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Gut microbiota and circadian disruption in humans: Is there a rationale for metabolic disorders?
Gut bacteria and disrupted daily rhythms in people: Possible links to metabolism problems
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Abstract
Circadian disruption is associated with metabolic disorders such as obesity and type 2 diabetes.
- Circadian disruption can arise from behaviors like shift work and sleep deprivation.
- The gut microbiome produces metabolites that influence nutrient absorption and metabolism in alignment with circadian rhythms.
- Preclinical studies show that circadian disruptions change microbial composition, reduce rhythmicity, and impair functionality.
- Human studies reveal inconsistent findings, suggesting that microbial functionality may be more sensitive to disruptions than microbial composition.
- Eating patterns can influence both the gut microbiome and circadian alignment, indicating potential for realignment to support metabolic health.
- Future research should utilize advanced methods to study the dynamic activity of the gut microbiome in response to circadian disruptors.
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