Relaxant effect induced by wogonin fromScutellaria baicalensison rat isolated uterine smooth muscle

Wogonin reduced the contractile amplitude of isolated rat uterine strips by 50% at a concentration of 60.5 μM.

• Wogonin exhibited a dose-dependent relaxant effect on spontaneous uterine contractions.
• The compound also inhibited contractions induced by oxytocin, prostaglandin F(2α), and acetylcholine.
• In Ca²⁺-free solution and following potassium depolarization, wogonin relaxed induced uterine contractions.
• The relaxant effect of wogonin may involve the inhibition of calcium entry into cells and the release of calcium from intracellular stores.
• The effects were partly blocked by specific potassium channel inhibitors, suggesting involvement of certain potassium channels.

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