Trending Longevity & Aging Research Papers

3 days ago • Nature communications

Protein changes that occur together as cells age and stop dividingQuantitative proteomics reveals coordinated changes in the proteome during replicative senescence.

🥈 Top 2% JournalResearch Support, Non-U.S. Gov't

2 days ago • Journal of internal medicine

Understanding longer life and healthy years by looking at population aging in a positive wayA demographic perspective on longevity and healthspan: Rethinking population ageing through a positive and prospective lens.

🥉 Top 5% JournalArticle

yesterday • Journal of drug targeting

Aging Skin Cells Release Particles That Affect Skin Aging and Repair, Offering Potential Treatment OptionsSenescence-Associated Extracellular Vesicles in Skin Aging and Regeneration: From Pathophysiology to Therapeutic Opportunities.

📖 Top 20% JournalArticle

yesterday • Nucleus (Austin, Tex.)

Structure and behavior of chromosome ends during cell divisionTelomeres in mitosis: organization and dynamics.

🎖️ Top 10% JournalArticle

4 days ago • The Journal of clinical investigation

How LSD1 changes ATM to promote cell aging and organ declineLSD1-mediated demethylation of the DNA damage response factor ATM promotes senescence and organ aging.

🥈 Top 2% JournalArticle

4 days ago • Small science

A 3D Lab-Grown Human Muscle Model Showing Key Biological and Functional Signs of AgingA Biomimetic 3D Human Skeletal Muscle Microtissue for Modeling Biological and Functional Hallmarks of Aging.

🥉 Top 5% JournalArticle

3 days ago • Science advances

A blood vessel cell pathway linked to blood vessel decline and overall agingEndothelial C/EBPβ/AEP pathway drives vascular deterioration and systemic aging.

🥈 Top 2% JournalArticle

4 days ago • Health science reports

How Different Biological Age Estimates May Predict Outcomes in Breast Cancer PatientsPrognostic Value of Different Biological Age Estimation Methods in Breast Cancer Patients: A Population-Based Cohort Study Using NHANES 1999-2020.

📖 Top 50% JournalArticle

4 days ago • GeroScience

Work Stress and Healthy Aging: A Framework for the Semmelweis Study and Workplace Health ProgramWork stress and healthy aging: A conceptual framework for the Semmelweis study and the Semmelweis-EUniWell workplace health promotion model program.

🎖️ Top 10% JournalArticle

4 days ago • ACS biomaterials science & engineering

Complex Control Systems of Cell Aging: From How It Works to Diagnosis and TreatmentMultidimensional Regulatory Network of Cellular Senescence: From Mechanisms to Theranostics.

📖 Top 20% JournalArticle

yesterday • Translational neurodegeneration

Different Activities of the PINK1-Parkin System in Various SpeciesSpecies-dependent activities of the PINK1-parkin axis.

🥈 Top 2% JournalArticle

3 days ago • GeroScience

Blood levels of NAD+ linked to frailty in older adults living in the communityAssociation between whole-blood NAD+ concentration and frailty in community-dwelling older adults: the Itabashi Longitudinal Study on Aging.

🎖️ Top 10% JournalArticle

3 days ago • GeroScience

Increased activity of jumping DNA sequences distinguishes blood cell growth with DNMT3A mutations from those with TET2 mutationsRetrotransposable element derepression distinguishes DNMT3A-mutant from TET2-mutant clonal haematopoiesis.

🎖️ Top 10% JournalArticle

6 days ago • Bone research

Bone aging as a process of damage at multiple levels and ways to reverse itBone aging: a paradigm of multiscale degeneration and targeted rejuvenation.

🥈 Top 2% JournalArticle

4 days ago • The Journal of arthroplasty

Faster Biological Aging Predicts Lower Function and Higher Surgery Risk in Knee ReplacementBiological Age Acceleration Predicts Functional Decline and Surgical Risk in Knee Arthroplasty.

🥉 Top 5% JournalArticle

4 days ago • Molecular neurobiology

Non-coding RNAs and Mitochondrial Problems in Alzheimer's DiseaseNon-coding RNAs and Mitochondrial Dysfunction in Alzheimer's Disease: A Systematic Review.

🎖️ Top 10% JournalSystematic Review

3 days ago • International reviews of immunology

Aging immune system decline and organ communication problems: Possible benefits of algae-based compounds and nutrition for healthy agingImmunosenescence and immune-organ axis dysfunction: Potential of algal bioactives and nutritional interventions for healthy ageing.

📖 Top 20% JournalArticle

2 days ago • Aging

Reducing the enzyme Pla2g15 lowers certain fat molecules and aging signs in kidney cellsTargeting phospholipase Pla2g15 reduces long-chain BMP phospholipids abundance and senescence in kidney cells.

📖 Top 20% JournalArticle

5 days ago • Signal transduction and targeted therapy

Hepassocin may slow liver aging and help liver repair by activating energy controlHepassocin prevents age-related liver senescence and facilitates liver regeneration by activating AMPK.

🥇 Top 1% JournalArticle

4 days ago • Obesity surgery

Weight Loss Surgery and Changes in the Heart-Based Biological Age Difference Over TimeMetabolic and Bariatric Surgery and Change in the AI-ECG-Derived Biological-Age Gap: A Longitudinal Cohort Study.

📖 Top 20% JournalArticle

4 days ago • European journal of human genetics : EJHG

Genetic and computer analysis of changes in telomere control genes in people with bone marrow failureGenomic and computational analysis of variants in telomere regulatory genes in subjects with bone marrow failure.

🎖️ Top 10% JournalArticle

yesterday • Journal of molecular medicine (Berlin, Germany)

How early cell aging, inflammation, and cell energy communication relate to CBD’s heart-protective effects in heart failure with preserved pumping functionProspective associations of premature senescence, inflammation, and MERCSs in the cardioprotective effect of CBD in HFpEF.

🎖️ Top 10% JournalArticle

yesterday • Journal of molecular neuroscience : MN

Genetic and Molecular Links Between Oxidative Stress and Brain Degeneration: From Gene Control to Disease ProcessesMulti-omics Insights into Oxidative Stress-related Genes and Neurodegenerative Diseases: From Epigenetic Regulation to Pathogenic Pathways.

📖 Top 20% JournalArticle

3 days ago • Pharmacological research

Aging of muscle-supporting cells through specific protein changes slows muscle healing after steroid injuryCellular senescence of fibro-adipogenic progenitors by STAT5A/GFPT2/O-GlcNAcylation impairs muscle recovery after glucocorticoid-induced injury.

🥉 Top 5% JournalArticle

3 days ago • Journal of photochemistry and photobiology. B, Biology

MDL800, a SIRT6 activator, may reduce UV-related skin aging by lowering oxidative stress, DNA damage, and collagen lossMDL800, an allosteric SIRT6 activator, ameliorates UV-induced skin photoaging by attenuating oxidative stress, DNA damage, and collagen degradation.

📖 Top 30% JournalArticle

4 days ago • Inflammopharmacology

Using nano-immunomodulators to influence immune signaling pathways in Alzheimer’s and Parkinson’s diseasesPharmacological modulation of cGAS-STING-NLRP3 signaling by nano-immunomodulators in Alzheimer and Parkinson disease.

📖 Top 20% JournalArticle

4 days ago • Oral diseases

How Mouth Bacteria and Aging-Related Inflammation May Affect Gum Disease and Overall Health in Older AdultsThe Oral Microbiome-Inflammaging Axis in Elderly Periodontitis: Emerging Immunopathogenic and Systemic Mechanisms.

📖 Top 20% JournalArticle

4 days ago • Acta ophthalmologica

Faster biological aging is linked to a higher buildup of large drusenAccelerated biological ageing is associated with a large drusen burden.

🎖️ Top 10% JournalArticle

2 days ago • Epigenomics

Epigenetic aging is not closely linked to fitness in heart failure patients: a pilot studyEpigenetic age acceleration is not strongly associated with cardiorespiratory fitness in heart failure: a pilot study.

📖 Top 30% JournalArticle

3 days ago • Molecular genetics and genomics : MGG

USP22 may reduce aging in bone marrow stem cells caused by oxidative stress by keeping SPI1 protein stableUSP22 alleviates oxidative stress-induced BMSCs senescence by stabilizing SPI1 protein.

📖 Top 50% JournalArticle