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3 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

How a Fat-Processing Enzyme Links RNA Modification to Breakdown of Spinal Disc TissueACSL4-Dependent Lysosomal Lipid Peroxidation Links WTAP-Mediated m6A Modification to Intervertebral Disc Degeneration.

🥈 Top 2% JournalArticle

3 weeks ago • Aging cell

TPP1 Protein Supports Hair Growth by Activating Hair Follicle Stem CellsShelterin TPP1 Promotes Hair Regeneration Through Activating Bulge Hair Follicle Stem Cells.

🥉 Top 5% JournalArticle

3 weeks ago • Aging cell

Anti-Aging Approaches Based on Body Metabolism, Cell Aging Treatments, and Stem Cell TherapiesA Mechanism-Based Framework for Anti-Aging Strategies: From Metabolic Regulation to Senotherapy and Stem Cell-Based Interventions.

🥉 Top 5% JournalArticle

3 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Lower KLF5 May Connect Reduced Mitochondrial Cleanup to Inflammation and Valve Changes in Calcific Aortic Valve DiseaseKLF5 Downregulation Links Impaired BNIP3-Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease.

🥈 Top 2% JournalArticle

3 weeks ago • Pharmaceuticals (Basel, Switzerland)

Safety and Action of a Natural Injectable Treatment Targeting Skin Aging PathwaysMechanistic and Preliminary Safety Profiling of a Multicomponent Natural Product-Based Injectable Formulation Targeting Skin Aging-Related Pathways: A Network Pharmacology and Single-Dose Toxicity Study.

📖 Top 20% JournalArticle

3 weeks ago • Antioxidants (Basel, Switzerland)

Lutein reduces fat build-up by activating cell cleanup processes in liver cells with fat accumulationLutein Attenuates Lipid Accumulation in Association with TFEB Nuclear Translocation and Autophagy-Lysosomal Responses in a Cellular Model of Hepatic Steatosis.

🎖️ Top 10% JournalArticle

3 weeks ago • Antioxidants (Basel, Switzerland)

Calcium Entry into Mitochondria May Cause Energy Defects in Muscle Lacking PDR-1/Parkin in C. elegansMitochondrial Ca2+ Influx via MCU-1 Contributes to Oxidative Mitochondrial Defects in PDR-1/Parkin-Deficient Caenorhabditis elegans Body-Wall Muscle.

🎖️ Top 10% JournalArticle

3 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

The RNA-Binding Protein RBMS1 Helps Blood Vessel Lining Cells Clean Themselves to Keep Vessels Healthy and Prevent Deep Vein Blood ClotsAn RNA-Binding Protein RBMS1 Promotes Endothelial Cell Autophagy to Maintain Vascular Homeostasis and Suppress Deep Vein Thrombosis.

🥈 Top 2% JournalArticle

3 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Reduced Cell Cleanup Speed Up Spine Disc Wear by Causing MIDN Build-Up That Breaks Down TSC2 ProteinImpaired Chaperone-Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation.

🥈 Top 2% JournalArticle

3 weeks ago • FEBS letters

Translophagy: A possible connection between cell recycling problems and protein-making errorsTranslophagy-A potential link between autophagy impairment and translational errors.

📖 Top 20% JournalArticle

3 weeks ago • International journal of molecular sciences

Repeated Pressure Reduces Cell Recycling and Activity in Human Osteoarthritis Cartilage CellsRepetitive Compressive Loading Downregulates the Expression of Autophagy-Related Factors, Autophagy Capacity and Cellular Activity in Human Osteoarthritic Chondrocytes.

📖 Top 20% JournalArticle

3 weeks ago • International journal of molecular sciences

📖 Top 20% JournalArticle

3 weeks ago • MedComm

Mitochondria as the Central Control of Cell Self-Destruction and Their Interactions with Other Cell PartsMitochondria as the Hub of Apoptosis: A Comprehensive Insight From Mitochondria to Interactions With Other Organelles.

🥉 Top 5% JournalArticle

3 weeks ago • Nature communications

RTEL1 gene changes affect dyskeratosis congenita caused by telomerase RNA mutationsRTEL1 mutation modifies dyskeratosis congenita caused by a telomerase RNA template mutation.

🥈 Top 2% JournalArticle

3 weeks ago • Protein & cell

LMNA R527C mutation may cause a premature aging syndrome with inflammation by activating DNA detection pathwaysLMNA R527C pathogenic variant causes an inflammation-driven segmental progeroid syndrome via triggering DNA-sensing pathways.

🥇 Top 1% JournalArticle

3 weeks ago • The EMBO journal

Losing Erbin in kidney tubule cells makes mice more vulnerable to sudden kidney damage and worsens scarringLoss of Erbin in tubular epithelial cells sensitizes mice to acute kidney injury and aggravates renal fibrosis.

🥇 Top 1% JournalArticle

3 weeks ago • Autophagy

A signaling network linked to cell structure growth connects extra centrosomes with cell cleaning processesConnecting the dots: a centrosome-associated RAC1 signaling network links centrosome amplification with autophagy.

🥈 Top 2% JournalArticle

4 weeks ago • Current obesity reports

🥉 Top 5% JournalArticle

4 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

How USP30 Prevents Cell Clean-Up to Cause Kidney Tube Damage in DiabetesUSP30-Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease.

🥈 Top 2% JournalArticle

4 weeks ago • Autophagy

Loss of BECN1 changes what B cells target and how they present antigens without stopping autophagosome formationLoss of BECN1 does not compromise autophagosome formation but alters cargo selection and HLA-restricted antigen presentation of B cells.

🥈 Top 2% JournalArticle

4 weeks ago • Aging cell

LivAge: An Online Tool to Estimate Mouse Age from Gene ActivityLivAge: An Online Aging Clock for Murine Transcriptomic Age Estimation.

🥉 Top 5% JournalArticle

4 weeks ago • Autophagy

Handling Cell Membrane Stress Using CASMDealing with membrane stress through CASM.

🥈 Top 2% JournalArticle

4 weeks ago • Aging cell

hTERT Immortalization Keeps Human Umbilical Cord Stem Cells Stable and Preserves Their Small Vesicles’ Ability to Regulate Immunity and Activate Early Egg FollicleshTERT Immortalization Stabilizes Human Umbilical Cord MSCs and Maintains Their Small Extracellular Vesicles With Preserved Immunomodulatory Activity and Primordial Follicle-Activating Capacity.

🥉 Top 5% JournalArticle

1 month ago • Advanced healthcare materials

Nanoparticle Treatments Targeting Cell Energy Centers in Age-Related Brain Diseases: New Possibilities and Clinical PromiseMitochondria-Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential.

🥉 Top 5% JournalArticle

1 month ago • mSystems

Age-adjusted machine learning finds facial skin microbes linked to skin quality in Korean womenAge-adjusted machine learning identifies facial skin microbes associated with skin quality among Korean women.

🎖️ Top 10% JournalArticle

1 month ago • Journal of the American Chemical Society

Newly Created Dual-Function Proteins for Targeted Protein BreakdownDe Novo-Designed Bifunctional Proteins for Targeted Protein Degradation.

🥇 Top 1% JournalArticle

1 month ago • Journal of endocrinological investigation

Lifelong untreated growth hormone deficiency does not change white blood cell telomere lengthLifelong congenital untreated isolated GH deficiency does not alter human leukocyte telomere length.

📖 Top 20% JournalArticle

1 month ago • Experimental & molecular medicine

Aging of blood-forming stem cells: gene activity and molecular changes with possible AI applicationsHematopoietic stem cell aging: a review of transcriptional and multi-omics insights and potential paths for AI integration.

🥈 Top 2% JournalArticle

1 month ago • Cell proliferation

Macrophage Fat Balance May Contribute to Spinal Disc Degeneration by Reducing Clearance of Aging CellsMacrophage Lipid Homeostasis Drives IVDD via a Senescence-Dependent Impairment of Efferocytosis.

🥉 Top 5% JournalArticle

1 month ago • Molecular neurobiology

Astrocyte Problems in Parkinson's Disease Linked to Reduced Cell Protection and Increased Cell Damage, Offering Targets for TreatmentDual-Pathway Astrocyte Failure in Parkinson's Disease: Therapeutic Targeting of Nrf2/TFEB Suppression and cGAS-STING/Ferroptosis Activation.

🎖️ Top 10% JournalArticle

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Longevity & Aging Research Papers