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The VPAC2 Receptor Is Essential for Circadian Function in the Mouse Suprachiasmatic Nuclei
The VPAC2 receptor is essential for daily rhythm control in the mouse brain’s internal clock
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Abstract
Mice lacking the VPAC(2) receptor for VIP and PACAP exhibit disrupted circadian rhythms.
- These mice do not maintain normal patterns of rest and activity.
- Circadian expression of core clock genes, including mPer1, mPer2, and mCry1, is absent in these mutants.
- The mutants also fail to show the expected increase in mPer1 and mPer2 levels when exposed to light at night.
- Findings suggest that signaling between cells using neuropeptides is crucial for sustaining circadian rhythms in the suprachiasmatic nuclei.
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