What is the nature of sleep and circadian rhythm health on gastrointestinal microbiota? A systematic review of studies in humans

Findings from 41 studies suggest that sleep disturbances may be linked to gut microbiome composition and function.

• Sleep truncation, disturbances, and circadian misalignment could be associated with changes in gut microbiome composition.
• The microbial families Oscillospiraceae and Ruminococcaceae are often linked to sleep and circadian health metrics.
• Functional outputs of the gut microbiome, when assessed, indicated roles in various metabolic pathways, including amino acids and fatty acids.
• Mixed results regarding microbial diversity may be due to variations in study design, participant demographics, and lifestyle factors.
• Future research should focus on longitudinal and experimental studies to better understand causal relationships and potential interventions.

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