During an average follow-up of 10.9 years, 7468 (2.8%) cases of (AMD) were documented.
Individuals with moderate (CVH) had a 14% reduced risk of developing AMD compared to those with low CVH.
Those with high CVH levels experienced a 23% reduction in AMD risk.
A linear dose-response relationship exists between the cumulative Life's Essential 8 (LE8) score and AMD incidence.
Achieving optimal CVH could potentially prevent 9.4% of AMD cases.
Ideal blood glucose and blood pressure levels are associated with reductions of 3.3% and 8.7% in AMD cases, respectively.
Simplified
PURPOSE: This study aimed to investigate the correlation between (CVH), evaluated through the Life's Essential 8 (LE8) score, and the risk of new-onset (AMD).
METHODS: This longitudinal analysis included 271,274 participants who were free of both cardiovascular diseases and AMD at baseline. The LE8 score was classified into three categories: low (<50 points), moderate (50 to <80 points), and high (≥80 points), with higher scores indicating better CVH. Cox proportional hazards models were used to explore the relationships between the CVH and AMD incidence. Furthermore, the population attributable risk (PAR%) was calculated for CVH and each individual metric.
RESULTS: During an average follow-up duration of 10.9 years, a total of 7468 (2.8%) cases of AMD were documented. Individuals with moderate and high CVH levels had a 14% (hazard ratio [HR] = 0.86; 95% confidence interval [CI], 0.78-0.94) and 23% (HR = 0.77; 95% CI, 0.69-0.86) reduced risk of developing AMD, respectively. A linear dose-response relationship was identified between the cumulative LE8 score and the incidence of AMD. Attaining optimal CVH in all individuals could potentially avert 9.4% (95% CI, 3.7%-15.1%) of AMD cases. Among the CVH metrics, ideal blood glucose and blood pressure levels were related to a reduction of 3.3% and 8.7% in AMD cases, respectively.
CONCLUSIONS: Enhanced CVH is significantly associated with a reduced risk of developing AMD. Promoting CVH through the LE8 guideline might potentially contribute to the prevention of AMD.
Key numbers
14%
Decrease in Risk with Moderate
Hazard ratio for moderate vs. low
23%
Decrease in Risk with High
Hazard ratio for high vs. low
9.4%
Potential Cases Prevented by Optimal
Population attributable risk percentage for achieving high
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Disclosure: Y. Peng , None; Y. Zhang , None; K.W. Kam , None; G. Wong , None; M. Ho , None; S. Szeto , None; S. Au , None; X. Zhang , None; M.P.H. Ng , None; P. Ip , None; A. Young , None; C.P. Pang , None; C.C. Tham , None; L.J. Chen , None; J.C. Yam , None
