Longevity & Aging Research Papers | OpenScience.ink

5 days ago • Molecular neurobiology

Mitochondrial Problems Linked to α-Synuclein Toxicity in Lab Models of Protein ClumpsMitochondrial Dysfunction as a Convergent Mechanism of α-Synuclein Toxicity: A Systematic Review of In Vitro Fibrillar Models.

🎖️ Top 10% JournalSystematic Review

4 days ago • Calcified tissue international

Drugs Targeting Cell Aging for Age-Related Muscle and Bone Disorders: A Review of Laboratory StudiesSenotherapeutics for Age-Related Musculoskeletal Disorders: A Systematic Review of Preclinical Evidence.

📖 Top 20% JournalSystematic Review

1 week ago • European journal of clinical investigation

Mitochondrial DNA Levels and Related Genes in Sudden and Stable Heart Artery DiseaseMitochondrial DNA Copy Number and Mitochondrial Homeostasis Genes in Acute and Stable Coronary Artery Disease.

📖 Top 20% JournalObservational Study

2 weeks ago • Cell metabolism

A fat tissue signal controlled by NAD+ helps protect muscles from wastingAn NAD+-responsive adipose signal coordinates inter-organ defense against muscle atrophy.

🥇 Top 1% JournalArticle

4 weeks ago • Neurochemical research

Electroacupuncture's effects on inflammation linked to aging-related memory loss: Combined analysis of clinical trialsElectroacupuncture Targeting the NLRP3 Inflammasome in Senescence‑associated Cognitive Impairment: Mechanistic Synthesis and Meta‑analysis of Clinical Randomized Controlled Trials.

📖 Top 20% JournalMeta-Analysis

4 weeks ago • Nature aging

Reduced cell cleanup by support proteins in aging weakens immune cell removal of old cellsDecline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells.

🥇 Top 1% JournalArticle

3 weeks ago • Environmental health perspectives

Links Between Green Space, Air Pollution, and Different Patterns of Biological AgingAssociations of Green Space and Air Pollution Mixture with Heterogeneous Biological Aging Patterns.

🥉 Top 5% JournalArticle

3 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Age-Related Loss of Lamin B1 May Harm Bone Formation by Triggering Cell Death Through Mitochondrial Division Controlled by SLC7A11Age-Related Lamin B1 Deficiency Activates SLC7A11-Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission.

🥈 Top 2% JournalArticle

3 weeks ago • Aging cell

Long-Term Senolytic Treatment and Aerobic Exercise Reduce Cell Aging and Improve Heart Function in Older AdultsChronic Senolytic Treatment and/or Aerobic Exercise Reduce Senescence and Improve Myocardial Function During Aging in the Heart.

🥉 Top 5% JournalArticle

2 weeks ago • Aging cell

Activating SIRT6 may improve aging spine disc healthSIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine.

🥉 Top 5% JournalFulltext (Open License)Article

2 weeks ago • Biology

Milk Protein Peptides Reduce Immune Aging and Inflammation in an Aging Mouse ModelCasein Hydrolysate Peptides Attenuate Immunosenescence and Inflammaging in a D-Galactose-Induced Mouse Model of Aging.

📖 Top 20% JournalFulltext (Open License)Article

2 weeks ago • International journal of molecular sciences

Slow Release and Active Effects of Combined Quercetin and Resveratrol Carriers in Hummus During Simulated DigestionDual-Loaded Quercetin-Resveratrol Niosomes: Sustained In Vitro Release and Retained Bioactivity in Hummus During Simulated Gastrointestinal Digestion.

📖 Top 20% JournalFulltext (Open License)Article

2 weeks ago • Cells

Activating Mitochondrial Fusion Slows Aging in Nematode WormsMitofusin Activation Delays Aging in Caenorhabditis elegans.

🎖️ Top 10% JournalFulltext (Open License)Article

2 weeks ago • International journal of molecular sciences

Ciprofloxacin causes oxidative stress that leads to aging-like changes in human skin cells grown in the labCiprofloxacin-Induced Oxidative Stress Promotes a Senescence-like Phenotype in Human Fibroblasts In Vitro.

📖 Top 20% JournalFulltext (Open License)Article

2 weeks ago • International journal of molecular sciences

How Mitochondrial Cleanup and Iron-Related Cell Death May Work Together in Kidney Tubule Damage from DiabetesMitophagy and Ferroptosis in Diabetic Kidney Disease: A Hypothesis of Their Synergistic Interplay in Renal Tubular Injury-A Narrative Review.

📖 Top 20% JournalFulltext (Open License)Article

2 weeks ago • International journal of molecular sciences

Gastrodin’s role in controlling microglial self-cleaning and inflammatory cell death through the energy and inflammation pathwaysGastrodin and Microglial Autophagy-Pyroptosis Crosstalk: Evidence and Hypotheses Involving the AMPK/mTOR/NLRP3 Axis.

📖 Top 20% JournalFulltext (Open License)Article

2 weeks ago • International journal of molecular sciences

Using Network Analysis to Understand How Plant Compounds Work on Multiple Targets: Combining Molecular Studies, Lab Tests, and Clinical ApplicationsNetwork Pharmacology-Guided Phytochemical Polypharmacology: Integrating Molecular Mechanisms, Experimental Validation and Clinical Translation.

📖 Top 20% JournalFulltext (Open License)Article

2 weeks ago • Cells

Disrupting Energy Control in Cells by the TBC1D15 ProteinDisrupting Mitochondrial Homeostasis via TBC1D15 Protein.

🎖️ Top 10% JournalFulltext (Open License)Article

2 weeks ago • Science advances

Astrocyte problems linked to MFN2 may lead to overactive nerve cells and depression-like behaviorsMFN2-associated astrocyte dysfunction contributes to neuronal hyperexcitability and depressive-like behaviors.

🥈 Top 2% JournalArticle

2 weeks ago • Ageing research reviews

How FOXO Proteins Relate to Aging Through Gene Regulation and DNA PackagingThe FOXO-aging axis: Epigenetic insights and chromatin mechanisms.

🥈 Top 2% JournalArticle

2 weeks ago • GeroScience

Streptococcus thermophilus changes fat metabolism to extend healthy life in Caenorhabditis elegans through a fat-regulating pathwayStreptococcus thermophilus remodels lipid metabolism to extend healthspan in Caenorhabditis elegans through NHR-49-Delta-9 desaturase axis.

🎖️ Top 10% JournalArticle

2 weeks ago • European journal of pharmacology

Ibogaine may support brain cell repair and flexibility by changing cell metabolismExtracellular flux analysis and proteomic profiling indicate ibogaine promotes synaptic plasticity and neural repair by a metabolic preconditioning mechanism.

📖 Top 20% JournalArticle

3 weeks ago • iScience

Applying urolithin A to the skin may boost cell cleanup and energy production to help skin age betterTopical application of urolithin A activates mitophagy and enhances mitochondrial function to promote skin longevity.

🎖️ Top 10% JournalArticle

3 weeks ago • Ageing research reviews

How Daily Eating Patterns Affect Metabolism, Stress Resistance, and Healthy AgingChrononutrition in the aging era: Circadian regulation of metabolism, resilience, and healthy longevity.

🥈 Top 2% JournalArticle

yesterday • Aging cell

TOP2A Helps Keep Compact DNA Stable by Supporting LMNB1 to Prevent Cell AgingTOP2A Maintains Heterochromatin Stability by Sustaining LMNB1 Expression to Counteract Senescence.

🥉 Top 5% JournalArticle

2 days ago • Aging cell

A DNA Methylation-Based Predictor of Age Tested with Real and Random Missing DataA 209-Site DNA Methylation Predictor of Chronological Age Evaluated Under Empirical and Random Missingness.

🥉 Top 5% JournalArticle

2 days ago • Aging cell

Using Rodent Safety Data to Find Potential Longevity Agents That May Boost Mitochondrial HealthRepurposing Regulatory Rodent Toxicology Safety Archives to Identify Candidate Hormetic Longevity Agents Highlights Emergent Mitochondrial Mechanisms.

🥉 Top 5% JournalArticle

2 days ago • Aging cell

Identifying Light-Based Signals Linked to Brain AgingEstablishing a Biophotonic Signature of Brain Ageing.

🥉 Top 5% JournalArticle

2 days ago • Aging cell

Long-Term Culture of Human Skin Cells Mimics Aging and Allows Testing of Anti-Aging DrugsLong-Term Post-Mitotic Culture of Human Fibroblasts Recapitulates and Accelerates Features of In Vivo Aging and Enables Dynamic Testing of Anti-Aging Compounds.

🥉 Top 5% JournalArticle

3 days ago • GeroScience

Sesaminol reduces alcohol-related aging in the colon of middle-aged mice, possibly through protective cell pathwaysSesaminol attenuates alcohol-induced colonic senescence in middle-aged mice: potential involvement of the AhR-Nrf2 axis.

🎖️ Top 10% JournalArticle

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