Physical activity and meal timing alignment with chronotype and their associations with glucose metabolism: The Maastricht Study

Feb 4, 2026Diabetes, obesity & metabolism

How matching physical activity and meal times to your natural sleep-wake pattern relates to blood sugar control

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗OA ↗

Abstract

Alignment of physical activity timing with on weekdays is associated with a 0.48% lower per 20% increase in alignment.

Weekday alignment of meal timing with chronotype is associated with 38% lower odds of prediabetes or type 2 diabetes.
No significant associations were found for weekend alignment with glycaemic parameters.
No significant interactions were observed between the alignment of activity and meal timing.
Findings suggest that the timing of daily behaviours in relation to chronotype may influence metabolic health.

AI simplified

AIMS: Little is known about how the alignment between daily behaviours, such as physical activity and eating, and relates to glucose metabolism. We investigated whether alignment of physical activity and meal timing with chronotype was associated with glycaemic parameters and with prediabetes or type 2 diabetes (T2DM).

MATERIALS AND METHODS: In a cross-sectional analysis of 1384 participants from The Maastricht Study, we examined associations between behaviour-chronotype alignment and glucose metabolism. Physical activity timing was assessed by accelerometry and defined as the daypart with the highest step count. Meal timing, from a chrono-nutrition questionnaire, was defined as the daypart with the most eating occasions. Chronotype was estimated using the midpoint of sleep on free days corrected for sleep debt. Alignment reflected concordance between behaviour timing and chronotype. Confounder-adjusted logistic and linear regression models estimated associations with (pre)diabetes and with log-transformed fasting plasma glucose (FPG), 2-h post-load glucose (2hPLG), and haemoglobin A1c ().

RESULTS: Weekday alignment of physical activity timing with chronotype was associated with lower HbA1c (β per 20% more aligned weekdays: -0.48%, 95% CI -0.95, -0.02). Weekday meal timing alignment was associated with lower odds of prediabetes or T2DM (OR aligned vs. misaligned: 0.62, 95% CI 0.43-0.89). No significant associations were observed for weekend alignment, for FPG or 2hPLG, or for interactions between activity and meal timing alignment.

CONCLUSIONS: Weekday, but not weekend, alignment of physical activity and meal timing with chronotype was modestly associated with more favourable glucose metabolism. These findings suggest a potential role of behaviour-chronotype alignment in metabolic health, warranting confirmation in prospective and intervention studies.

Key numbers

-0.48%

Decrease in

Per 20% more aligned weekdays.

0.62

Lower odds of prediabetes or T2DM

Aligned vs. misaligned participants.

Full Text

We can’t show the full text here under this license. Use the link below to read it at the source.

View full text (PDF) ↗View full text (XML) ↗View full text ↗

Featured in

Circadian BiologyIssue #23

Morning-loaded eating suppresses ghrelin more than evening meals — and artificial light disrupts immune rhythms in wild rodents

↗

Physical activity and meal timing alignment with chronotype and their associations with glucose metabolism: The Maastricht Study

Abstract

Key numbers

Full Text

Featured in

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Key numbers

Full Text

Related papers

Featured in

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief