the price
4 weeks ago7 studies
issue #45
80% of FDA-approved drug targets show clock-dependent activity — timing may be everything
5 weeks ago7 studies
issue #44
Sleeping late on weekends is independently linked to higher cardiovascular disease risk
6 weeks ago7 studies
issue #43
A smartphone app cut mood episode recurrence 3.4x in people with depression and bipolar disorder
7 weeks ago7 studies
issue #42
Morning cancer immunotherapy linked to 49% vs 40% disease control rate in 969 patients
8 weeks ago7 studies
issue #41
Timing cancer treatment before 3pm nearly doubled survival in lung cancer patients
9 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief