Trending Longevity & Aging Research Papers

yesterday • GeroScience

Targeting the nitric oxide signaling pathway in blood vessel problems related to aging: a review of animal studiesTargeting the NO-cGMP axis in age-related vascular dysfunction: a systematic review and meta-analysis of preclinical animal studies.

🎖️ Top 10% JournalArticle

6 days ago • GeroScience

Oral LNAD+ quickly raises NAD levels inside blood cells and boosts metabolism without increasing NAD in blood plasmaOral LNAD+ rapidly elevates whole blood intracellular NAD and metabolic flux without elevating plasma NAD: evidence from a randomized controlled trial.

🎖️ Top 10% JournalArticle

1 week ago • Aging cell

Comparing Natural and Measurement Reliability of Epigenetic Clocks and Their Links to Disease Outlook and Treatment ResponseBiological Versus Technical Reliability of Epigenetic Clocks and Implications for Disease Prognosis and Intervention Response.

🥉 Top 5% JournalArticle

4 days ago • Frontiers in aging

New Treatments Targeting Cell Aging to Improve Lung Health in People with Metabolic DiseasesBreaking barriers in pulmonary health of patients with metabolic diseases: senolytics and beyond.

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3 days ago • Aging cell

Activating the Lactate Receptor GPR81 May Reduce Aging Signs and Improve Muscle Function in Cell and Accelerated Aging ModelsActivation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging.

🥉 Top 5% JournalArticle

1 week ago • Nature aging

Different types of aging cells show the variety of senescent cellsSenotypes define the diverse landscape of senescent cells.

🥇 Top 1% JournalArticle

2 days ago • Medical gas research

How oxidative stress, aging, metabolism, SIRT1, and gut bacteria relate to brain and heart changes linked to memory lossOxidative stress, aging, metabolism, SIRT1, and the gut microbiota: the neurocardiac basis of cognitive loss.

📖 Top 30% JournalArticle

2 days ago • Ageing research reviews

How Aging Affects the Connection Between Heart and Brain Blood Vessel DiseasesAging at the neurovascular interface: an integrative framework linking cardiovascular and cerebrovascular diseases.

🥈 Top 2% JournalArticle

5 days ago • Autophagy

Thioredoxin reductase 1 influences the recycling of cell's protein-folding centers during aging through liquid-liquid phase separationTrr1 (thioredoxin reductase 1) modulates ERphagy in aging via liquid-liquid phase separation.

🥈 Top 2% JournalArticle

6 days ago • Frontiers in aging

Automated creation of personalized aging patterns using DyViA-GANAutomated generation of personalized trajectories of aging phenotypes with DyViA-GAN.

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2 days ago • Molecular neurobiology

Neurons Die When Multiple Signals Combine, Not from a Single CauseNeurons Die Not by One Hit, but by Signaling Convergence.

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4 days ago • GeroScience

Aging heart cells help blood clots form and reduce clot breakdownSenescent cardiac cells promote thrombus formation and impair fibrinolysis.

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1 week ago • GeroScience

Using DNA-based aging markers in diet and aging studies: practical steps, participant views, and study planningEpigenetic aging biomarkers in dietary geroscience: feasibility, participant perceptions, and trial design considerations.

🎖️ Top 10% JournalArticle

2 days ago • Clinical and experimental reproductive medicine

Nicotinamide mononucleotide's potential to support ovarian health based on preclinical studiesThe impact of nicotinamide mononucleotide on ovarian health: A comprehensive literature review of preclinical evidence and therapeutic potential.

📖 Top 50% JournalArticle

6 days ago • Frontiers in immunology

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6 days ago • iMeta

Bazi Bushen Capsule may improve fertility by supporting energy health in aging womb liningBazi Bushen Capsule restores fertility by targeting mitochondrial health in aging endometrium.

🥇 Top 1% JournalArticle

6 days ago • Autophagy

Using diet to improve cell cleanup reduces age-related heart scarring and stiffnessTargeting chaperone-mediated autophagy by nutritional interventions mitigates age-related cardiac fibrosis and diastolic dysfunction.

🥈 Top 2% JournalArticle

2 days ago • International journal of biological macromolecules

Structure and anti-aging effects of two sugar compounds from Trillium tschonoskii and how their structures relate to their activityStructural characterization and anti-aging activity of two polysaccharides from Trillium tschonoskii: Insights into their structure-activity relationships.

📖 Top 20% JournalArticle

5 days ago • Ageing research reviews

Cell Aging Linked to Both Getting Older and Coronary Artery DiseaseCellular senescence at the bidirectional interface between ageing and coronary artery disease.

🥈 Top 2% JournalArticle

5 days ago • Ageing research reviews

Physical and Mechanical Features of Cell Aging and Their Use in TreatmentsThe Physical Senotype in cellular senescence: Mechanical and physical strategies for senotherapy.

🥈 Top 2% JournalArticle

5 days ago • Frontiers in pharmacology

How empagliflozin and nebivolol may interact in aging-related oxidative stress and inflammationMechanistic intersections of empagliflozin and nebivolol in aging-associated redox and inflammatory pathways.

📖 Top 20% JournalArticle

4 days ago • Fundamental research

How small molecules control cell cleanup: actions, treatment possibilities, and challenges in diseasesSmall-molecule autophagy modulators: Mechanisms, therapeutic potential, and development challenges in pathological settings.

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4 days ago • Molecular neurobiology

Fixing Energy Problems in Brain Immune Cells as a New Approach to Treat Brain Degenerative DiseasesTargeting Mitochondrial Dysfunction in Microglia: A New Frontier for Treating Neurodegenerative Diseases.

🎖️ Top 10% JournalArticle

4 days ago • Molecular neurobiology

How Waste Removal and Inflammation in Brain Support Cells Are Linked in Alzheimer's DiseaseThe Glial Autophagy-Lysosomal-Inflammation Axis in Alzheimer's Disease: a Unifying Mechanistic Framework.

🎖️ Top 10% JournalArticle

1 week ago • International journal of biological sciences

Cleaning, Repairing, and Soothing: Promising Approaches to Treat Aging-Related DiseasesCleaning, Chasing and Calming: Promising Paradigms of Senotherapy in Aging-Related Diseases.

🥉 Top 5% JournalArticle

1 week ago • Nature reviews. Genetics

How Genes and Their Regulation Control Cell AgingGenomic, epigenomic and transcriptomic regulation of cellular senescence.

🥇 Top 1% JournalArticle

6 days ago • Frontiers in cell and developmental biology

Stress and its link to brain cell cleaning processes that may affect lifelong disease riskThe embedding of stress: mitophagy as a mechanism for the central nervous system (CNS) programming and lifelong disease vulnerability.

🎖️ Top 10% JournalArticle

2 days ago • Molecular biology reports

Calreticulin's role in managing cell stress, protein balance, calcium levels, and immune cleanupCalreticulin as a stress-responsive integrator of ER proteostasis, calcium homeostasis, and immune clearance.

📖 Top 30% JournalArticle

5 days ago • Immunity & ageing : I & A

Cell aging as a hidden cause of long-lasting skin inflammationCellular senescence: the "hidden driver" in chronic inflammatory skin disorders.

🎖️ Top 10% JournalArticle

5 days ago • European journal of clinical nutrition

Intermittent fasting: Effects, how it works, and important precautions for health and daily lifeIntermittent fasting: Impact, mechanisms and cautions across medical and lifestyle domains.

📖 Top 20% JournalArticle