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3 days ago • GeroScience

Irregular daily light cycles affect health but not lifespan in male miceChronic non-24-h light-dark cycles alter healthspan measures but not overall survival in male C57BL/6 J mice.

🎖️ Top 10% JournalArticle

4 days ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

A Small Molecule That Detects Damaged Mitochondria and Selectively Boosts Their Removal by AutophagyA Damage-Gated Small-Molecule Chimera Selectively Enhances Mitophagy by Coupling Dysfunctional Mitochondria to Autophagy.

🥈 Top 2% JournalArticle

4 days ago • Food science & nutrition

Nicotinamide Mononucleotide's Protective Effect on Fatty Liver Disease Caused by High-Fat Diet in MiceHepatoprotective Effect of Nicotinamide Mononucleotide on High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice.

📖 Top 20% JournalArticle

4 days ago • Translational neurodegeneration

Disordered proteins linked to problems with cell recycling acidity in brain diseasesThe pathological roles of intrinsically disordered proteins in lysosomal acidification dysfunction in neurodegenerative diseases.

🥈 Top 2% JournalArticle

4 days ago • Aging cell

A New Peptide Activates SIRT1 by Targeting Its Interaction with USP25 to Reduce Cell AgingA Novel Peptide Targeting the USP25-SIRT1 Interaction Activates SIRT1 to Suppress Cell Senescence.

🥉 Top 5% JournalArticle

5 days ago • Neuro-oncology

Standard treatment for childhood BRAF-V600E brain tumors causes cell aging and makes tumors more sensitive to BCL-xL blockingStandard treatment against paediatric BRAF-V600E glioma promotes senescence and sensitizes tumours to BCL-xL inhibition.

🥇 Top 1% JournalArticle

5 days ago • GeroScience

Measuring natural ability and aspirin's impact in older men and women: analysis from a clinical trialValidation of an intrinsic capacity index and the effects of aspirin in older males and females: secondary analysis of a randomized controlled trial.

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5 days ago • Autophagy

Overview of the human protein quality control system: the ubiquitin-proteasome pathwaySurvey of the human proteostasis network: the ubiquitin-proteasome system.

🥈 Top 2% JournalArticle

5 days ago • Ecology and evolution

Molecular Changes and Sex Differences in Gene Control During Multi-Year Dormancy of the Cabbage BeetleMolecular Adaptations and Sex-Biased Regulatory Pathways in Multi-Year Diapause of the Cabbage Beetle Colaphellus bowringi: A Duration-Resolved Transcriptomic Analysis.

📖 Top 20% JournalArticle

5 days ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

A Fat Cell Signaling Pathway Helps Keep Insulin Working in Mice and Changes in Human ObesityAn Adipocyte MKK3-p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity.

🥈 Top 2% JournalArticle

6 days ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Serine Metabolism Controlled by PHGDH in Spine Disc Cells May Be a Treatment Target for Disc DegenerationPHGDH-Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration.

🥈 Top 2% JournalArticle

6 days ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

DUSP26 Controlled by YY1 Lactylation Links Bone Formation and Blood Vessel Growth by Activating Cell Cleaning in Bone Stem CellsDUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs.

🥈 Top 2% JournalArticle

6 days ago • Aging cell

Aging Support Cells May Cause Stem Cell Aging by Producing Imbalanced Signaling MoleculesSenescent Mesenchymal Stromal Cells Drive Stem Cell Aging Through Dysregulated Chemokine Synthesis.

🥉 Top 5% JournalArticle

6 days ago • Autophagy

Overview of the human protein maintenance system: the cell’s recycling pathwaySurvey of the human proteostasis network: the autophagy-lysosome pathway.

🥈 Top 2% JournalArticle

1 week ago • Autophagy

Overview of the human protein maintenance system: making, folding, and organelle-specific processesSurvey of the human proteostasis network: translation, protein folding, and organelle-specific systems.

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1 week ago • GeroScience

Interaction between Sonic Hedgehog and Matrix Metalloproteinases in Brain Blood Vessel Aging and Stroke: A Possible MechanismSonic hedgehog-matrix metalloproteinase crosstalk in neurovascular ageing and stroke: a potential mechanistic link.

🎖️ Top 10% JournalArticle

1 week ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

A Nanoparticle System Inspired by Nature Boosts Cell Cleaning and Recovery After Spinal Cord InjuryA Biomimetic PLK1 Nanodelivery System Promotes Migrasome-Mediated Mitocytosis to Restore Efferocytosis and Functional Recovery After Spinal Cord Injury.

🥈 Top 2% JournalArticle

1 week ago • Aging cell

Changes in Gene Packaging Linked to Aging, Brain Inflammation, and Metabolism in Alzheimer's DiseaseHistone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease.

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1 week ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Aging donor cells shift damaged mitochondria from recycling to small vesicle release using a protein-stabilizing processDonor-Cell Senescence Redirects PINK1-Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3-Stabilized HSPA9.

🥈 Top 2% JournalArticle

1 week ago • Human mutation

Potential Biomarkers Linked to Mitochondrial Cleanup in AtherosclerosisCCR5, CD163, CSF1R, and FCGR3A as Candidate Biomarkers Associated With Mitophagy in Atherosclerosis.

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1 week ago • MedComm

Blocking Leptin Reduces Age-Related Inflammation in Blood Vessel and Immune CellsLeptin Neutralization Attenuates Inflammaging in Endothelial and Immune Cell Models.

🥉 Top 5% JournalArticle

1 week ago • Aging cell

Partial Cell Reprogramming with Yamanaka Factors May Reduce Stroke Damage in Older MiceIn Vivo Partial Cell Reprogramming With Yamanaka Factors Reduced Ischemic Brain Damage in Aging Mice.

🥉 Top 5% JournalArticle

1 week ago • JCI insight

The cell recycling receptor TEX264 helps skin cells mature and is disrupted in Darier diseaseThe endoplasmic reticulum autophagy receptor TEX264 drives epidermal differentiation and is dysregulated in Darier disease.

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1 week ago • Molecular biomedicine

How sirtuin proteins work and their potential for treatmentsThe sirtuin family: from mechanisms to therapy.

🥉 Top 5% JournalArticle

1 week ago • Annals of neurology

Faster Biological Aging in Frontotemporal Dementia Linked to Smoking, Inflammation, and MetabolismAccelerated Epigenetic Aging in Frontotemporal Dementia Highlights Smoking, Inflammation, and Metabolic Signals.

🥈 Top 2% JournalArticle

1 week ago • Clinical and translational medicine

A lysosomal protein helps protect the heart from injury after blood flow returns by promoting removal of damaged mitochondria through the NEDD4-LC3 pathwayLysosomal protein transmembrane 5 protects against myocardial ischemia-reperfusion injury by promoting mitophagy via the NEDD4-LC3 axis.

🥉 Top 5% JournalArticle

1 week ago • Aging cell

A Cilia-Based NAD+ Signaling System Controls Lysosome Balance in the Hypothalamus and Metabolic AgingA Cilia-Centered Nicotinamide Adenine Dinucleotide (NAD+) Signaling Network Regulates Hypothalamic Lysosomal Homeostasis and Metabolic Aging.

🥉 Top 5% JournalArticle

1 week ago • Molecular biomedicine

Using lipid nanoparticles to deliver a gene activator’s instructions for treating fatty liver disease linked to metabolism problemsLipid nanoparticle-mediated transcription factor EB mRNA delivery for the treatment of metabolic dysfunction-associated steatotic liver disease.

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2 weeks ago • Frontiers in molecular biosciences

Communication between fat storage and energy systems in osteoarthritis linking fat use to energy imbalanceLipid droplet-mitochondria crosstalk in osteoarthritis: linking lipid routing to metabolic mismatch.

📖 Top 20% JournalArticle

2 weeks ago • GeroScience

Metformin's effects on blood gene activity in older adults with age-related vision lossAn exploratory study of the effect of metformin on the whole blood transcriptome of nondiabetic older adults with age-related macular degeneration.

🎖️ Top 10% JournalArticle

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Longevity & Aging Research Papers