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Sleep and Circadian Hygiene and Inflammatory Bowel Disease
Sleep and Daily Rhythm Habits in Inflammatory Bowel Disease
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Abstract
Sleep and circadian disruption is associated with worse outcomes in inflammatory bowel disease (IBD).
- Sleep and circadian disruption may worsen the disease course in IBD.
- These disruptions are prevalent in society and could be linked to disease flares.
- Key components affected by sleep disruption in IBD may include intestinal permeability, bacterial endotoxin translocation, intestinal dysbiosis, and proinflammatory cytokines.
- Much of the current research on this topic has been conducted in animal models.
- There is a need for large randomized controlled trials to explore chronotherapeutic strategies in human IBD patients.
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