Trending CRISPR Gene Editing Research Papers

yesterday • The Journal of clinical investigation

A single muscle-targeting gene therapy that avoids the liver improves muscular dystrophy in human-like mice using precise gene editingA single liver-sparing myotropic AAV ameliorates muscular dystrophy in humanized mice by base editing.

🥈 Top 2% JournalFulltext (Open License)Article

yesterday • Journal of hepatology

Liver biopsy shows accurate and effective correction of SERPINA1 gene by base editing in a patient with Alpha-1 Antitrypsin DeficiencyLiver biopsy confirms precise and efficient correction of SERPINA1 after in vivo Base Editing in a Patient with Alpha-1 Antitrypsin Deficiency.

🥇 Top 1% JournalCase Reports

1 week ago • Viruses

Combined Analysis of Genetic Screens to Find Human Factors Involved in HIV-1 InfectionSystematic Review and Meta-Analysis of Genome-Wide CRISPR-Cas Screens to Identify Host Factors Involved in HIV-1 Infection.

📖 Top 20% JournalSystematic Review

yesterday • STAR protocols

Method for detailed genetic analysis of editing results from nuclease, base, and prime techniques using CleanFinderProtocol for comprehensive genotyping of nuclease, base, and prime editing outcomes using CleanFinder.

📖 Top 20% JournalArticle

5 days ago • STAR protocols

Method for precise large DNA segment editing to create identical human stem cells using CRISPR-Cas9Protocol for precise large-region haplotype modification for isogenic human iPSC generation using CRISPR-Cas9.

📖 Top 20% JournalArticle

4 days ago • Nature communications

Using Cas12a2’s self-destruct response for efficient and low-toxicity microbial genome editingRepurposing Cas12a2-mediated abortive infection for efficient and low-toxicity microbial genome editing.

🥈 Top 2% JournalArticle

4 days ago • Nature communications

Changes in 3D DNA contacts predict shifts in gene regulation when cohesin is reducedQuantitative changes in 3D contact predict changes in enhancer-promoter regulation upon cohesin depletion.

🥈 Top 2% JournalArticle

4 days ago • Molecular genetics and genomics : MGG

Advances in fixing genetic diseases by prime editing inside the bodyResearch progress of gene correction for genetic diseases via in vivo prime editing.

📖 Top 50% JournalArticle

1 week ago • Biomedicines

Gene Editing for Breathing Diseases: From Lab Models to Possible TreatmentsGene-Editing in Respiratory Disease: From Pre-Clinical Human Models to Future Therapeutics.

📖 Top 20% JournalArticle

1 week ago • Genes

High-Precision Virus-Like Particles Carrying Cas12m for Changing DNA Bases from A to G and C to TEngineering of the High-Precision Cas12m Dual Base Editor-Loaded Virus-like Particles for A-to-G and C-to-T Conversions.

📖 Top 20% JournalArticle

3 days ago • Biomaterials

Using targeted nanoparticles to deliver precise DNA editing for lung cancer treatmentTranscription activator-like effector base editing delivered by a targeted lipid nanoparticle for therapy of lung cancer.

🥉 Top 5% JournalArticle

5 days ago • Frontiers in genome editing

Using CRISPR to improve sugar crops' resistance to environmental stressesCRISPR/Cas genome editing strategies to enhance abiotic stress tolerance in sugar crops.

🎖️ Top 10% JournalArticle

1 week ago • Angewandte Chemie (International ed. in English)

Comparing Two Polymers for Making Lipid Nanoparticles Without Organic SolventsComparative Analysis of Poly(Ethylene Glycol) (PEG) and Poly(2-Ethyl-2-Oxazoline) (PEtOx) for Organic Solvent-Free Lipid Nanoparticle Formulations.

🥇 Top 1% JournalArticle

yesterday • Journal of genetics and genomics = Yi chuan xue bao

Triggering death receptor 5 makes cancer cells more vulnerable to attack by natural killer and T cellsActivating death receptor 5 exposes a cancer cell vulnerability to natural killer and T cell attack.

🎖️ Top 10% JournalArticle

5 days ago • Nature plants

SmartPE allows precise gene editing in dicot crop plantsSmartPE enables efficient prime editing in dicot crops.

🥇 Top 1% JournalArticle

1 week ago • Plants (Basel, Switzerland)

Gene Editing of Grapevine MLO Genes Linked to Powdery Mildew Resistance and Plant GrowthCRISPR-Cas9 Editing of Grapevine Clade V-Related MLO Genes: Grapevine Powdery Mildew Resistance (Erysiphe necator) and Plant Development Effects.

📖 Top 20% JournalArticle

1 week ago • International journal of molecular sciences

Functional Groups Linked to Olaparib Resistance Beyond DNA Repair Identified by CRISPR ScreensBeyond Homologous Recombination: Functional Modules of Olaparib Resistance Revealed by CRISPR Screens.

📖 Top 20% JournalArticle

4 days ago • Cell death and differentiation

DCST1 may cause cisplatin resistance in bladder cancer by stabilizing NFAT5 and blocking cell deathDCST1 drives cisplatin resistance via non-canonical ubiquitination and stabilization of NFAT5 to suppress PANoptosis in bladder cancer.

🥇 Top 1% JournalArticle

6 days ago • The Journal of experimental medicine

Cbfβ controls DNA folding to regulate different Il4 and Il13 gene activity in Th2 immune cellsCbfβ regulates DNA looping at the Il4-Il13 loci to control their differential expression in Th2 cells.

🥇 Top 1% JournalArticle

5 days ago • Nature biotechnology

A smaller engineered Cas12m protein for activating multiple genes at once in living organismsAn engineered, compact Cas12m variant for multiplexed gene activation in vivo.

🏆 Top 0.1% JournalArticle

1 week ago • NAR cancer

xNNPCD finds key controllers of programmed cell death by combining gene changes after treatment with cancer cell survival dataxNNPCD identifies regulators of programmed cell death by integrating perturbation transcriptomes with cancer dependency profiles.

🎖️ Top 10% JournalArticle

2 days ago • Talanta

Using a special protein and Cas12a to detect tetracycline with high sensitivityTranscription factor-regulated rolling circle transcription cascaded with Cas12a for sensitive determination of tetracycline.

📖 Top 20% JournalArticle

5 days ago • Nature structural & molecular biology

How the R2 Retrotransposon Works with CRISPR-Cas9 to Insert Genes in Specific PlacesStructural mechanism of programmable gene integration by the R2 retrotransposon coupled with CRISPR-Cas9.

🥇 Top 1% JournalArticle

1 week ago • Molecular therapy. Oncology

Gene Therapy as a New Cellular Approach to Treat CancerGene therapy as an upcoming technique in the treatment of cancer: A cellular solution to a cellular problem.

🎖️ Top 10% JournalArticle

5 days ago • Methods in molecular biology (Clifton, N.J.)

Light-Controlled Method to Regulate the p53 Cell Stress PathwayOptogenetic Tool for Controlling p53 Signaling Pathway.

📖 Top 50% JournalArticle