Latest Longevity & Aging Research Papers

yesterday • GeroScience

Targeting the nitric oxide signaling pathway in blood vessel problems related to aging: a review of animal studiesTargeting the NO-cGMP axis in age-related vascular dysfunction: a systematic review and meta-analysis of preclinical animal studies.

🎖️ Top 10% JournalArticle

2 days ago • Pharmacology

How NLRP3 inflammasome and cell cleanup processes work together in heart diseasesThe co-regulation of NLRP3 inflammasome and autophagy for cardiovascular diseases.

📖 Top 30% JournalArticle

2 days ago • Molecular biology reports

Calreticulin's role in managing cell stress, protein balance, calcium levels, and immune cleanupCalreticulin as a stress-responsive integrator of ER proteostasis, calcium homeostasis, and immune clearance.

📖 Top 30% JournalArticle

2 days ago • Seminars in cell & developmental biology

How nutrient-sensing pathways in adult stem cells help control balance, aging, and diseaseNutrient-sensing pathways in adult stem cells: Orchestrating homeostasis, aging, and disease.

Article

2 days ago • Ageing research reviews

How Aging Affects the Connection Between Heart and Brain Blood Vessel DiseasesAging at the neurovascular interface: an integrative framework linking cardiovascular and cerebrovascular diseases.

🥈 Top 2% JournalArticle

2 days ago • Doklady. Biochemistry and biophysics

Biochemical Changes and Shorter Cell Aging Markers in Javanese Macaques Linked to Social IsolationBiochemical Adaptation and Telomere Shortening in Javanese Macaques in Response to Social Isolation.

Article

2 days ago • Medical gas research

How oxidative stress, aging, metabolism, SIRT1, and gut bacteria relate to brain and heart changes linked to memory lossOxidative stress, aging, metabolism, SIRT1, and the gut microbiota: the neurocardiac basis of cognitive loss.

📖 Top 30% JournalArticle

2 days ago • Clinical and experimental reproductive medicine

Nicotinamide mononucleotide's potential to support ovarian health based on preclinical studiesThe impact of nicotinamide mononucleotide on ovarian health: A comprehensive literature review of preclinical evidence and therapeutic potential.

📖 Top 50% JournalArticle

2 days ago • The Journal of endocrinology

Chloroquine reduces rapamycin-caused fatty liver in mice through a pathway involving ERRαRapamycin-induced fatty liver in mice is attenuated by chloroquine co-treatment in an ERRα-dependent manner.

Article

2 days ago • Neurochemistry international

Catalpol May Protect Brain Cells from MPP+ Damage by Boosting Mitochondrial Cleanup and Survival PathwaysCatalpol Protects Against MPP+-Induced Neurotoxicity by Targeting PINK1/DJ-1-Mediated Mitophagy and the TrkB/Akt/BDNF/Bcl-2 Axis.

Article

2 days ago • International journal of biological macromolecules

Structure and anti-aging effects of two sugar compounds from Trillium tschonoskii and how their structures relate to their activityStructural characterization and anti-aging activity of two polysaccharides from Trillium tschonoskii: Insights into their structure-activity relationships.

📖 Top 20% JournalArticle

2 days ago • Molecular neurobiology

Neurons Die When Multiple Signals Combine, Not from a Single CauseNeurons Die Not by One Hit, but by Signaling Convergence.

🎖️ Top 10% JournalArticle

2 days ago • Neurobiology of disease

Nerve damage in mice missing GBA1 in their nerve-supporting Schwann cellsPeripheral neuropathy in a mouse model lacking GBA1 in Schwann cells.

Article

2 days ago • Human reproduction (Oxford, England)

Therapies targeting cell energy centers in assisted reproduction: challenges and possible solutionsMitochondria-targeted therapeutic strategies in assisted reproduction: challenges and potential solutions.

Article

3 days ago • Aging cell

Activating the Lactate Receptor GPR81 May Reduce Aging Signs and Improve Muscle Function in Cell and Accelerated Aging ModelsActivation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging.

🥉 Top 5% JournalArticle

3 days ago • Naunyn-Schmiedeberg's archives of pharmacology

Changes over time in drug strategies using natural and designed compounds to control cell recycling in brain diseasesPharmacological evolution of natural product-based and chemically engineered autophagy-modulating strategies in neurodegenerative diseases: a bibliometric mapping analysis (2006-2025).

📖 Top 30% JournalArticle

3 days ago • Experimental gerontology

Brain aging clocks: New methods and underlying cell processesBrain aging clocks: From methodological advances to cellular mechanisms.

Article

4 days ago • Journal of pharmaceutical analysis

Flavonoids from Shenrong Guben Huanshao Pill may improve age-related mitochondrial problems by changing metabolism through NDUFV2 and LDHBFlavonoid compounds from Shenrong Guben Huanshao Pill alleviates senescence-associated mitochondrial dysfunction through NDUFV2 and LDHB mediated metabolic reprogramming.

Article

4 days ago • Fundamental research

How small molecules control cell cleanup: actions, treatment possibilities, and challenges in diseasesSmall-molecule autophagy modulators: Mechanisms, therapeutic potential, and development challenges in pathological settings.

📖 Top 20% JournalArticle

4 days ago • Frontiers in aging

New Treatments Targeting Cell Aging to Improve Lung Health in People with Metabolic DiseasesBreaking barriers in pulmonary health of patients with metabolic diseases: senolytics and beyond.

🎖️ Top 10% JournalArticle

4 days ago • Frontiers in immunology

How Metabolism Affects RNA Changes in Rheumatoid Arthritis: From Joint Stress to Harmful Cell AdaptationMetabolic control of RNA methylation in rheumatoid arthritis: from synovial stress to pathogenic cellular adaptation.

🥉 Top 5% JournalArticle

4 days ago • Frontiers in cell and developmental biology

CNOT11 loss is linked to self-cleaning cell processes and inflammation signaling in cancer cellsCNOT11 depletion is associated with autophagy-related responses and IL-6-JAK-STAT signaling in cancer cells.

🎖️ Top 10% JournalArticle

4 days ago • bioRxiv : the preprint server for biology

Boosting Beclin1 by genes or drugs may prevent heart and blood vessel damage caused by aldosteroneGENETIC AND PHARMACOLOGIC ACTIVATION OF BECLIN1 PREVENTS ALDOSTERONE-INDUCED CARDIOVASCULAR DAMAGE.

Preprint

4 days ago • bioRxiv : the preprint server for biology

Targeting IGFBP5/IGF1, THPO, and P38 MAPK signaling may be effective treatments for mitochondrial energy disorders and bone cancerTargeted modulation of IGFBP5/IGF1, THPO, and P38 MAPK signaling are potent therapeutic strategies generalizable for mitochondrial respiratory chain disease and osteosarcoma.

Preprint

4 days ago • bioRxiv : the preprint server for biology

KIF1A protein is needed for waste removal inside human nerve cellsKIF1A-mediated trafficking is required for neuronal autophagy in human neurons.

Preprint

4 days ago • ACS omega

Changes in Energy Use of Lab-Grown Blood Vessel Muscle Cells from Stem CellsMitochondrial Function Changes in hiPSCs-Derived Vascular Smooth Muscle Cells.

📖 Top 30% JournalArticle

4 days ago • GeroScience

Aging heart cells help blood clots form and reduce clot breakdownSenescent cardiac cells promote thrombus formation and impair fibrinolysis.

🎖️ Top 10% JournalArticle

4 days ago • Journal of ethnopharmacology

Asiaticoside may reduce aging of blood vessel cells in diabetic eye disease by boosting cell cleanup through the PI3K/AKT/mTOR pathwayAsiaticoside attenuates endothelial cells senescence in diabetic retinopathy via CCND1-mediated mitophagy through the PI3K/AKT/mTOR pathway.

📖 Top 20% JournalArticle

4 days ago • Translational research : the journal of laboratory and clinical medicine

A Continuous Cell Repair Cycle May Drive Lung Scarring ProgressionA Self-Sustaining Repair Circuit Drives the Progression of Pulmonary Fibrosis.

🥉 Top 5% JournalArticle

4 days ago • Brain : a journal of neurology

Widespread problems with energy production in muscle cells in inclusion body myositisMultilevel impairment of mitochondrial respiration in inclusion body myositis.

Article

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