Trending Longevity & Aging Research Papers

yesterday • Frontiers in endocrinology

Cell aging and metabolism changes in type 2 diabetes: underlying processes and possible treatmentsCellular senescence and metabolic aging in type 2 diabetes: mechanistic insights and translational implications

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2 days ago • Molecular biomedicine

High-energy radiation reduces natural killer cells’ ability to clear aging intestinal cells in miceHigh-linear energy transfer radiation disrupts natural killer cell surveillance of senescent intestinal cells in the mouse intestine

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2 days ago • Bone research

Mitochondrial DNA in bone surface cells may cause slower bone healing with agePeriosteal mitochondria DNA structures drive aging-associated poor skeletal repair

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2 days ago • Aging cell

Preserving NAD to Slow Cell Aging and Start Muscle and Bone RepairDouble‐Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration

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1 week ago • Frontiers in public health

How pregnancy history and unhealthy lifestyle relate to faster biological agingAssociation of pregnancy history and unhealthy lifestyle with biological age acceleration: a large cross-sectional study

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6 days ago • npj aging

Biological age measured from images of many organs is linked to risk of death and aging-related health problemsImaging-derived biological age across multiple organs links to mortality and aging-related health outcomes

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3 days ago • Frontiers in molecular biosciences

Gene activity changes from chlorogenic acid and taurine treatment reveal how human skin cells ageTranscriptomic profiling of chlorogenic acid and taurine treatment in human skin cells provides insights into cellular senescence mechanisms

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6 days ago • 3 Biotech

Gandouling may protect the liver from scarring in Wilson disease through a specific RNA pathwayGandouling protects against hepatic fibrosis in Wilson disease through the lncRNA-SNHG7/miR-29b/DNMT3A pathway

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yesterday • Cell metabolism

Certain fats cause aging cells to die through iron-dependent cell damagePolyunsaturated lipids kill senescent cells by ferroptosis

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1 week ago • Frontiers in endocrinology

Insulin's ability to increase sugar absorption is reduced in aging human fat cellsInsulin-stimulated glucose uptake is impaired in senescent human adipocytes

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3 days ago • Journal of cellular and molecular medicine

Molecular profiles reveal aging signs in bone-forming cells from Osteogenesis Imperfecta that are reduced by 4-PBAOMICS Profiling Identifies Signatures of Senescence in Osteogenesis Imperfecta Osteoblasts Counteracted by 4‐PBA

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6 days ago • Molecular ecology

DNA Methylation Patterns Across the Genome Predict Age in Zebra Sharks and Offer Clues About How Aging Evolved in VertebratesGenome‐Wide DNA Methylation Patterns Predict Age in the Zebra Shark (Stegostoma tigrinum) and Provide Insight Into the Evolution of Vertebrate Aging

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2 days ago • GeroScience

Faster biological aging is linked to quicker development of multiple health conditionsAccelerated biological aging is associated with faster multimorbidity progression: a UK biobank study

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5 days ago • Neuromolecular medicine

Brain Aging and How SIRT1 Activators May Protect the Brain: Mechanisms and Treatment PossibilitiesSIRT1 Activators as Geroprotective Agents in Brain Aging: Mechanisms and Therapeutic Potential

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2 days ago • Aging

Developing practical ways to address human aging (12th ARDD meeting, 2025)Toward actionable interventions in human aging (12th ARDD meeting, 2025)

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yesterday • Aging

Faster biological aging linked to brain scans of aging and Alzheimer's diseaseAssociation of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer’s disease neurodegeneration

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yesterday • Acta pharmacologica Sinica

ADT-OH helps clear damaged mitochondria and reduces inflammation signaling in brain immune cellsADT-OH promotes mitophagy and suppresses the cytosolic mtDNA-cGAS-STING inflammatory cascade in microglia

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3 days ago • Journal of Alzheimer's disease : JAD

Time-Restricted Eating and Its Potential in Alzheimer's Disease: A Research InvitationTime-restricted eating in Alzheimer's disease (TREAD): A call for research

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3 days ago • Genes & diseases

The role of cell aging and possible treatments in spine disc breakdownThe role and potential therapeutic intervention of cellular senescence in intervertebral disc degeneration

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2 days ago • Critical reviews in food science and nutrition

Ginsenosides in food: their production, health benefits, and use for longer lifeDietary ginsenosides for longevity: from biosynthesis and bioactive potential to functional food applications

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2 days ago • Cytokine & growth factor reviews

The two roles of MIF in aging and cell agingDual role of MIF in aging and cellular senescence

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1 week ago • Reviews in cardiovascular medicine

How Natural Aging Relates to New Cases and Changes Over Time in Irregular HeartbeatContributions of Biological Aging to Longitudinal Incidence and Dynamic Progression of Atrial Fibrillation: A Prospective Cohort Study

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4 days ago • Ageing research reviews

Aging of Blood Vessel Lining Cells Linked to Mitochondria ProblemsEndothelial Cell Senescence and Mitochondrial Dysfunction in Vascular Ageing

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4 days ago • Ageing research reviews

How Ageing Affects the Lymphatic System and Its Impact on Immunity, Brain Health, and TreatmentsAgeing and the lymphatic system: implications for immunity, brain health, and possible therapeutic interventions

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4 days ago • Ageing research reviews

How males and females respond differently to treatments that may extend lifespanSex differences in response to longevity interventions

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3 days ago • Autophagy

Phase separation of C19orf12 controls BNIP3 protein quality and supports mitochondrial cleanup in neuronsPhase separation of C19orf12 regulates BNIP3 protein quality control and maintains neuronal mitophagy

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3 days ago • Journal of Alzheimer's disease : JAD

Shared Genetic Factors Linked to Muscle Loss and Alzheimer's DiseaseUncovering polygenic and local genetic overlap between sarcopenia and Alzheimer's disease

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6 days ago • Science advances

Longer life from lower IGF-1 signals may depend on how stable mitochondrial DNA isThe longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome

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2 days ago • Journal of advanced research

How the lymphatic system affects healing, cancer, and agingFrom repair to disease: lymphatic contributions to regeneration, cancer and ageing

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5 days ago • Ageing research reviews

Blood Vessel Aging as a Key Cause of Multiple Health ProblemsVascular aging: A central driver of multimorbidity

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