International journal of biological macromoleculesJan 22, 2025

A water-soluble fiber from finger citron improves diabetes in mice by affecting gut bacteria and hormone signaling

GLP-1 Therapies Weekly Brief ↗PubMed ↗DOI ↗

Updated Jan 20, 2026

Abstract

FCP-2-1 significantly alleviated diabetic symptoms in diabetic mice.

FCP-2-1 restored the balance of gut microbiota in high-fat diet and streptozotocin-induced diabetic mice.
The content of short-chain fatty acids, specifically acetic acid and propionic acid, increased with FCP-2-1 treatment.
FCP-2-1 promoted the secretion of glucagon-like peptide-1 (GLP-1), which is a potential therapeutic target for diabetes.
Both FCP-2-1 and propionic acid stimulated GLP-1 secretion in specific human intestinal cells.
The antidiabetic effect of FCP-2-1 may be associated with the gut microbiota-GLP-1 pathway.

Simplified

FCP-2-1, a water-soluble polysaccharide isolated and purified from Finger Citron, demonstrated hypoglycemic effect in vitro in our previous study. However, its antidiabetic effect and underlying mechanism in vivo remain to be elucidated. In this study, the antidiabetic effect of FCP-2-1 and its effects on the gut microbiota, short-chain fatty acids (SCFAs), and glucagon-like peptide-1 (GLP-1) in high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic mice were investigated. The results showed that FCP-2-1 could significantly alleviate diabetic symptoms in diabetic mice, restore the balance of the gut microbiota, and increase the content of acetic acid and propionic acid. In particular, FCP-2-1 was found to be able to promote the secretion of GLP-1, a new therapeutic target for diabetes. Moreover, propionic acid and FCP-2-1 were able to promote GLP-1 secretion in NCI-H716 cells, suggesting that FCP-2-1 could stimulate the secretion of GLP-1 through itself and propionic acid produced by the gut microbiota. These findings indicated that the antidiabetic mechanism of FCP-2-1 might be related to the gut microbiota-GLP-1 pathway.

Full Text

Full text is available at the source.

View Full Text ↗

Funding

Competing interests

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

PubMed

A water-soluble fiber from finger citron improves diabetes in mice by affecting gut bacteria and hormone signaling

Abstract

Full Text

Funding

Competing interests

You found one interesting study. We’ll send the next 7.

What Lands in Your Inbox Each Week:

Recent issues from the glp-1 therapies brief

Abstract

Full Text

Funding

Competing interests

Related papers

You found one interesting study. We’ll send the next 7.

What Lands in Your Inbox Each Week:

Recent issues from the glp-1 therapies brief