CRISPR Gene Editing Research Papers

2 weeks ago • International journal of molecular sciences

Comparing Prime Editing and CRISPR Methods to Fix the CFTR-F508del Mutation in Patient-Derived Airway Stem CellsComparison of Prime Editing and CRISPR-Cas Mediated HDR in Correcting CFTR-F508del Mutation in Patient iPSC-Derived Airway Basal Cells.

📖 Top 20% JournalComparative Study

1 week ago • Viruses

Combined Analysis of Genetic Screens to Find Human Factors Involved in HIV-1 InfectionSystematic Review and Meta-Analysis of Genome-Wide CRISPR-Cas Screens to Identify Host Factors Involved in HIV-1 Infection.

📖 Top 20% JournalSystematic Review

3 weeks ago • Med (New York, N.Y.)

Gene editing for inherited angioedema: a major trial and remaining questionsGenome editing for hereditary angioedema: A landmark trial and important unanswered questions.

🥈 Top 2% JournalArticle

2 weeks ago • Plant cell reports

Restoring function to a broken SlGLK2 gene in tomato using precise genome editingReactivation of a loss-of-function SlGLK2 allele by frame-restoring genome editing in tomato.

🎖️ Top 10% JournalArticle

3 weeks ago • Frontiers in genome editing

Genome-edited sheep created by delivering prime editing proteins into fertilized eggs using electric pulsesGenome edited sheep generated by zygote electroporation of prime editor ribonucleoproteins.

🎖️ Top 10% JournalArticle

3 weeks ago • Nature communications

Gene editing reveals two roles of DNMT3A in helping tumors avoid the immune systemIn vivo CRISPR screens identify dual functions of DNMT3A in mediating tumor immune evasion.

🥈 Top 2% JournalResearch Support, Non-U.S. Gov't

yesterday • The Journal of clinical investigation

A single muscle-targeting gene therapy that avoids the liver improves muscular dystrophy in human-like mice using precise gene editingA single liver-sparing myotropic AAV ameliorates muscular dystrophy in humanized mice by base editing.

🥈 Top 2% JournalFulltext (Open License)Article

2 weeks ago • Nature communications

cPRIME allows natural mapping of genetic variant effects on RNAcPRIME enables endogenous mapping of genetic variant effects at RNA level.

🥈 Top 2% JournalResearch Support, Non-U.S. Gov't

3 weeks ago • Nature communications

How Cattle Establish Pregnancy Without Embryo Signaling Protein Interferon TauPregnancy establishment in cattle without embryonic interferon tau.

🥈 Top 2% JournalResearch Support, Non-U.S. Gov't

2 weeks ago • ACS applied materials & interfaces

Testing many lipid nanoparticles to find the best ones for delivering CRISPR gene-editing toolsHigh-Throughput Screening of a Lipid Nanoparticle (LNP) Library Identifies Lead Formulations for CRISPR-Cas9 Ribonucleoprotein Delivery and Gene Editing.

🎖️ Top 10% JournalArticle

2 weeks ago • Current atherosclerosis reports

Single-dose gene-editing therapies targeting PCSK9 in living organismsIn-vivo CRISPR/Base-Editing "One-Shot" Therapies Targeting PCSK9.

🎖️ Top 10% JournalArticle

2 weeks ago • Biosensors & bioelectronics

RNA-controlled CRISPR test for detecting tuberculosis and rifampicin drug resistance at the same timeUnified hybrid RNA-regulated CRISPR diagnostic for concurrent Mycobacterium tuberculosis detection and rifampicin resistance profiling.

🥉 Top 5% JournalArticle

4 weeks ago • Cell

Glutathione's unexpected role in preventing cell damage by ferroptosis through FSP1A non-canonical function of glutathione to suppress ferroptosis via FSP1.

🏆 Top 0.1% JournalArticle

4 days ago • Nature communications

Changes in 3D DNA contacts predict shifts in gene regulation when cohesin is reducedQuantitative changes in 3D contact predict changes in enhancer-promoter regulation upon cohesin depletion.

🥈 Top 2% JournalArticle

5 days ago • Frontiers in genome editing

Using CRISPR to improve sugar crops' resistance to environmental stressesCRISPR/Cas genome editing strategies to enhance abiotic stress tolerance in sugar crops.

🎖️ Top 10% JournalArticle

1 week ago • Angewandte Chemie (International ed. in English)

Comparing Two Polymers for Making Lipid Nanoparticles Without Organic SolventsComparative Analysis of Poly(Ethylene Glycol) (PEG) and Poly(2-Ethyl-2-Oxazoline) (PEtOx) for Organic Solvent-Free Lipid Nanoparticle Formulations.

🥇 Top 1% JournalArticle

1 week ago • Plants (Basel, Switzerland)

Gene Editing of Grapevine MLO Genes Linked to Powdery Mildew Resistance and Plant GrowthCRISPR-Cas9 Editing of Grapevine Clade V-Related MLO Genes: Grapevine Powdery Mildew Resistance (Erysiphe necator) and Plant Development Effects.

📖 Top 20% JournalArticle

1 week ago • International journal of molecular sciences

Functional Groups Linked to Olaparib Resistance Beyond DNA Repair Identified by CRISPR ScreensBeyond Homologous Recombination: Functional Modules of Olaparib Resistance Revealed by CRISPR Screens.

📖 Top 20% JournalArticle

1 week ago • Biomedicines

Gene Editing for Breathing Diseases: From Lab Models to Possible TreatmentsGene-Editing in Respiratory Disease: From Pre-Clinical Human Models to Future Therapeutics.

📖 Top 20% JournalArticle

1 week ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Phosphate-Modified DNA Improves CRISPR-Cas12a's Ability to Quickly and Accurately Detect Genetic MaterialPhosphate-Engineered DNA Reporters Boost CRISPR-Cas12a Trans-Cleavage for Rapid and Sensitive Nucleic Acid Detection.

🥈 Top 2% JournalArticle

1 week ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Using CRISPR in living models to identify RPS19 as a target for immunotherapy in liver cancerIn Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma.

🥈 Top 2% JournalArticle

1 week ago • Biosensors

A CRISPR-Cas12a Biosensor System for Testing the Effects of Pesticide ResiduesA Collective CRISPR-Cas12a Biosensing Platform for Effect-Based Screening of Pesticide Residues.

📖 Top 20% JournalArticle

1 week ago • Cells

How Artificial Intelligence May Help Improve Cell Therapies for Eye DiseasesArtificial Intelligence as a Catalyst for Cell-Based Therapies in Retinal Disease.

🎖️ Top 10% JournalArticle

1 week ago • Journal of fungi (Basel, Switzerland)

Fast Visual Test Combining DNA Amplification and CRISPR to Detect Pear Canker PathogensRapid Visual LAMP-CRISPR/Cas12a Detection System for Cytospora Pathogens Associated with Pear Canker Integrating Isothermal Amplification with Programmable Secondary Recognition.

📖 Top 20% JournalArticle

1 week ago • Frontiers in cellular neuroscience

Cell and gene activity changes from activating dopamine-making enzymes in cell models of Parkinson’s damageAssessment of the transcriptional and cellular effects of CRISPRa targeting Dopa decarboxylase and GTP cyclohydrolase 1 in HEK293 and SH-SY5Y cellular models of Parkinsonian neurotoxicity.

🎖️ Top 10% JournalArticle

1 week ago • Microbiology spectrum

Development and initial use of a fast CRISPR-based test methodEstablishment and preliminary application of the Mo RPA-CRISPR/Cas12a rapid detection method.

📖 Top 20% JournalArticle

1 week ago • Bioresources and bioprocessing

Using targeted gene editing to disable a specific part of glutamine synthetase creates high-producing CHO cells for making antibodiesBase editing-mediated exon-specific knockout of glutamine synthetase generates a high-productivity CHO cell line for antibody manufacturing.

📖 Top 20% JournalArticle

1 week ago • Frontiers in pharmacology

Quercetin increases TLE4 to block a cell growth pathway and reduce cervical cancer cell movement and spreadQuercetin upregulates TLE4 to block the Wnt/β-catenin signaling pathway and inhibit cell migration and invasion of cervical cancer cells.

📖 Top 20% JournalArticle

1 week ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Redesigning RNA Structures to Reduce Leakage in CRISPR/Cas12a Systems for More Accurate Genetic TestingScaffold RNA Reengineering for a Leakage-Suppressed CRISPR/Cas12a Cascade System Toward Precise Nucleic Acid Diagnostics.

🥈 Top 2% JournalArticle

2 weeks ago • eLife

Using CRISPRi to reveal a gene activity switch between KLF activators and repressors in the developing thinking areas of the brainMultiplexed CRISPRi reveals a transcriptional switch between KLF activators and repressors in the maturing neocortex.

🥈 Top 2% JournalArticle

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