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Pro: Alzheimer's disease and circadian dysfunction: chicken or egg?
Alzheimer’s disease and daily body clock problems: which comes first?
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Abstract
Circadian dysfunction is a prominent feature of Alzheimer's disease (AD) that may exacerbate its pathology.
- Circadian disruption is traditionally seen as a symptom of AD but may actually worsen the disease.
- Both human and animal studies indicate a link between sleep, circadian rhythms, and amyloid deposition.
- Increased amyloid-beta (Aβ) levels have been observed in sleep-deprived mice.
- Conditions such as sleep apnea and insomnia in humans may be associated with AD.
- Melatonin, which regulates circadian rhythms, is dysregulated in AD and could protect against toxic Aβ.
- Further studies are needed to understand how the circadian system impacts the development of AD.
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