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1 week ago • Signal transduction and targeted therapy

Disulfidptosis: how it works at the molecular level and possible treatment targetsDisulfidptosis: molecular mechanisms and therapeutic targets.

🥇 Top 1% JournalResearch Support, Non-U.S. Gov't

4 days ago • Health science reports

How Different Biological Age Estimates May Predict Outcomes in Breast Cancer PatientsPrognostic Value of Different Biological Age Estimation Methods in Breast Cancer Patients: A Population-Based Cohort Study Using NHANES 1999-2020.

📖 Top 50% JournalArticle

4 days ago • Journal of human hypertension

Cardiovascular frailty as a new type of frailtyCardiovascular frailty - an emerging frailty phenotype.

📖 Top 20% JournalArticle

2 weeks ago • The journal of gene medicine

Lysosome Problems Linked to Spinal Disc Wear: Molecular Types and Key Genes Found Using Advanced AnalysisLysosomal Dysfunction Is Associated With Intervertebral Disc Degeneration: Multiomics and Machine Learning Identify Molecular Subtypes and Hub Genes.

📖 Top 30% JournalArticle

2 weeks ago • Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences

Trehalose's overlooked roles in Alzheimer's: gut, brain, and cell cleanup signals beyond common targetsTrehalose's untapped mechanisms in alzheimer's: gut-brain-autophagy signalling beyond the usual targets.

📖 Top 30% JournalArticle

3 weeks ago • Metabolites

The role of an enzyme and energy molecule balance in protecting brain cells and agingNicotinamide Mononucleotide Adenylyltransferase 1 and NAD+ Homeostasis in Neuroprotection and Aging.

📖 Top 20% JournalArticle

3 weeks ago • Open life sciences

How SIRT1 helps protect blood vessels from aging caused by stressProtective effect and mechanism of SIRT1 under stress-induced vascular senescence.

📖 Top 50% JournalArticle

1 week ago • Aging medicine (Milton (N.S.W))

Understanding How Biological Aging Works to Help Medical ResearchInsights Into the Mechanisms of Biological Aging That Guide Translational and Clinical Research.

📖 Top 30% JournalEditorial

2 weeks ago • Medicine

Faster biological aging linked to death risk in U.S. adults with heart, kidney, and metabolic problems at early to moderate stagesBiological age acceleration and mortality risk among U.S. adults with cardio-kidney-metabolic syndrome, stages 0-3: An NHANES cohort study.

📖 Top 50% JournalArticle

yesterday • Journal of drug targeting

Aging Skin Cells Release Particles That Affect Skin Aging and Repair, Offering Potential Treatment OptionsSenescence-Associated Extracellular Vesicles in Skin Aging and Regeneration: From Pathophysiology to Therapeutic Opportunities.

📖 Top 20% JournalArticle

yesterday • Journal of molecular medicine (Berlin, Germany)

How early cell aging, inflammation, and cell energy communication relate to CBD’s heart-protective effects in heart failure with preserved pumping functionProspective associations of premature senescence, inflammation, and MERCSs in the cardioprotective effect of CBD in HFpEF.

🎖️ Top 10% JournalArticle

yesterday • Journal of molecular neuroscience : MN

Genetic and Molecular Links Between Oxidative Stress and Brain Degeneration: From Gene Control to Disease ProcessesMulti-omics Insights into Oxidative Stress-related Genes and Neurodegenerative Diseases: From Epigenetic Regulation to Pathogenic Pathways.

📖 Top 20% JournalArticle

yesterday • Ecotoxicology and environmental safety

T-2 toxin may cause cartilage cell damage by affecting energy production controlled by SIRT1 and PGC-1αSIRT1/PGC-1α-regulated mitochondrial biogenesis is involved in T-2 toxin-induced chondrocyte injury.

🎖️ Top 10% JournalArticle

2 days ago • Genes & diseases

Lactylation's role in metabolism, gene control, and cell death in heart tissue damage after blood flow returnsLactylation: Metabolic epigenetic regulation and cell death mechanisms in myocardial ischemia‒reperfusion injury.

🎖️ Top 10% JournalArticle

3 days ago • Pharmacological research

Aging of muscle-supporting cells through specific protein changes slows muscle healing after steroid injuryCellular senescence of fibro-adipogenic progenitors by STAT5A/GFPT2/O-GlcNAcylation impairs muscle recovery after glucocorticoid-induced injury.

🥉 Top 5% JournalArticle

3 days ago • Molecular biomedicine

Betaine helps protect the liver by boosting cell cleanup and antioxidant defenses through chemical changesBetaine-driven Keap1 methylation promotes p62-mediated autophagy and Nrf2 stabilization to alleviate glutathione-dependent redox dyshomeostasis in liver injury.

🥉 Top 5% JournalArticle

3 days ago • Journal of photochemistry and photobiology. B, Biology

MDL800, a SIRT6 activator, may reduce UV-related skin aging by lowering oxidative stress, DNA damage, and collagen lossMDL800, an allosteric SIRT6 activator, ameliorates UV-induced skin photoaging by attenuating oxidative stress, DNA damage, and collagen degradation.

📖 Top 30% JournalArticle

3 days ago • Autophagy

How the AMBRA1-RMC1-HUWE1 system controls tagging of mitochondria in specific cell areasSpatial control of mitochondrial ubiquitination by the AMBRA1-RMC1-HUWE1 axis.

🥈 Top 2% JournalArticle

3 days ago • Pharmacological research

Changes in HMGB1 location over time affect organelle interactions and guide precise drug targeting in diabetic blood vessel diseaseSpatiotemporal redistribution of HMGB1 shapes organelle interactome dysfunction and informs precision pharmacological targeting in diabetic vascular disease.

🥉 Top 5% JournalArticle

3 days ago • Science advances

A blood vessel cell pathway linked to blood vessel decline and overall agingEndothelial C/EBPβ/AEP pathway drives vascular deterioration and systemic aging.

🥈 Top 2% JournalArticle

3 days ago • Free radical biology & medicine

β-Amyloid and Glutathione Imbalance Together Cause Fat Damage and Cell Death in Neuron-Like Cellsβ-Amyloid and glutathione dysregulation cooperatively drive lipid peroxidation and ferroptosis in neuron-like cells.

🥉 Top 5% JournalArticle

3 days ago • GeroScience

Blood levels of NAD+ linked to frailty in older adults living in the communityAssociation between whole-blood NAD+ concentration and frailty in community-dwelling older adults: the Itabashi Longitudinal Study on Aging.

🎖️ Top 10% JournalArticle

3 days ago • Reproductive sciences (Thousand Oaks, Calif.)

Autophagy's two roles in uterine scarring and how it relates to age-related fertility problemsDual Roles of Autophagy in Endometrial Fibrosis and Its Implications in Age-Related Reproductive Dysfunction.

📖 Top 20% JournalArticle

4 days ago • Oral diseases

How Mouth Bacteria and Aging-Related Inflammation May Affect Gum Disease and Overall Health in Older AdultsThe Oral Microbiome-Inflammaging Axis in Elderly Periodontitis: Emerging Immunopathogenic and Systemic Mechanisms.

📖 Top 20% JournalArticle

4 days ago • JID innovations : skin science from molecules to population health

📖 Top 20% JournalArticle

4 days ago • Obesity surgery

Weight Loss Surgery and Changes in the Heart-Based Biological Age Difference Over TimeMetabolic and Bariatric Surgery and Change in the AI-ECG-Derived Biological-Age Gap: A Longitudinal Cohort Study.

📖 Top 20% JournalArticle

4 days ago • Bioactive materials

How tiny cell particles can harm or help joint damage in osteoarthritis depending on the situationFrom pathogenic to reparative: Context-Dependent function of extracellular vesicles in osteoarthritis.

🥈 Top 2% JournalArticle

4 days ago • Journal of feline medicine and surgery

Behavior, senses, and environment strategies to help cats age healthilyEXPRESS: Beyond the bowl: behavioural, sensory and environmental strategies to support healthy ageing in cats.

📖 Top 30% JournalArticle

4 days ago • Research (Washington, D.C.)

Using Rapamycin-Releasing Nanofibers to Improve Lymphatic and Immune Response for Brain Covering Repair and Protection After Traumatic Brain Injury in RatsLymphatic-Immune Microenvironment Engineering via Rapamycin-Eluting Nanofibers for Meningeal Repair and Neuroprotection in Traumatic Brain Injury Rats.

🥉 Top 5% JournalArticle

4 days ago • European journal of human genetics : EJHG

Genetic and computer analysis of changes in telomere control genes in people with bone marrow failureGenomic and computational analysis of variants in telomere regulatory genes in subjects with bone marrow failure.

🎖️ Top 10% JournalArticle

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Longevity & Aging Research Papers