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1 week ago • JCI insight

Muscle growth and endurance after eating are controlled by feeding-activated mTORC1 signaling, but muscle size is not affectedFeeding-induced muscle mTORC1 signaling regulates postprandial protein synthesis and endurance but not muscle size.

🥉 Top 5% JournalArticle

1 week ago • Scientific reports

Combined analysis of genes and molecules shows disrupted fats and metabolism and timing changes during disease progressionIntegrative multi-omics analysis reveals lipid/metabolite dysregulation and temporal decoupling in disease progression.

📖 Top 20% JournalArticle

1 week ago • Cell death and differentiation

Immune cell receptors CXCR3 and CXCR5 influence nerve cell self-cleaning processCanonical lymphocyte chemokine receptors CXCR3 and CXCR5 modulate neuronal autophagy.

🥇 Top 1% JournalArticle

1 week ago • MedComm

Combined Analysis Shows That Aβ42-Me3 Clumps Block Mitochondrial Cleanup in Early Alzheimer's DiseaseMulti-Omics Analysis Reveals That Aβ42- Me3 Co-Aggregation Induces Mitophagy Blockade in Early Stages of Alzheimer's Disease.

🥉 Top 5% JournalArticle

1 week ago • PLoS genetics

A protein complex in fission yeast helps lengthen chromosome ends and prevent their rearrangementFission yeast RPA-TERT-Tpz1TPP1 complex promotes telomere extension and suppresses telomere recombination.

🥉 Top 5% JournalArticle

1 week ago • HemaSphere

Mitochondrial DNA mutations linked to weaker energy production and better imatinib response in chronic myeloid leukemiaMitochondrial DNA mutations are associated with impaired oxidative phosphorylation and enhanced imatinib response in chronic myeloid leukemia.

🎖️ Top 10% JournalArticle

1 week ago • JCI insight

SMURF2 reduces the cell’s ability to clear tuberculosis bacteria in immune cellsSMURF2 inhibits autophagic control of Mycobacterium tuberculosis in macrophages.

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1 week ago • Autophagy

Increasing amino acid levels inside cells reduces problems in cells lacking autophagyAugmenting intracellular amino acid pools suppresses the phenotypes of autophagy-deficient cells.

🥈 Top 2% JournalArticle

1 week ago • PloS one

Using artificial intelligence to find and understand combined anti-aging compounds in Dengzhan Shengmai formulaArtificial intelligence-driven identification and mechanistic exploration of synergistic anti-aging compounds from Dengzhan Shengmai formulation.

📖 Top 30% JournalArticle

1 week ago • Nature biotechnology

Using protein-based aging measures in a phase 2a clinical trial to support testing of anti-aging treatmentsIntegration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment.

🏆 Top 0.1% JournalArticle

1 week ago • Translational psychiatry

Health Habits and Cell Aging in Severe Mental IllnessHealth behaviours and telomere biology in severe mental disorders.

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1 week ago • Aging cell

Blocking Growth Hormone Receptors May Extend LifespanGrowth Hormone Receptor Antagonism Extends Lifespan.

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1 week ago • Aging cell

How Changes in Telomere DNA Packaging Influence Telomere MaintenanceTwisting the End Game: How Telomere Chromatin Modifications Shape Telomere Maintenance.

🥉 Top 5% JournalArticle

1 week ago • Traffic (Copenhagen, Denmark)

Tau Protein Clumps in Lysosomes Disrupt Cell Cleanup in Neurodegeneration"S-Tau-Lled" Lysosomes Disrupt Autophagic Processes in Neurodegeneration.

📖 Top 20% JournalArticle

2 weeks ago • Gut microbes

How Nutrition Affects Communication Between the Gut and Brain Immune System Throughout LifeNutritional regulation of gut-brain immune crosstalk across the lifespan.

🥈 Top 2% JournalArticle

2 weeks ago • Rheumatology (Oxford, England)

🎖️ Top 10% JournalArticle

2 weeks ago • The Journal of dermatology

Local Low-Frequency Vibration May Improve Wound Healing and Reduce Cell Aging in High Blood Sugar RatsLocal Low-Frequency Vibration Enhances Wound-Healing and Modulates Cellular Senescence in Tissues and Exudates in a Hyperglycemic Rat Model.

📖 Top 20% JournalArticle

2 weeks ago • CNS neuroscience & therapeutics

Melatonin may improve thinking and reduce harmful cell cleanup in rats with blood flow-related dementiaMelatonin Improves Cognitive Function and Suppresses Excessive Mitophagy in Rats With Vascular Dementia.

🎖️ Top 10% JournalArticle

2 weeks ago • Autophagy

RAB1 helps OPTN control damaged mitochondria removal by bringing in ATG9ARAB1 mediates OPTN-dependent mitophagy via ATG9A recruitment.

🥈 Top 2% JournalArticle

2 weeks ago • The EPMA journal

Changes in biological aging over time and their link to heart disease and stroke riskDynamic reversibility of biological aging and risk of cardiovascular disease and stroke: a longitudinal cohort study.

🎖️ Top 10% JournalArticle

2 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

How Phase Separation and Material Properties Affect the Behavior of Cellular Cleaning Structures in MammalsPhase Separation, Material State, and Condensate Fate in Mammalian Autophagy.

🥈 Top 2% JournalArticle

2 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Nanoparticles Targeting Mitochondria Reduce Inflammation Caused by Damaged Mitochondrial DNAMitochondria-Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA-Driven Inflammation at the Source.

🥈 Top 2% JournalArticle

2 weeks ago • Orthopaedic surgery

Osteoarthritis Treatments: Progress from Understanding Joint Environment to Using RegenerationOsteoarthritis Therapeutics: From Microenvironment Understanding to Regenerative Intervention-Current Advances and Future Perspectives.

📖 Top 30% JournalArticle

2 weeks ago • Molecular biomedicine

Glutamine Transport by SLC1A5 Controls Macrophage Aging and Cleanup Function During Liver RepairSolute Carrier Family 1 Member 5 (SLC1A5)-dependent glutamine transport regulates macrophage senescence and efferocytosis during liver regeneration.

🥉 Top 5% JournalArticle

2 weeks ago • The Journal of clinical investigation

How the brain’s process for clearing damaged cell parts affects neuron health and nerve diseasesMitophagy in neuronal health and disease: from mechanisms to neurodegeneration.

🥈 Top 2% JournalArticle

2 weeks ago • Lupus science & medicine

Changes in MLKL crotonylation linked to RAB1A-mTOR signaling and cell recycling in kidney tubule cells in lupus nephritisCrotonylome profiling identifies MLKL crotonylation in lupus nephritis associated with RAB1A-mTOR signalling and autophagy changes in tubular epithelial cells.

🎖️ Top 10% JournalArticle

2 weeks ago • Nature aging

Aging patterns vary across human tissues and show coordinated declineMapping structural aging across human tissues reveals tissue-specific trajectories and coordinated deterioration.

🥇 Top 1% JournalArticle

2 weeks ago • Advances in pharmacological and pharmaceutical sciences

How PCSK9 Influences Inflammation in Fat-Building Cells and Natural Compounds That May Affect This ProcessPCSK9-Mediated Inflammation in Foam Cell Formation and Exploring the Biologically Active Compounds Derived From Natural Resources.

📖 Top 30% JournalArticle

2 weeks ago • Aging cell

SIRT1 May Turn Off L1 Mobile DNA by Supporting Chromatin-Stabilizing ComplexesSIRT1 Silences L1 Retrotransposons by Stabilizing Heterochromatin-Modifying Complexes.

🥉 Top 5% JournalArticle

3 weeks ago • MedComm

How the Body Uses Amino Acids in Health and IllnessAmino Acid Metabolism in Health and Disease.

🥉 Top 5% JournalArticle

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