Modulation of complex coordinated molecular signaling by 5HT and a cocktail of inhibitors leads to ovarian maturation of Penaeus monodon in captivity

The combination of 5HT and specific inhibitors enhances ovarian maturation in Penaeus monodon, leading to higher quality and quantity of larvae compared to traditional eyestalk ablation.

• Limited domesticated broodstock availability affects P. monodon production due to its reproductive cycle.
• Unilateral eyestalk ablation induces ovary development but is associated with high mortality rates.
• Inhibition of a specific signaling pathway by U0126 reduces the vitellogenesis-inhibiting hormone, promoting vitellogenin production.
• 5HT activates a signaling pathway that stimulates the production of estradiol-17β, which is essential for ovarian maturation.
• The inhibitors used can stabilize the maturation-promoting factor complex, facilitating the transition from previtellogenic to matured oocytes.

AI simplified