Regulation of vitellogenin gene expression under the negative modulator, gonad-inhibiting hormone in Penaeus monodon

Feb 25, 2020Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

How gonad-inhibiting hormone controls egg yolk protein gene activity in Penaeus monodon

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Abstract

A total of 102 up-regulated and 82 down-regulated genes were identified in GIH-knockdown shrimp.

  • Gonad-inhibiting hormone (GIH) negatively regulates vitellogenin (Vg) synthesis during ovarian maturation in crustaceans.
  • Calreticulin (CALR) expression is significantly reduced in vitellogenic ovaries, indicating a potential role in vitellogenesis.
  • Suppression of CALR using specific dsRNA results in elevated Vg transcript levels in the ovary.
  • CALR may inhibit vitellogenin synthesis by binding to steroid hormone receptors, affecting gene expression.
  • Findings suggest a novel pathway of GIH signaling that may disrupt the steroid signaling cascade to regulate Vg synthesis.

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