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3 weeks ago • Journal of Huntington's disease

Ways to Help Break Down Mutant Huntingtin Protein and Potential TreatmentsDirecting mutant huntingtin towards degradation: Strategies and therapeutic opportunities.

🎖️ Top 10% JournalArticle

3 weeks ago • PLoS biology

The protein RBBP5 controls gene regulation that affects protein balance in cellsThe histone methyltransferase complex subunit RBBP5 serves as a central epigenetic regulator of proteostasis dynamics.

🥉 Top 5% JournalArticle

3 weeks ago • PLoS genetics

Stable DNA packaging protects mitochondrial balance and limits TORC1 cell signalingChromatin stability safeguards mitochondrial homeostasis and restrains TORC1 signaling.

🥉 Top 5% JournalArticle

3 weeks ago • GeroScience

Brain health score linked to eye structure and metabolism in UK Biobank dataBrain care score and retinal health: structural and metabolic insights from the UK Biobank.

🎖️ Top 10% JournalArticle

3 weeks ago • Journal of Parkinson's disease

Overview of immune cells in the blood of people with Parkinson’s diseaseProfiling peripheral immune cells in Parkinson's disease: A scoping review.

🎖️ Top 10% JournalArticle

3 weeks ago • PLoS genetics

Lack of ZBED6 causes harmful heart enlargement by disrupting cell cleaning through the MEOX1-ERK1/2 pathwayZBED6 deficiency drives pathological cardiac hypertrophy through MEOX1-ERK1/2-dependent autophagy dysfunction.

🥉 Top 5% JournalArticle

3 weeks ago • Drug delivery

New niosome method for effective gene delivery in aging umbilical cord stem cellsInnovative niosome screening for efficient gene delivery in senescent primary umbilical cord stroma-derived MSCs.

🎖️ Top 10% JournalArticle

3 weeks ago • Neurochemical research

Repeated Sleep Loss with Aging May Cause Early Memory Problems, Brain Inflammation, and Blood-Brain Barrier Issues in Female RatsRecurrent Sleep Restriction During Aging Induces Early Recognition Memory Impairment, Neuroinflammation, and Blood-Brain Barrier Dysfunction in Female Wistar Rats.

📖 Top 20% JournalArticle

3 weeks ago • GeroScience

How Calorie Restriction Changes Aging-Related Damage and Protein Repair in the Brain and BodyAgainst the "extend healthspan but not lifespan" cliché.

🎖️ Top 10% JournalArticle

3 weeks ago • Experimental & molecular medicine

Macrophage cell death may cause aging and cell changes in prostate growth treated with 5α-reductase inhibitorsMacrophage pyroptosis drives luminal senescence and club-cell reprogramming in 5α-reductase inhibitor-treated prostatic hyperplasia.

🥈 Top 2% JournalArticle

3 weeks ago • Brain pathology (Zurich, Switzerland)

Muscle control differences in infant and adult Pompe patients revealed by combined molecular and structural analysisIdentifying regulatory muscle processes in infantile and adult Pompe patients using a multi-omic and morphological approach.

🥉 Top 5% JournalArticle

4 weeks ago • PLoS medicine

An AI-based aging score linked to risk and death prediction in heart, kidney, and metabolic conditionsA machine learning-derived aging index for risk stratification and mortality prediction in cardiovascular-kidney-metabolic syndrome: A retrospective cohort study.

🥈 Top 2% JournalArticle

4 weeks ago • The Journal of clinical investigation

Movement of USP15 between the cell nucleus and cytoplasm promotes harmful cell recycling that disrupts neural stem cell balance and brain developmentNucleocytoplasmic shuttling of USP15 promotes pathological autophagy that disrupts neural stem cell homeostasis and neurodevelopment.

🥈 Top 2% JournalArticle

4 weeks ago • Aging cell

New Flavonoid Drugs That Target Aging Cells May Reduce Aging Signs and Improve HealthNovel Flavonoid Senotherapeutics Identified by Phenotypic Drug Discovery Reduce Senescence and Improve Multiple Markers of Healthspan.

🥉 Top 5% JournalArticle

1 month ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Senolytic Drugs Activated Only by Both Light and Enzymes for Targeted TherapyOrthogonal Light- and Enzyme-Triggered and-Gate Prodrugs for Senolytic Therapy.

🥈 Top 2% JournalArticle

yesterday • Cell biochemistry and function

Resveratrol may affect bone health by blocking inflammation through the SIRT1 pathway: molecular details and treatment possibilitiesResveratrol Modulates Bone Metabolism Through SIRT1-Mediated NF-κB Inhibition: Molecular Mechanisms and Therapeutic Implications.

📖 Top 30% JournalArticle

4 days ago • Journal of cell science

🎖️ Top 10% JournalArticle

5 days ago • Neural regeneration research

How the Sirtuin 1/PGC-1α Pathway Controls Mitochondria and May Help Treat Neurodegenerative DiseasesSirtuin 1/peroxisome proliferator-activated receptor gamma coactivator 1α signaling pathway: Molecular mechanisms from mitochondrial function regulation to the treatment of neurodegenerative diseases.

📖 Top 20% JournalArticle

5 days ago • Neural regeneration research

Changes in nerve cell receptors in the aging bone lining: From detailed cell maps to repair targetsNeuronal receptor remodeling in the aging periosteum: From single-cell atlases to regenerative targets.

📖 Top 20% JournalArticle

1 week ago • Neural regeneration research

Rapamycin helps injured nerves recover by affecting the communication between the brain, body, and musclesTargeting the central-peripheral-effector muscle axis: Rapamycin promotes functional recovery in injured peripheral nerves.

📖 Top 20% JournalArticle

1 week ago • Basic and clinical andrology

How energy cell damage and inflammation may contribute to infertility caused by varicoceleThe role of the mitochondrial injury-mediated oxidative stress-sterile inflammation axis in varicocele-induced infertility: a narrative review.

📖 Top 30% JournalArticle

1 week ago • Cardiorenal medicine

The apelin signaling system as an additional target alongside RAAS blockers in heart and kidney diseaseThe apelin/APJ system as a complementary target to RAAS blockade in cardiorenal disease.

📖 Top 30% JournalArticle

2 weeks ago • Molecular biology reports

Changing cell cleaning processes to improve skin wound healing: studying molecular steps for new treatmentsRewiring autophagy to target cutaneous wound healing: investigation of molecular mechanisms to therapeutic interventions.

📖 Top 30% JournalArticle

6 days ago • Chimia

How mTOR and Small Cell Particles Connect Chemical Stress to Communication Between OrganismsmTOR and Extracellular Vesicles: Linking Chemical Stress to Ecological Communication.

Article

3 weeks ago • Open medicine (Warsaw, Poland)

Stem cells with extra ATG5 help ligament healing by promoting healing-type immune cells in older ratsATG5-overexpressing MSCs improve ligament healing with an associated shift toward M2 macrophage polarization in aged rats.

📖 Top 50% JournalArticle

1 week ago • Plastic and reconstructive surgery. Global open

Fast Wound Healing Linked to Taking NAD+ Supplements by Mouth: A Case StudyRapid Wound Healing Observed Following Oral LathMized NAD+ Supplementation: A Case Study.

📖 Top 30% JournalCase Reports

yesterday • Autophagy

The role of cell-cleaning processes in oxidative stress and autoimmune thyroid inflammationMitophagy at the crossroads of oxidative stress and autoimmune thyroiditis.

🥈 Top 2% JournalArticle

yesterday • Cell

Fatty acid changes influence whether cells become old or die from iron-related damageFatty acid desaturation controls cellular fate decisions between senescence and ferroptosis.

🏆 Top 0.1% JournalArticle

yesterday • Ageing research reviews

The Role of the Thioredoxin System in Cell Aging and Its Potential as a Treatment TargetThe Thioredoxin System in Cellular Senescence and Ageing: From Redox Homeostasis to Therapeutic Targeting.

🥈 Top 2% JournalArticle

yesterday • Advanced healthcare materials

Nanobody-Modified Outer Membrane Vesicles May Reduce Alzheimer’s-Like Brain Cell Damage by Changing Mitochondrial Cleanup and Inflammatory SignalsNanobody-Modified Outer Membrane Vesicles Attenuate Alzheimer's Disease-Like Neurodegeneration by Modulating Mitophagy-Associated Phenotypes and cGAS-STING-Related Inflammatory Signaling.

🥉 Top 5% JournalArticle

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Longevity & Aging Research Papers