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1 week ago • Frontiers in immunology

🥉 Top 5% JournalArticle

1 week ago • International journal of molecular sciences

Hedgehog Signaling Controls Low-Oxygen Metabolic Changes in Myeloid Leukemia CellsHedgehog Signaling Regulates Hypoxia-Associated Metabolic Adaptation in Myeloid Leukemia In Vitro Cell Models.

📖 Top 20% JournalArticle

1 week ago • Nutrients

NAD Metabolism in Acute Myeloid Leukemia: Biological Basis and Treatment PossibilitiesNAD Metabolism in Acute Myeloid Leukaemia: Biological Rationale and Therapeutic Opportunities.

🎖️ Top 10% JournalArticle

1 week ago • Frontiers in immunology

How the Immune System Controls Normal Body FunctionsThe immune system as a regulator of normal physiology.

🥉 Top 5% JournalArticle

1 week ago • International journal of molecular sciences

Exercise changes liver cell energy production through muscle, gut, and thyroid system interactions in fatty liver diseaseExercise-Induced Hepatic Mitochondrial Reprogramming Across Muscle-Gut-Thyroid Axes in MASLD/MASH.

📖 Top 20% JournalArticle

1 week ago • Biomedicines

Mitochondrial Problems: From How They Happen to New Research Methods for Lab and Medical StudiesMitochondrial Dysfunction: From Molecular Mechanisms to Modern Approaches for Basic and Clinical Research.

📖 Top 20% JournalArticle

1 week ago • International journal of molecular sciences

Oxyresveratrol reduces growth signals and survival while increasing cell death in normal EGFR lung cancer cells stimulated by EGFOxyresveratrol Suppresses EGF-Induced AKT Phosphorylation and Reduces Cellular Fitness While Promoting Apoptosis in EGFR-Wild-Type Non-Small Cell Lung Cancer Cells Under EGF Stimulation.

📖 Top 20% JournalArticle

1 week ago • Antioxidants (Basel, Switzerland)

Disulfiram may reduce fatty liver inflammation in mice by blocking Aurora Kinase A and restoring cell cleanupDisulfiram Alleviates Metabolic Dysfunction-Associated Steatohepatitis in Mice via Inhibiting Aurora Kinase A and Restoring Autophagy.

🎖️ Top 10% JournalArticle

1 week ago • Antioxidants (Basel, Switzerland)

FoxO’s role in metabolism problems linked to oxidative stress, cell death, Wnt signaling, and gut bacteriaChasing the FoxO in Metabolic Disorders: Novel Considerations for Oxidative Stress, Programmed Cell Death, Wnt, and the Gut Microbiome.

🎖️ Top 10% JournalArticle

1 week ago • International journal of molecular sciences

How Cell Cleanup and Inflammation Control May Shift Ongoing Inflammation to Blood Vessel Changes in Kawasaki Disease Resistant to IVIG TreatmentThe Autophagy-Inflammasome Axis as a Molecular Switch: From Persistent Inflammation to Vascular Remodeling in IVIG-Resistant Kawasaki Disease.

📖 Top 20% JournalArticle

1 week ago • International journal of molecular sciences

Genetic and Molecular Factors in Non-Ischemic Heart Failure with Normal Pumping Function: How Pathways Interact, Regional Differences, and Treatment ImplicationsGenetic and Molecular Mechanisms of Non-Ischemic Heart Failure with Preserved Ejection Fraction: Pathway Crosstalk, Translational Implications, and Regional Genetic Context.

📖 Top 20% JournalArticle

1 week ago • International journal of molecular sciences

How Infections May Trigger Cell Aging Through Host and Microbe InteractionsHost-Pathogen Interaction as a Driver of Cellular Senescence: Microbial Triggers and Host Response.

📖 Top 20% JournalArticle

1 week ago • Molecules (Basel, Switzerland)

Effects of a Micelle-Based Resveratrol Formula on Brain Growth Support and Nerve Signaling in Healthy RatsEvaluation of the Impact of Micellar Formulation of Resveratrol on Neurotrophic Factors and Neuromodulatory Potential in Healthy Rats.

📖 Top 20% JournalArticle

1 week ago • eLife

Cell imaging shows type I and type II kinase inhibitors differently affect LRRK2 filament formation and their binding to cell movement structuresIn-cell cryo-electron tomography reveals differential effects of type I and type II kinase inhibitors on LRRK2 filament formation and microtubule association.

🥈 Top 2% JournalArticle

1 week ago • iMeta

Hyperoside may reduce aging of uterine lining cells in unexplained recurrent miscarriage by helping resolve DNA-RNA structures through DHX9Hyperoside alleviates endometrial stromal cell senescence in unexplained recurrent spontaneous abortion via DHX9-mediated R-loop resolution.

🥇 Top 1% JournalArticle

1 week ago • Journal of cardiovascular development and disease

Blood Vessel Lining Mitochondria Problems in INOCA and Small Heart Vessel Dysfunction: Causes, Differences Between Men and Women, and Treatment PossibilitiesEndothelial Mitochondrial Dysfunction in INOCA and Coronary Microvascular Dysfunction: Mechanisms, Sex Differences, and Therapeutic Implications.

📖 Top 30% JournalArticle

1 week ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Movement of Bacteroides Uniformis from Gut to Liver May Reduce Severe Fatty Liver Disease by Stopping Liver Cell Damage Through Propionic AcidGut-Liver Translocation of Bacteroides Uniformis Alleviates Advanced Metabolic Dysfunction-Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion.

🥈 Top 2% JournalArticle

1 week ago • Protein & cell

Gene editing screen finds GNPTAB activates a cell defense pathway that causes cell agingCRISPR screening identifies GNPTAB as a noncanonical STING activator driving cellular senescence.

🥇 Top 1% JournalArticle

1 week ago • Food science & nutrition

Health Benefits and How Urolithin A Works: From Gut Bacteria Product to Medical UsesHealth Benefits and Molecular Mechanisms of Urolithin A: From a Gut Microbiota-Derived Metabolite to Translational Applications.

📖 Top 20% Journal

1 week ago • Aging cell

How AcSirt2 and FOXO Control Mitochondrial Cleanup to Help Slow Aging in Asian Honey BeesUnveiling the AcSirt2-FOXO-Mitophagy Axis: Insights Into Mitochondrial Quality Control and Delayed Aging in Apis cerana.

🥉 Top 5% Journal

1 week ago • Autophagy

IL17A may disrupt cell waste recycling and lysosome renewal through a specific signaling pathway in Huntington diseaseIL17A disrupts autophagy-lysosomal function and lysosome reformation through the GSK3B-TFE3 signaling pathway in Huntington disease.

🥈 Top 2% Journal

1 week ago • npj aging

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1 week ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

A Blood Protein May Help ALS by Triggering Cell Cleanup to Remove Harmful Protein Clumps Without Using the Usual PathwayA Blood-Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN-Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1.

🥈 Top 2% Journal

1 week ago • Nature communications

Short-term rapamycin treatment shows different ways inflammation during pregnancy causes problems in miceAcute rapamycin treatment reveals distinct mechanisms of dysfunction in a maternal inflammation mouse model.

🥈 Top 2% Journal

1 week ago • MedComm

Biological Roles and Treatment Potential of SIRT ProteinsSIRT Family: Biological Functions and Therapeutic Targets.

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1 week ago • Biogerontology

Cell Aging and Chronic Inflammation: How They Work and Possible TreatmentsCellular senescence and inflammageing: from mechanisms to senotherapeutic interventions.

📖 Top 20% Journal

2 weeks ago • Life medicine

SIRT1 reduces lactate production by modifying PKM2 to help prevent early ovarian failureSIRT1 deacetylates PKM2 to constrain lactate production and protect against premature ovarian insufficiency.

🎖️ Top 10% Journal

2 weeks ago • Stem cell research & therapy

Miro1 helps stem cell treatment for muscle loss by restoring healthy mitochondriaMiro1-mediated mitochondrial transfer boosts stem cell therapy for muscle atrophy via restoring mitochondrial homeostasis.

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2 weeks ago • Aging cell

Platelet-Coated Resveratrol Nanoparticles May Improve Mitochondrial Problems and Aging in Blood Vessel Cells During Atherosclerosis by Activating FOXM1Mechanistic Study of Platelet Membrane-Coated Resveratrol Nanosystem in Mitochondrial Dysfunction and Endothelial Senescence During Atherosclerotic Lesion Development via FOXM1 Activation.

🥉 Top 5% Journal

2 weeks ago • JCI insight

Gut bacteria products influence helper T-cell development and immune aging in HIV-1 infectionMicrobiome-Derived Metabolites Shape CD4⁺ T-Cell Differentiation and Immune Aging in HIV-1 Infection.

🥉 Top 5% Journal

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