Trending Longevity & Aging Research Papers

4 days ago • Calcified tissue international

Drugs Targeting Cell Aging for Age-Related Muscle and Bone Disorders: A Review of Laboratory StudiesSenotherapeutics for Age-Related Musculoskeletal Disorders: A Systematic Review of Preclinical Evidence.

📖 Top 20% JournalSystematic Review

2 days ago • Aging cell

Long-Term Culture of Human Skin Cells Mimics Aging and Allows Testing of Anti-Aging DrugsLong-Term Post-Mitotic Culture of Human Fibroblasts Recapitulates and Accelerates Features of In Vivo Aging and Enables Dynamic Testing of Anti-Aging Compounds.

🥉 Top 5% JournalArticle

yesterday • Aging cell

TOP2A Helps Keep Compact DNA Stable by Supporting LMNB1 to Prevent Cell AgingTOP2A Maintains Heterochromatin Stability by Sustaining LMNB1 Expression to Counteract Senescence.

🥉 Top 5% JournalArticle

2 days ago • Aging cell

A DNA Methylation-Based Predictor of Age Tested with Real and Random Missing DataA 209-Site DNA Methylation Predictor of Chronological Age Evaluated Under Empirical and Random Missingness.

🥉 Top 5% JournalArticle

2 days ago • Aging cell

Using Rodent Safety Data to Find Potential Longevity Agents That May Boost Mitochondrial HealthRepurposing Regulatory Rodent Toxicology Safety Archives to Identify Candidate Hormetic Longevity Agents Highlights Emergent Mitochondrial Mechanisms.

🥉 Top 5% JournalArticle

2 days ago • Aging cell

Identifying Light-Based Signals Linked to Brain AgingEstablishing a Biophotonic Signature of Brain Ageing.

🥉 Top 5% JournalArticle

yesterday • Ageing research reviews

The Role of the Thioredoxin System in Cell Aging and Its Potential as a Treatment TargetThe Thioredoxin System in Cellular Senescence and Ageing: From Redox Homeostasis to Therapeutic Targeting.

🥈 Top 2% JournalArticle

4 days ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

A Small Molecule That Detects Damaged Mitochondria and Selectively Boosts Their Removal by AutophagyA Damage-Gated Small-Molecule Chimera Selectively Enhances Mitophagy by Coupling Dysfunctional Mitochondria to Autophagy.

🥈 Top 2% JournalArticle

4 days ago • Aging cell

A New Peptide Activates SIRT1 by Targeting Its Interaction with USP25 to Reduce Cell AgingA Novel Peptide Targeting the USP25-SIRT1 Interaction Activates SIRT1 to Suppress Cell Senescence.

🥉 Top 5% JournalArticle

3 days ago • GeroScience

Irregular daily light cycles affect health but not lifespan in male miceChronic non-24-h light-dark cycles alter healthspan measures but not overall survival in male C57BL/6 J mice.

🎖️ Top 10% JournalArticle

2 days ago • Journal of advanced research

Ziyu glycoside I may reduce aging and improve age-related decline by stabilizing an enzyme and restoring lactate productionZiyu glycoside I suppresses senescence and ameliorates age-related functional decline by stabilizing LDHA and restoring lactate output.

🥉 Top 5% JournalArticle

yesterday • Herz

Can Age Be Changed to Lower Heart Disease Risk?Age: a modifiable risk factor for cardiovascular disease?

📖 Top 50% JournalArticle

5 days ago • GeroScience

Measuring natural ability and aspirin's impact in older men and women: analysis from a clinical trialValidation of an intrinsic capacity index and the effects of aspirin in older males and females: secondary analysis of a randomized controlled trial.

🎖️ Top 10% JournalArticle

5 days ago • Molecular neurobiology

Mitochondrial Problems Linked to α-Synuclein Toxicity in Lab Models of Protein ClumpsMitochondrial Dysfunction as a Convergent Mechanism of α-Synuclein Toxicity: A Systematic Review of In Vitro Fibrillar Models.

🎖️ Top 10% JournalSystematic Review

yesterday • Cell

Fatty acid changes influence whether cells become old or die from iron-related damageFatty acid desaturation controls cellular fate decisions between senescence and ferroptosis.

🏆 Top 0.1% JournalArticle

4 days ago • Journal of cell science

🎖️ Top 10% JournalArticle

4 days ago • Food science & nutrition

Nicotinamide Mononucleotide's Protective Effect on Fatty Liver Disease Caused by High-Fat Diet in MiceHepatoprotective Effect of Nicotinamide Mononucleotide on High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice.

📖 Top 20% JournalArticle

3 days ago • Geriatric nursing (New York, N.Y.)

Understanding Long Life in Nursing: A Framework to Improve Healthy YearsConceptualizing longevity in nursing: a multidimensional framework for healthspan optimization.

📖 Top 20% JournalArticle

3 days ago • GeroScience

Sesaminol reduces alcohol-related aging in the colon of middle-aged mice, possibly through protective cell pathwaysSesaminol attenuates alcohol-induced colonic senescence in middle-aged mice: potential involvement of the AhR-Nrf2 axis.

🎖️ Top 10% JournalArticle

6 days ago • Aging cell

Aging Support Cells May Cause Stem Cell Aging by Producing Imbalanced Signaling MoleculesSenescent Mesenchymal Stromal Cells Drive Stem Cell Aging Through Dysregulated Chemokine Synthesis.

🥉 Top 5% JournalArticle

6 days ago • Autophagy

Overview of the human protein maintenance system: the cell’s recycling pathwaySurvey of the human proteostasis network: the autophagy-lysosome pathway.

🥈 Top 2% JournalArticle

5 days ago • Neuro-oncology

Standard treatment for childhood BRAF-V600E brain tumors causes cell aging and makes tumors more sensitive to BCL-xL blockingStandard treatment against paediatric BRAF-V600E glioma promotes senescence and sensitizes tumours to BCL-xL inhibition.

🥇 Top 1% JournalArticle

5 days ago • Biogerontology

A task-focused approach to evaluating molecular clocks that estimate biological agingBeyond age prediction: a task-oriented framework for evaluating molecular aging clocks.

📖 Top 20% JournalArticle

4 days ago • Translational neurodegeneration

Disordered proteins linked to problems with cell recycling acidity in brain diseasesThe pathological roles of intrinsically disordered proteins in lysosomal acidification dysfunction in neurodegenerative diseases.

🥈 Top 2% JournalArticle

1 week ago • GeroScience

Interaction between Sonic Hedgehog and Matrix Metalloproteinases in Brain Blood Vessel Aging and Stroke: A Possible MechanismSonic hedgehog-matrix metalloproteinase crosstalk in neurovascular ageing and stroke: a potential mechanistic link.

🎖️ Top 10% JournalArticle

3 days ago • Journal of orthopaedic translation

Changing immune cells in joint and muscle diseases: from local tissue roles to treatment possibilitiesMacrophage reprogramming in degenerative musculoskeletal diseases: From tissue-niche biology to therapeutic translation.

🎖️ Top 10% JournalArticle

5 days ago • Cell

Calorie restriction changes mutation rate independently of lifespanCalorie restriction uncouples mutation rate from lifespan.

🏆 Top 0.1% JournalComment

5 days ago • Autophagy

Overview of the human protein quality control system: the ubiquitin-proteasome pathwaySurvey of the human proteostasis network: the ubiquitin-proteasome system.

🥈 Top 2% JournalArticle

4 days ago • Journal of Alzheimer's disease : JAD

Levels of p62 protein in spinal fluid linked to tau buildup, brain changes, and thinking problems in adults without dementiaCerebrospinal fluid p62/SQSTM1 is associated with tau pathology, brain structural alterations, and cognitive impairment in adults without dementia.

📖 Top 20% JournalArticle

4 days ago • Science advances

LAMP2A gene therapy reduces Parkinson's disease symptoms in primatesLAMP2A gene therapy mitigates Parkinson's disease-related pathology in nonhuman primates.

🥈 Top 2% JournalArticle