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3 days ago • Experimental gerontology

Brain aging clocks: New methods and underlying cell processesBrain aging clocks: From methodological advances to cellular mechanisms.

Article

4 days ago • Journal of pharmaceutical analysis

Flavonoids from Shenrong Guben Huanshao Pill may improve age-related mitochondrial problems by changing metabolism through NDUFV2 and LDHBFlavonoid compounds from Shenrong Guben Huanshao Pill alleviates senescence-associated mitochondrial dysfunction through NDUFV2 and LDHB mediated metabolic reprogramming.

Article

4 days ago • Brain : a journal of neurology

Widespread problems with energy production in muscle cells in inclusion body myositisMultilevel impairment of mitochondrial respiration in inclusion body myositis.

Article

4 days ago • Genetics

Protein helpers linked to ribosomes coordinate mitochondrial protein import, stress signals, and protein balance in yeastRibosome-associated chaperones integrate co-translational mitochondrial protein import, stress signaling and proteostasis in Saccharomyces cerevisiae.

Article

5 days ago • Rejuvenation research

Biological Age: A New Idea or Just Different Words?Biological Age: A New Concept or a Linguistic Pivot?

Article

5 days ago • International journal of molecular medicine

Brazilin reduces blood vessel cell damage caused by methylglyoxal by boosting a protein modification and blocking a cell recycling and death pathway in lab and animal studiesBrazilin attenuates methylglyoxal‑induced endothelial injury by enhancing eIF5A hypusination and inhibiting the AMPK/mTOR‑mediated autophagy/apoptosis axis in vitro and in vivo.

Article

5 days ago • The Plant journal : for cell and molecular biology

COG7 connects Golgi structure to stress response and cell agingCOG7 links Golgi integrity to stress signaling and senescence.

Article

5 days ago • Experimental gerontology

Using n-acetylcysteine to reduce cell aging in human blood vessel cells through the HuR pathwayFrom antioxidant to senotherapeutic: Repurposing n-acetylcysteine to counteract senescence via the HuR pathway in human endothelial cells.

Article

6 days ago • Brain, behavior, and immunity

EPA may help balance brain immune function in schizophrenia through cell cleanup processesEPA restores neuroimmune homeostasis in Schizophrenia: evidence for the involvement of autophagy.

Article

6 days ago • American journal of physiology. Renal physiology

Too much protein taken up by kidney receptors leads to increased cell growth and aging in kidney tubules of protein-leaking mice, mainly in the outer kidney regionExcessive protein uptake by endocytic receptors causes elevated proliferation and senescence in proximal tubules primarily in outer medulla of proteinuric mice.

Article

1 week ago • Nature cell biology

The enzyme PGAM1 controls cell metabolism and recycling to balance growth and stress survivalThe glycolytic enzyme PGAM1 functions as a metabolic-autophagy checkpoint to coordinate growth and stress tolerance.

Article

1 week ago • The Journal of cell biology

Overactive PARP1 slows protein production and causes stress granules after DNA damagePARP1 hyperactivity stalls translation and triggers stress granule formation following DNA damage.

Article

1 week ago • Proceedings of the National Academy of Sciences of the United States of America

Timing and location of Atg2 joining the cell's membrane system during autophagosome formationSpatiotemporal control of Atg2 association with the ER during autophagosome formation.

Article

1 week ago • International immunopharmacology

Dehydrodiisoeugenol may improve ulcerative colitis by reducing cell aging through AKT inhibition and GSK3B activationDehydrodiisoeugenol ameliorates DSS-induced ulcerative colitis by suppression of cellular senescence through inhibiting AKT and activating GSK3B.

Article

1 week ago • The Journal of pharmacology and experimental therapeutics

Changes in Alzheimer's disease linked to M1 muscarinic receptor activity differ between male and female APPswe/PSEN1ΔE9 miceM1 muscarinic receptor modulation drives sex-specific alterations of Alzheimer's pathophysiology in APPswe/PSEN1ΔE9 mice.

Article

1 week ago • Nature cell biology

A key cell enzyme helps change gene packaging during fastingNuclear class 3 PI3K co-activates fasting-specific chromatin remodelling.

Article

1 week ago • Biochimica et biophysica acta. Molecular basis of disease

Pannexin1 may promote cell aging by causing mitochondrial DNA release that triggers an immune sensing pathwayPannexin1 promotes cellular senescence by triggering mtDNA release to activate the cGAS-STING pathway.

Article

1 week ago • Mechanisms of ageing and development

Improving the Anti-Aging Effects of Human Umbilical Cord Stem Cells with NMN in Aging Mouse and Cell ModelsEnhancing the Anti-Aging Capacity of hUC-MSCs via NMN Co-Treatment in D-Galactose-Induced Mice and Cellular Senescence Models.

Article

1 week ago • Cardiovascular drugs and therapy

Cell Aging in Diabetes-Related Heart Disease: How It Happens and Possible TreatmentsCellular Senescence in Diabetic Cardiomyopathy: Mechanistic Insights and Therapeutic Perspectives.

Article

1 week ago • Experimental gerontology

Muscle Signals Connecting Muscle Loss to Thinking Decline and Possible Prevention in AgeingMyokines as molecular mediators of the muscle-brain axis: Mechanisms linking sarcopenia to cognitive decline and implications for preventive strategies in ageing - A narrative review.

Article

1 week ago • Progress in neuro-psychopharmacology & biological psychiatry

Targeting specific HSP90 protein types as a precise treatment approach for brain and metabolic diseasesIsoform-selective HSP90 inhibition as a precision therapeutic strategy for neurodegenerative and metabolic diseases.

Article

1 week ago • Cureus

Genes Involved in Cell Recycling May Be Linked to Obsessive-Compulsive Disorder Through Energy-Related Cell MaintenanceAutophagy-Related Gene-Set Signals in the Genetic Architecture of Obsessive-Compulsive Disorder: A Hypothesis-Generating Link to Nicotinamide Adenine Dinucleotide-Associated Cellular Maintenance Biology.

1 week ago • Journal of dental research

A Dual-Function Barrier Membrane May Improve Bone Healing in Older AdultsA Bioactive Janus Barrier Membrane Rejuvenates Bone Regeneration in Aging.

1 week ago • Experimental gerontology

Drugs targeting multiple pathways to reduce harmful cell aging signals for healthier agingSenomorphic agents: Multi-target strategies to tame the senescence-associated secretory phenotype for healthy ageing.

1 week ago • Behavioural brain research

Lidocaine may reduce postoperative delirium by triggering removal of damaged mitochondria to lower harmful molecules and prevent inflammatory microgliaActivation of Mitophagy by Lidocaine Limits mROS and Prevents Microglial M1 Polarization to Alleviate Postoperative Delirium.

1 week ago • Pathology, research and practice

Precision approaches to control T cell activation, movement, and self-cleaning by targeting the CD31 immune-metabolism pathwayTargeting the CD31 immunometabolic axis: Precision strategies for modulating T cell activation, migration, and autophagy.

1 week ago • International immunopharmacology

Luteolin may reduce cell aging and inflammation caused by cigarette smoke in mice through a specific cell protection pathwayLuteolin is associated with alleviation of cigarette smoke-induced cellular senescence and inflammation in mice involving the CREB/c-Fos/NQO1 pathway.

1 week ago • Experimental cell research

Bone marrow stem cell exosomes may reduce bone loss by blocking bone-breakdown cells through RBM15B/YAP1-triggered cell recyclingExosomes from bone marrow mesenchymal stem cells inhibit osteoclast differentiation and alleviate osteoporosis via RBM15B/YAP1 to induce autophagy.

2 weeks ago • Behavioural brain research

Electroacupuncture may reduce memory problems from heart-lung bypass by helping cell cleanup and brain connection repairElectroacupuncture mitigates cognitive impairment caused by CPB by facilitating PINK1-dependent mitophagy and synaptic plasticity.

2 weeks ago • Biochimica et biophysica acta. Molecular cell research

Lack of RSL1D1 weakens iron storage and triggers cell death and aging in eye support cells in diabetic retinopathyRSL1D1 deficiency reduces FTH1 stability and induces ferroptosis and senescence in retinal pigment epithelial cells in diabetic retinopathy.

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Longevity & Aging Research Papers