Latest Longevity & Aging Research Papers

yesterday • Tissue & cell

How different cell death and cleanup processes interact in sudden pancreas inflammation and what this means for treatmentInterplay between mitophagy, ferroptosis, and pyroptosis in acute pancreatitis: Regulatory mechanisms and therapeutic implications.

📖 Top 30% JournalArticle

yesterday • Journal of drug targeting

Aging Skin Cells Release Particles That Affect Skin Aging and Repair, Offering Potential Treatment OptionsSenescence-Associated Extracellular Vesicles in Skin Aging and Regeneration: From Pathophysiology to Therapeutic Opportunities.

📖 Top 20% JournalArticle

yesterday • Journal of molecular medicine (Berlin, Germany)

How early cell aging, inflammation, and cell energy communication relate to CBD’s heart-protective effects in heart failure with preserved pumping functionProspective associations of premature senescence, inflammation, and MERCSs in the cardioprotective effect of CBD in HFpEF.

🎖️ Top 10% JournalArticle

yesterday • Ecotoxicology and environmental safety

T-2 toxin may cause cartilage cell damage by affecting energy production controlled by SIRT1 and PGC-1αSIRT1/PGC-1α-regulated mitochondrial biogenesis is involved in T-2 toxin-induced chondrocyte injury.

🎖️ Top 10% JournalArticle

yesterday • Journal of molecular neuroscience : MN

Genetic and Molecular Links Between Oxidative Stress and Brain Degeneration: From Gene Control to Disease ProcessesMulti-omics Insights into Oxidative Stress-related Genes and Neurodegenerative Diseases: From Epigenetic Regulation to Pathogenic Pathways.

📖 Top 20% JournalArticle

yesterday • Translational neurodegeneration

Different Activities of the PINK1-Parkin System in Various SpeciesSpecies-dependent activities of the PINK1-parkin axis.

🥈 Top 2% JournalArticle

yesterday • Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Machine learning finds cell recycling markers linked to small blood vessel damage in heart injury from blood flow loss and returnMachine learning identifies autophagy biomarkers driving microvascular injury in cardiac ischemia/reperfusion.

📖 Top 50% JournalArticle

yesterday • Neuron

A molecular pathway linking body signals to thinking problems in women during midlifeA miR-10a-5p-γCaMKII axis links periphery-to-brain signaling to cognitive vulnerability during female midlife.

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yesterday • Neurobiology of disease

Early signs of cell aging and treatment targets in a mouse model of ALS with TDP-43 mutationCellular senescence is an early feature and therapeutic target in amyotrophic lateral sclerosis TDP-43Q331K mice.

Article

yesterday • Fitoterapia

Modified Hu-lu-ba-wan and trigonelline may improve diabetic kidney tubule damage by boosting mitochondrial quality control through PACS2-regulated contactsModified Hu-lu-ba-wan and its active component trigonelline ameliorate diabetic renal tubular injury via enhancing PACS2-regulated mitochondria-endoplasmic reticulum contacts and mitophagy.

📖 Top 50% JournalArticle

yesterday • Nucleus (Austin, Tex.)

Structure and behavior of chromosome ends during cell divisionTelomeres in mitosis: organization and dynamics.

🎖️ Top 10% JournalArticle

2 days ago • FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Interferon Regulatory Factor 1 May Reduce Fat Cell Formation and Increase Self-Cleaning in Bone Marrow Stem Cells to Help Relieve Bone Loss-related Fat BuildupInterferon Regulatory Factor 1 Inhibits the Adipogenic Differentiation of BMSCs via the AMPK-mTOR Signaling Axis and Induces Their Autophagy to Alleviate Osteoporosis-Related Bone Marrow Adiposity.

Article

2 days ago • Journal of internal medicine

Understanding longer life and healthy years by looking at population aging in a positive wayA demographic perspective on longevity and healthspan: Rethinking population ageing through a positive and prospective lens.

🥉 Top 5% JournalArticle

2 days ago • Genes & diseases

Lactylation's role in metabolism, gene control, and cell death in heart tissue damage after blood flow returnsLactylation: Metabolic epigenetic regulation and cell death mechanisms in myocardial ischemia‒reperfusion injury.

🎖️ Top 10% JournalArticle

2 days ago • Archives of physiology and biochemistry

How Different Types of Exercise Affect Muscle TFEB Protein Movement Between Cell Nucleus and CytoplasmPost transcriptional modification regulation of skeletal muscle TFEB protein nuclear cytoplasmic transport based on different exercise modes in computer biomedical research.

📖 Top 30% JournalArticle

2 days ago • Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics

Key Cellular Pathways May Trigger Inflammation in Eye Surface Cells Caused by Benzalkonium ChloridemTOR/Autophagy//NF-κB Axis Drives Benzalkonium Chloride-Induced Inflammatory Response in Corneal Epithelial Cells.

📖 Top 50% JournalArticle

2 days ago • Aging

Reducing the enzyme Pla2g15 lowers certain fat molecules and aging signs in kidney cellsTargeting phospholipase Pla2g15 reduces long-chain BMP phospholipids abundance and senescence in kidney cells.

📖 Top 20% JournalArticle

2 days ago • Epigenomics

Epigenetic aging is not closely linked to fitness in heart failure patients: a pilot studyEpigenetic age acceleration is not strongly associated with cardiorespiratory fitness in heart failure: a pilot study.

📖 Top 30% JournalArticle

2 days ago • Journal of visualized experiments : JoVE

Nerve damage linked to diabetes may cause digestive problemsDiabetes-Associated Enteric Neuropathy: An Overlooked Driver of Gastrointestinal Dysfunction.

📖 Top 50% JournalVideo-Audio Media

3 days ago • Molecular genetics and genomics : MGG

USP22 may reduce aging in bone marrow stem cells caused by oxidative stress by keeping SPI1 protein stableUSP22 alleviates oxidative stress-induced BMSCs senescence by stabilizing SPI1 protein.

📖 Top 50% JournalArticle

3 days ago • Nature medicine

Biological aging clocks differ by sex across organs and molecular dataSex-specific biological aging clocks across organs and omics.

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3 days ago • Nature communications

Protein changes that occur together as cells age and stop dividingQuantitative proteomics reveals coordinated changes in the proteome during replicative senescence.

🥈 Top 2% JournalResearch Support, Non-U.S. Gov't

3 days ago • Molecular biomedicine

Betaine helps protect the liver by boosting cell cleanup and antioxidant defenses through chemical changesBetaine-driven Keap1 methylation promotes p62-mediated autophagy and Nrf2 stabilization to alleviate glutathione-dependent redox dyshomeostasis in liver injury.

🥉 Top 5% JournalArticle

3 days ago • Pharmacological research

Aging of muscle-supporting cells through specific protein changes slows muscle healing after steroid injuryCellular senescence of fibro-adipogenic progenitors by STAT5A/GFPT2/O-GlcNAcylation impairs muscle recovery after glucocorticoid-induced injury.

🥉 Top 5% JournalArticle

3 days ago • Restorative neurology and neuroscience

Resveratrol supports memory area energy function and prevents nerve cell damage to improve thinking problems linked to diabetes through Sirt1/Shh signalingResveratrol Maintains Hippocampal Mitochondrial Function and Inhibits Neuronal Ferroptosis to Improve Diabetes-Associated Cognitive Dysfunction via Sirt1/Shh Signaling.

📖 Top 50% JournalArticle

3 days ago • Journal of photochemistry and photobiology. B, Biology

MDL800, a SIRT6 activator, may reduce UV-related skin aging by lowering oxidative stress, DNA damage, and collagen lossMDL800, an allosteric SIRT6 activator, ameliorates UV-induced skin photoaging by attenuating oxidative stress, DNA damage, and collagen degradation.

📖 Top 30% JournalArticle

3 days ago • Pharmacological research

Changes in HMGB1 location over time affect organelle interactions and guide precise drug targeting in diabetic blood vessel diseaseSpatiotemporal redistribution of HMGB1 shapes organelle interactome dysfunction and informs precision pharmacological targeting in diabetic vascular disease.

🥉 Top 5% JournalArticle

3 days ago • Autophagy

How the AMBRA1-RMC1-HUWE1 system controls tagging of mitochondria in specific cell areasSpatial control of mitochondrial ubiquitination by the AMBRA1-RMC1-HUWE1 axis.

🥈 Top 2% JournalArticle

3 days ago • Science advances

A blood vessel cell pathway linked to blood vessel decline and overall agingEndothelial C/EBPβ/AEP pathway drives vascular deterioration and systemic aging.

🥈 Top 2% JournalArticle

3 days ago • GeroScience

Blood levels of NAD+ linked to frailty in older adults living in the communityAssociation between whole-blood NAD+ concentration and frailty in community-dwelling older adults: the Itabashi Longitudinal Study on Aging.

🎖️ Top 10% JournalArticle

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