When Weight Loss Becomes Harmful: Ketoacidosis Linked to Tirzepatide in a Woman Without Diabetes

A woman in her early 30s developed serious metabolic complications, including ketoacidosis, after her first tirzepatide injection.

• Persistent vomiting, epigastric pain, and fatigue were reported six days post-injection.
• Laboratory tests indicated mild hypoglycemia and high-anion-gap metabolic acidosis with elevated ketone levels.
• The patient required emergency treatment and was admitted to the intensive care unit for further management.
• Recovery occurred within 48 hours following administration of intravenous fluids, electrolytes, dextrose, and insulin.
• This case underscores the importance of recognizing potential life-threatening complications associated with dual incretin receptor agonists.

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