Longevity & Aging Research Papers

1 week ago • Nutrients

Safety and Metabolism Effects of Taking Nicotinamide Mononucleotide Supplements in AdultsSafety and Metabolism-Related Outcomes of Oral Nicotinamide Mononucleotide Supplementation in Adults: A Systematic Review and Meta-Analysis.

🎖️ Top 10% JournalSystematic Review

1 week ago • International journal of molecular sciences

Greenspace Exposure and Faster Biological Aging Measured by DNA Changes: A Review and Pathway AnalysisGreenspace Exposure and DNA Methylation Age Acceleration: A Systematic Review and Molecular Pathway Analysis.

📖 Top 20% JournalSystematic Review

3 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Frequent Sweetened Drink Intake Is Linked to Faster Biological Aging and Changes in Gut BacteriaFrequent Sweetened Beverage Consumption Is Associated With Accelerated Biological Aging: Evidence From a Population-Based Study and Gut Microbiota Analysis.

🥈 Top 2% Journal

5 days ago • Journal of hazardous materials

Swallowed microplastics that don’t enter the brain may harm nerves by disturbing gut bacteria, tryptophan metabolism, and brain immune cell cleanupOral exposure to non-brain-penetrable microplastics induces neurotoxicity via disrupting the gut microbiota-tryptophan metabolism-microglial autophagy cascade.

🥉 Top 5% JournalArticle

1 week ago • Nature aging

Long-term low valine intake improves health and lifespan differently in male and female miceLifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice.

🥇 Top 1% Journal

2 weeks ago • Cell stem cell

Vitamin C may reduce aging in primate bone marrow cells and moleculesVitamin C attenuates primate bone marrow aging at the molecular and progenitor level.

🥇 Top 1% Journal

6 days ago • GeroScience

Oral LNAD+ quickly raises NAD levels inside blood cells and boosts metabolism without increasing NAD in blood plasmaOral LNAD+ rapidly elevates whole blood intracellular NAD and metabolic flux without elevating plasma NAD: evidence from a randomized controlled trial.

🎖️ Top 10% JournalArticle

1 week ago • Aging cell

Comparing Natural and Measurement Reliability of Epigenetic Clocks and Their Links to Disease Outlook and Treatment ResponseBiological Versus Technical Reliability of Epigenetic Clocks and Implications for Disease Prognosis and Intervention Response.

🥉 Top 5% JournalArticle

1 week ago • GeroScience

Blood factors from time-restricted eating may change metabolism in blood vessel lining cellsCirculating factors induced by time-restricted eating drive metabolic reprogramming in endothelial cells.

🎖️ Top 10% Journal

2 weeks ago • Aging cell

Different impacts of Nicotinamide Riboside and Intense Exercise on Age-Related Changes in Muscle DNAThe Divergent Effects of Nicotinamide Riboside and High-Intensity Exercise Training on Skeletal Muscle Epigenetic Aging.

🥉 Top 5% Journal

2 weeks ago • GeroScience

A metabolic measure of aging linked to frailty and thinking skills across different groupsA metabolomic clock of population ageing: cross-cohort validation and associations with frailty and cognitive function.

🎖️ Top 10% Journal

1 week ago • Nature aging

Different types of aging cells show the variety of senescent cellsSenotypes define the diverse landscape of senescent cells.

🥇 Top 1% JournalArticle

1 week ago • Nature neuroscience

Build-up of damaged energy parts and recycling problems create harmful clumps in Alzheimer's diseaseMitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease.

🥇 Top 1% JournalArticle

1 week ago • Science advances

mTOR signaling helps control daily gene activity rhythms in mouse livermTOR signaling contributes to system-driven rhythmic gene expression in mouse liver.

🥈 Top 2% Journal

2 weeks ago • Nature aging

Aging cells gather CTCF protein at nuclear speckles to control alternative RNA splicingSenescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program.

🥇 Top 1% Journal

2 weeks ago • Nature aging

Blocking a specific cell pathway reduces aging-related inflammation and improves function during aging and after chemotherapyDisruption of CDK4/6-RARα-NF-κB axis attenuates senescence-associated inflammation and improves function during aging and following chemotherapy.

🥇 Top 1% Journal

2 weeks ago • Nature aging

Trained immunity connects aging of blood stem cells to inflammation in agingTrained immunity links hematopoietic stem cell aging to aging-associated inflammation.

🥇 Top 1% Journal

3 weeks ago • NPJ science of food

Differences in biological aging linked to instant versus filtered coffee in UK Biobank dataDiscrepancies between instant and filtered coffee in biological aging: evidence from the UK Biobank.

📖 Top 20% Journal

3 weeks ago • Nature communications

Cellular features and aging signs in the human lung tissueCellular hallmarks and aging clock of the human lung parenchyma.

🥈 Top 2% Journal

yesterday • GeroScience

Targeting the nitric oxide signaling pathway in blood vessel problems related to aging: a review of animal studiesTargeting the NO-cGMP axis in age-related vascular dysfunction: a systematic review and meta-analysis of preclinical animal studies.

🎖️ Top 10% JournalArticle

3 days ago • Aging cell

Activating the Lactate Receptor GPR81 May Reduce Aging Signs and Improve Muscle Function in Cell and Accelerated Aging ModelsActivation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging.

🥉 Top 5% JournalArticle

4 days ago • GeroScience

Aging heart cells help blood clots form and reduce clot breakdownSenescent cardiac cells promote thrombus formation and impair fibrinolysis.

🎖️ Top 10% JournalArticle

4 days ago • Frontiers in aging

New Treatments Targeting Cell Aging to Improve Lung Health in People with Metabolic DiseasesBreaking barriers in pulmonary health of patients with metabolic diseases: senolytics and beyond.

🎖️ Top 10% JournalArticle

4 days ago • Frontiers in immunology

How Metabolism Affects RNA Changes in Rheumatoid Arthritis: From Joint Stress to Harmful Cell AdaptationMetabolic control of RNA methylation in rheumatoid arthritis: from synovial stress to pathogenic cellular adaptation.

🥉 Top 5% JournalArticle

4 days ago • Frontiers in cell and developmental biology

CNOT11 loss is linked to self-cleaning cell processes and inflammation signaling in cancer cellsCNOT11 depletion is associated with autophagy-related responses and IL-6-JAK-STAT signaling in cancer cells.

🎖️ Top 10% JournalArticle

5 days ago • Frontiers in pharmacology

How empagliflozin and nebivolol may interact in aging-related oxidative stress and inflammationMechanistic intersections of empagliflozin and nebivolol in aging-associated redox and inflammatory pathways.

📖 Top 20% JournalArticle

5 days ago • Autophagy

Thioredoxin reductase 1 influences the recycling of cell's protein-folding centers during aging through liquid-liquid phase separationTrr1 (thioredoxin reductase 1) modulates ERphagy in aging via liquid-liquid phase separation.

🥈 Top 2% JournalArticle

5 days ago • Autophagy

Mitochondrial cleanup in neurodegeneration: interaction between parkin-dependent and independent pathwaysMitophagy in neurodegeneration: crosstalk between PRKN/parkin-dependent and PRKN-independent pathways.

🥈 Top 2% JournalArticle

6 days ago • eLife

A muscle protein complex limits muscle length growth when stretchedThe titin N2A-MARP signalosome constrains muscle longitudinal hypertrophy in response to stretch.

🥈 Top 2% JournalArticle

6 days ago • Frontiers in immunology

Autophagy’s two roles in gouty arthritis: underlying processes and treatment possibilitiesDual role of autophagy in gouty arthritis (GA): molecular mechanisms and therapeutic potential.

🥉 Top 5% JournalArticle

← prevpage 1 of 18next →