Trending CRISPR Gene Editing Research Papers

3 days ago • Applied microbiology and biotechnology

A single-plasmid CRISPR-Cas9 system for genome editing in Bacillus bacteria that works without added inducersAn inducer-independent, single-plasmid CRISPR-Cas9 system for genome editing in Bacillus species.

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4 days ago • Biology

Goals, Public Views, and Uses of Genetically Modified and Gene-Edited OrganismsGenetically Modified and Gene-Edited Organisms-Objectives, Public Perception and Applications.

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4 days ago • Plants (Basel, Switzerland)

Using CRISPR Gene Editing to Improve Solanaceae CropsGenome Editing in Solanaceae: Harnessing CRISPR-Cas Technology for Precision Crop Improvement.

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3 days ago • Hepatology communications

Editing the MTARC1 A165T gene variant in human liver models shows lower fat buildup, inflammation, and scarringPrime editing models the MTARC1 A165T variant in human liver organoids, demonstrating reduced steatosis, inflammation, and fibrosis.

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3 days ago • Molecular genetics and genomics : MGG

How Advances in Accuracy Are Changing Therapeutic Genome EditingFrom scissors to editors: how the evolution of precision is redefining therapeutic genome editing.

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4 days ago • Trends in biotechnology

Targeting CRISPR-Cas9 with sugar-tagged DNA pieces for selective and broad inhibitionCross-target and cell-preferential CRISPR-Cas9 inhibition with carbohydrate-tagged oligonucleotides.

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4 days ago • Cells

Loss of VPS13B protein in cells causes stress in cell compartments, slower cell division, and formation of fibrous clumps linked to Cohen SyndromeModeling Cohen Syndrome in Phoenix Cells: VPS13B Loss Causes Organelle Stress, G1/S Delay, and Fibrillary Inclusion Bodies Formation.

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3 days ago • Human gene therapy

Creating a Gene Editor Delivered by Virus to Treat Duchenne Muscular DystrophyDevelopment of an AAV-Encoded Adenine Base Editor for Duchenne Muscular Dystrophy.

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3 days ago • Journal of visualized experiments : JoVE

Creating Genetically Modified Sheep Embryos Using Gene Editing and Cell Transfer to Model Human DiseasesGeneration of Genetically Engineered Embryos Using Gene Editing and Somatic Cell Nuclear Transfer for Production of Sheep Models of Human Disease.

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3 days ago • Metabolic brain disease

Using gene editing in lab-grown human nerve cells to study autismCRISPR-Enabled functional genomics in hPSCs-derived neural models for autism spectrum disorder.

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3 days ago • STAR protocols

Method for strong gene removal and accurate testing in human cells using four-guide RNA vectorsProtocol for robust gene knockout and reliable validation in human cell lines using quad-guide RNA vectors.

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3 days ago • The Journal of biological chemistry

Key arginine residues in Cas12a differently influence DNA cutting and accuracyActive-site arginines differentially control Cas12a DNA cleavage and specificity.

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5 days ago • Trends in plant science

Prime editing improves precise plant breeding from testing to reliable resultsFrom feasibility to predictability: prime editing redefines precision breeding in plants.

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5 days ago • iScience

Improving precise gene editing by blocking DNA repair in a spider relativeInterfering with DNA repair pathways to enhance CRISPR-Cas9-mediated homology-directed repair in a chelicerate genetic model.

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4 days ago • Current gene therapy

Progress and Challenges in Using Adenine Base Editors for Biology and MedicineAdvances in the Application of Adenine Base Editor (ABE) in Biology and Medicine: Prospects and Challenges.

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3 days ago • NAR genomics and bioinformatics

Using CRISPR-Cas9 and long-read sequencing to enrich and study rare host and viral RNA typesCustomizable host and viral transcript enrichment using CRISPR-Cas9 long-read sequencing for characterization of low-to-moderate abundance isoforms.

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3 days ago • Stem cell research

Using gene editing to fix a KRT5 mutation in patient-derived stem cells from severe epidermolysis bullosa simplexHomology-directed CRISPR-Cas9 correction of the KRT5 p.E475G mutation in human iPSC line from a patient with severe epidermolysis bullosa simplex.

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1 week ago • Nature biomedical engineering

Changes to RNA patterns improve prime editing in living cells and boost different editing methodsDense RNA motif modifications enable robust in vivo prime editing and enhance efficiencies of diverse editing systems.

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3 days ago • Journal, genetic engineering & biotechnology

How mRNA-Lipid Nanoparticles Help Gene Editing and Affect Immune ResponsesAdvancements of mRNA-lipid nanoparticle links to gene editing and immune responses.

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3 days ago • Current microbiology

Using Plant Viruses as Tools for Advanced FarmingTransforming Plant Viruses into Vectors for Next-Generation Agriculture-A Review.

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6 days ago • Bioresource technology

High-yield production of 1,3-propanediol by genetically edited Klebsiella pneumoniae using glycerol and plant-based sugarsHighly efficient production of 1,3-propanediol by CRISPR-Cas12a-edited Klebsiella pneumoniae using glycerol and lignocellulosic hydrolysate as co-substrates.

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1 week ago • FEBS open bio

Removing IGF2 lowers but does not stop bone cancer growth in lab dishes and living modelsIGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo.

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3 days ago • Science translational medicine

A fast CRISPR nanodroplet test for directly identifying mycobacteria species in clinical samplesA rapid CRISPR-based nanodroplet assay enables direct clinical identification of mycobacteria species.

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5 days ago • Journal of photochemistry and photobiology. B, Biology

Light-controlled gene-editing nanoparticles to manage kidney scarringLight-activated CRISPR/dCas9 nanomedicine for programmable control of renal fibrosis.

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3 days ago • Stem cell research

Labeling the TBXT gene with a glowing marker in human embryonic stem cells using CRISPR gene editingEndogenous tagging of the TBXT (Brachyury) gene with 2A-EGFP in BJNhem19 human embryonic stem cells using CRISPR-Cas9 genome editing.

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2 days ago • Journal of microbiological methods

Checking hidden gene tests for overlapping gene errors: a detailed study of Rv2438A in tuberculosis bacteriaAuditing bacterial dark-gene screens for superimposed open reading frame artefacts: A multi-layer analysis of Rv2438A in Mycobacterium tuberculosis.

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1 week ago • Journal of visualized experiments : JoVE

Using Genetic Deletion of Gene Control Regions to Study Non-Coding DNA Function in Early Human Development ModelsGenetic Deletion of Cis-Regulatory Elements to Dissect the Function of the Non-coding Genome in human Preimplantation Models.

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3 days ago • Nature microbiology

A chemical change to DNA-packaging proteins helps malaria parasites decide to become male or femaleHistone H2B monoubiquitination drives sexual commitment in malaria parasites.

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4 days ago • International journal of molecular sciences

Using CRISPR to Create Melanoma Stem Cells That Are Vulnerable Without CD133Correction: Simbulan-Rosenthal et al. Employing CRISPR-Cas9 to Generate CD133 Synthetic Lethal Melanoma Stem Cells. Int. J. Mol. Sci. 2022, 23, 2333.

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4 days ago • Biology

Using Fruit Fly Models to Find Natural Medicines: Shared Disease Signaling Paths and a Flexible Testing MethodDrosophila melanogaster Models for Natural Product Discovery: Cross-Disease Conserved Signaling Networks and a Generalizable Translational Pipeline.

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