Sleep and Daily Rhythm Habits in Inflammatory Bowel Disease

Sleep and circadian disruption is associated with worse outcomes in inflammatory bowel disease (IBD).

• Sleep and circadian disruption may worsen the disease course in IBD.
• These disruptions are prevalent in society and could be linked to disease flares.
• Key components affected by sleep disruption in IBD may include intestinal permeability, bacterial endotoxin translocation, intestinal dysbiosis, and proinflammatory cytokines.
• Much of the current research on this topic has been conducted in animal models.
• There is a need for large randomized controlled trials to explore chronotherapeutic strategies in human IBD patients.

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