Latest Longevity & Aging Research Papers

yesterday • Differentiation; research in biological diversity

Targeting NNMT to treat scarring in the heart, liver, kidneys, and lungsNNMT as a therapeutic target in fibrosis: Insights from the heart, liver, kidneys, and lungs

📖 Top 30% JournalArticle

yesterday • Frontiers in endocrinology

Cell aging and metabolism changes in type 2 diabetes: underlying processes and possible treatmentsCellular senescence and metabolic aging in type 2 diabetes: mechanistic insights and translational implications

🎖️ Top 10% JournalFulltext (Open License)Article

yesterday • Drug design, development and therapy

mTOR Signaling Pathway in Antiphospholipid Syndrome: Pathogenesis and Potential Therapeutic TargetsmTOR Signaling Pathway in Antiphospholipid Syndrome: Pathogenesis and Potential Therapeutic Targets

📖 Top 20% JournalArticle

yesterday • Aging

Faster biological aging linked to brain scans of aging and Alzheimer's diseaseAssociation of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer’s disease neurodegeneration

📖 Top 20% JournalArticle

yesterday • Cureus

Metformin's effects on cell energy and damage in age-related macular degenerationEffects of Metformin on Mitochondrial Health and Oxidative Stress in Age-Related Macular Degeneration: A Systematic Review

Article

yesterday • Biochimica et biophysica acta. Molecular basis of disease

Using silibinin to activate GHSR-1α, boost mitochondrial cleanup, and protect kidney tubules in diabetic kidney diseaseTargeting GHSR-1α with silibinin to enhance mitophagy and prevent tubular injury in diabetic kidney disease

Article

yesterday • Free radical biology & medicine

Transplanting Mitochondria Protects Eye Nerve Cells and Supports Nerve Repair in the Central Nervous SystemMitochondria Transplantation Preserves Retinal Ganglion Cells and Promotes CNS Axonal Regeneration

🥉 Top 5% JournalArticle

yesterday • Journal of assisted reproduction and genetics

How mTOR signaling affects the health of mammalian egg cellsThe role of mTOR signaling in regulating the quality of mammalian oocytes

📖 Top 20% JournalArticle

yesterday • Molecular cell

How species-specific cutting of the cell cleanup helper p62 influences responses to TNFSpecies-specific cleavage of the autophagy adaptor p62 dictates responses to TNF

Article

yesterday • Acta pharmacologica Sinica

ADT-OH helps clear damaged mitochondria and reduces inflammation signaling in brain immune cellsADT-OH promotes mitophagy and suppresses the cytosolic mtDNA-cGAS-STING inflammatory cascade in microglia

🥉 Top 5% JournalArticle

yesterday • Cell metabolism

Certain fats cause aging cells to die through iron-dependent cell damagePolyunsaturated lipids kill senescent cells by ferroptosis

🥇 Top 1% JournalArticle

2 days ago • Aging cell

Preserving NAD to Slow Cell Aging and Start Muscle and Bone RepairDouble‐Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration

🥉 Top 5% JournalFulltext (Open License)Article

2 days ago • Journal of molecular medicine (Berlin, Germany)

Effects of short-term blue light exposure on the skin's internal clock and aging markers in skin cellsImpact of acute blue light irradiation on the molecular clock and markers associated with photoaging in skin cell models

🎖️ Top 10% JournalArticle

2 days ago • Bone research

Mitochondrial DNA in bone surface cells may cause slower bone healing with agePeriosteal mitochondria DNA structures drive aging-associated poor skeletal repair

🥈 Top 2% JournalFulltext (Open License)Article

2 days ago • Molecular biomedicine

High-energy radiation reduces natural killer cells’ ability to clear aging intestinal cells in miceHigh-linear energy transfer radiation disrupts natural killer cell surveillance of senescent intestinal cells in the mouse intestine

🥉 Top 5% JournalFulltext (Open License)Article

2 days ago • Cureus

Overlap Between Alzheimer's Disease and Depression in Brain DegenerationThe Crossroads of Neurodegeneration: Exploring the Overlap Between Alzheimer's Disease and Depression

Article

2 days ago • Cell death and differentiation

Shoc2 controls new lymphatic vessel growth by reducing immune responses linked to mTORC1Signaling scaffold Shoc2 regulates lymphangiogenesis by suppressing mTORC1-mediated IFN responses

🥇 Top 1% JournalArticle

2 days ago • Aging

Developing practical ways to address human aging (12th ARDD meeting, 2025)Toward actionable interventions in human aging (12th ARDD meeting, 2025)

📖 Top 20% JournalArticle

2 days ago • Journal of biochemical and molecular toxicology

How Cell Cleaning Processes Help and Harm in Heart Muscle DiseaseFrom Defence to Dysfunction: The Dual Role of Autophagy and Mitophagy in Cardiomyopathy

📖 Top 30% JournalArticle

2 days ago • Journal of advanced research

How the lymphatic system affects healing, cancer, and agingFrom repair to disease: lymphatic contributions to regeneration, cancer and ageing

🥉 Top 5% JournalArticle

2 days ago • Cytokine & growth factor reviews

The two roles of MIF in aging and cell agingDual role of MIF in aging and cellular senescence

🥉 Top 5% JournalArticle

2 days ago • Human cell

AKR1B10 may promote liver fat buildup and inflammation in metabolic fatty liver disease by blocking cell cleanup through the PI3K/AKT pathwayAKR1B10 drives hepatic steatosis and inflammation in metabolic dysfunction-associated steatotic liver disease via PI3K/AKT-mediated autophagy suppression

📖 Top 20% JournalArticle

2 days ago • Cell chemical biology

Different ways huntingtin protein clumps with varying polyQ lengths disrupt cell cleanupDistinct autophagy impairment mechanisms of huntingtin aggregates with different polyQ lengths

🥉 Top 5% JournalArticle

2 days ago • Critical reviews in food science and nutrition

Ginsenosides in food: their production, health benefits, and use for longer lifeDietary ginsenosides for longevity: from biosynthesis and bioactive potential to functional food applications

🥉 Top 5% JournalArticle

2 days ago • Apoptosis : an international journal on programmed cell death

SIRT1-controlled removal of damaged mitochondria reduces fat-induced cell death in diabetic kidney diseaseSIRT1-regulated mitophagy mitigates lipotoxicity-induced ferroptosis in diabetic kidney disease

🥉 Top 5% JournalArticle

2 days ago • GeroScience

Faster biological aging is linked to quicker development of multiple health conditionsAccelerated biological aging is associated with faster multimorbidity progression: a UK biobank study

🎖️ Top 10% JournalArticle

2 days ago • Chemical communications (Cambridge, England)

Fluorescent probes for tracking changes in mitochondrial thickness during mitophagySilicon rhodamine-based fluorescent probes for monitoring mitochondrial viscosity dynamics during mitophagy

📖 Top 20% JournalArticle

3 days ago • Journal of cellular and molecular medicine

Molecular profiles reveal aging signs in bone-forming cells from Osteogenesis Imperfecta that are reduced by 4-PBAOMICS Profiling Identifies Signatures of Senescence in Osteogenesis Imperfecta Osteoblasts Counteracted by 4‐PBA

📖 Top 20% JournalFulltext (Open License)Article

3 days ago • Genes & diseases

Interaction between cell recycling and iron-related cell death in diabetesCrosstalk between autophagy and ferroptosis in diabetes

🎖️ Top 10% JournalArticle

3 days ago • Materials today. Bio

Tiny mitochondria outside cells change the wound environment by removing harmful molecules without entering cellsExtracellular biogenic nanoscale mitochondria reprogram the wound microenvironment via ROS scavenging independent of cellular uptake

🥉 Top 5% JournalArticle

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