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2 weeks ago • eLife

Human brain organoid shows immune cell recruitment by microglia and immune problems linked to Alzheimer's diseaseAn integrated human forebrain organoid reveals microglia-mediated CD8+ T cell recruitment and neuroimmune dysfunction in Alzheimer's disease pathology.

🥈 Top 2% JournalArticle

2 weeks ago • Translational neurodegeneration

Exercise may reduce brain immune cell activity to boost fat breakdown and improve thinking in Alzheimer's diseaseExercise promotes lipophagy and mitigates cognitive impairment in Alzheimer's disease through downregulating microglial TMEM9.

🥈 Top 2% JournalArticle

2 weeks ago • Frontiers in endocrinology

Immune Cells and Metabolism Changes Linked to Reduced Ovarian Reserve: Disease Features and Possible TreatmentsMacrophages and immunometabolism in diminished ovarian reserve: pathological features and therapeutic implications.

🎖️ Top 10% JournalArticle

2 weeks ago • eLife

Bruce reduces self-cleaning enzyme activity and wing growth in fruit fliesBruce suppresses autophagy-regulated caspase activity and wing tissue growth in Drosophila.

🥈 Top 2% JournalArticle

2 weeks ago • Frontiers in cellular neuroscience

Immune Cells in the Ear and Their Role in Age-Related Hearing Loss: Inflammation and Potential TreatmentsThe cochlear macrophage in presbycusis: inflammaging, neuroinflammation, and targets for therapeutic modulation.

🎖️ Top 10% JournalArticle

2 weeks ago • Frontiers in pharmacology

Natural products affecting mitochondrial balance through movement, recycling, drug behavior, and safetyNatural products targeting mitochondrial homeostasis: a four-dimensional framework integrating dynamics, mitophagy, pharmacokinetics, and translational safety.

📖 Top 20% JournalArticle

2 weeks ago • Frontiers in cell and developmental biology

How Angelica Pubescens-Taxillus Chinensis compounds may help relieve spine disc damage caused by pressure through the piezo1/NF-κB signaling pathwayMechanistic study on components of Angelica Pubescens-Taxillus Chinensis in improving compression-induced intervertebral disc degeneration via piezo1/NF-κB signaling axis.

🎖️ Top 10% JournalArticle

2 weeks ago • Frontiers in immunology

Immune and inflammation links to cell death and heart scarring genes in heart failure with preserved pumpingImmune and inflammatory features associated with pyroptosis- and myocardial fibrosis-related genes in HFpEF: a machine learning study.

🥉 Top 5% JournalArticle

2 weeks ago • Frontiers in nutrition

How intermittent fasting may affect metabolism through gut bacteria, body clocks, and cell cleanupChrononutritional regulation of metabolic homeostasis: intermittent fasting through gut microbiota, circadian rhythms, and autophagy.

📖 Top 20% JournalArticle

2 weeks ago • International journal of molecular sciences

Piceatannol selectively kills chemotherapy-induced senescent colon cancer cells by disrupting their energy and triggering cell deathCorrection: Ambrosino et al. Selective Senolysis of 5FU-Induced CRC Senescent Cells by Piceatannol Through Mitochondrial Depolarization and AIF-Dependent Apoptosis. Int. J. Mol. Sci. 2025, 26, 9134.

📖 Top 20% JournalPublished Erratum

2 weeks ago • Bone research

Stress response systems help cartilage cells adapt and survive in Metaphyseal Chondrodysplasia Type SchmidIntegrated stress signaling pathways promote adaptive reprogramming for chondrocyte survival in Metaphyseal Chondrodysplasia Type Schmid.

🥈 Top 2% JournalArticle

2 weeks ago • International journal of molecular sciences

Biological Effects of 3-Hydroxypyridine Compounds Combined with Natural IngredientsBiological Activity of 3-Hydroxypyridine Derivatives with Natural Components.

📖 Top 20% JournalArticle

2 weeks ago • Animals : an open access journal from MDPI

Effects of Pollen Substitute Diets on Honey Bees’ Gene Activity, Immune Health, and SurvivalIntegrated Assessment of Pollen Substitute Diets in Honey Bees Based on Transcriptional Responses, Immune-Derived Predicted Biological Age, and Survival.

📖 Top 30% JournalArticle

2 weeks ago • Experimental & molecular medicine

Small particles from platelets may cause aging in CD8+ T cells in chronic kidney disease by transferring microRNA-550a-5pPlatelet-derived microparticles induce CD8+ T cell senescence in chronic kidney disease via the transfer of microRNA-550a-5p.

🥈 Top 2% JournalArticle

2 weeks ago • Aging cell

MTR4: A Key Protein Supporting Healthy Blood Vessel Lining in Young TissueMTR4: A Conserved Youth Factor for Vascular Endothelium.

🥉 Top 5% JournalArticle

2 weeks ago • Molecules (Basel, Switzerland)

New Treatments Targeting Sirtuins for Healthy Thinking in Aging and Possible Benefits for Alzheimer's DiseaseTargeting Specific Sirtuin Modulation: Emerging Therapeutic Strategies for Healthy Cognitive Ageing and Potential Implications for Alzheimer's Disease.

📖 Top 20% JournalArticle

2 weeks ago • International journal of molecular sciences

Mapping ULK1 Protein Modifications to Show Linked Control of Cell Cleanup and Energy UseIntegrative Phosphoproteomic Characterization of ULK1 Phosphosites Reveals Co-Regulatory Networks in Autophagy and Metabolic Adaptation.

📖 Top 20% JournalArticle

2 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Mitochondrial Maintenance in Muscle and Bone Diseases: Key Signals and Treatment OptionsMitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes.

🥈 Top 2% JournalArticle

2 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Bone Marrow Immune Cell Signaling Connects Fat Growth in Bone Marrow to Energy Loss and Bone Formation Decline in AgingBone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging.

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2 weeks ago • Evolutionary applications

Epigenetic Clocks Can Estimate Age in Largemouth Bass Despite Differences in Location and SexEpigenetic Clocks Can Predict Age in the Largemouth Bass-Complex Despite Spatial and Sexual Variation.

🎖️ Top 10% JournalArticle

2 weeks ago • MedComm

MicroRNA-708 Activated by AMPK May Slow Cell Aging by Reducing Disabled-2 and mTORC1 ActivityCorrection to "AMPK-upregulated microRNA-708 Plays as a Suppressor of Cellular Senescence and Aging via Downregulating Disabled-2 and mTORC1 Activation".

🥉 Top 5% JournalPublished Erratum

3 weeks ago • Biochemical Society transactions

How Fasting and Diet May Increase Cell Cleaning: Separating Truth from MythsIncreasing autophagy with fasting and diet: separating fact from fiction.

🎖️ Top 10% JournalArticle

3 weeks ago • Leukemia

Blocking a specific cell cleanup process may improve venetoclax treatment in acute myeloid leukemiaInhibition of PHB2/PINK1-mediated mitophagy potentiates venetoclax activity in acute myeloid leukemia.

🥈 Top 2% JournalArticle

3 weeks ago • Glia

Autophagy in Schwann Cells May Protect Nerve Insulation in a Mouse Model of Krabbe DiseaseSchwann Cell-Specific ATG7-Dependent Autophagy Protects Myelin in a Mouse Model of Krabbe Disease.

🥉 Top 5% JournalArticle

3 weeks ago • Renal failure

Faster Biological Aging Linked to Progression of Heart, Kidney, and Metabolic Problems in UK and US PopulationsBiological age acceleration and cardiovascular-kidney-metabolic syndrome progression: evidence from UK Biobank and NHANES.

📖 Top 30% JournalArticle

3 weeks ago • Journal of inherited metabolic disease

Inherited Metabolic Diseases and the Role of Selective Cell RecyclingRevisiting Inherited Metabolic Diseases (IMDs) Through the Lens of Selective Autophagy.

📖 Top 20% JournalArticle

3 weeks ago • Molecular biomedicine

Protein recycling and balance in the ear's hearing system and its link to hearing lossThe ubiquitin-proteasome system and proteostasis in the cochlea and sensorineural hearing disorders.

🥉 Top 5% JournalArticle

3 weeks ago • Exploration (Beijing, China)

Bazi Bushen Formula may reverse chronic stress-related aging and inflammation by activating energy and cell maintenance pathways and renewing immune cellsReversal of Chronic Stress-Induced Inflammaging by Bazi Bushen Formula Through AMPK-Sirtuins Axis Activation and Myeloid Reset.

🥈 Top 2% JournalArticle

3 weeks ago • GeroScience

Mitochondria problems and chronic inflammation: a link between energy failure and aging cellsMitochondrial dysfunction and inflammaging: a mechanistic bridge between bioenergetic failure and senescence.

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3 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Bacteria-Produced 1-Allylpiperazine May Reduce Parkinson’s Symptoms by Boosting Cellular CleanupBacteria-Derived 1-Allylpiperazine Alleviates Symptoms of Parkinson's Disease Model by Promoting Autophagy.

🥈 Top 2% JournalArticle

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Longevity & Aging Research Papers