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2 weeks ago • Aging cell

Lower Levels of a Cell Cleanup Regulator and Faulty Cell Recycling Linked to Older Kidneys' Vulnerability to Infection-Related InjuryDown-Regulation of TFEB With Defective Autophagy in the Susceptibility of Aging Kidneys to Septic Acute Kidney Injury.

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2 weeks ago • Reproductive biology and endocrinology : RB&E

Theca cells as key players in ovarian agingTheca cells: active orchestrators of ovarian aging.

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2 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Gut bacteria release ferulic acid from sprouted quinoa to reduce obesity-linked thinking problems by boosting waste removal in memory areas of the brainGut Microbial Release of Ferulic Acid From Germinated Quinoa Alleviates Obesity-Associated Cognitive Impairment by Activating Hippocampal Mitophagy Associated with PINK1/Parkin Pathway.

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2 weeks ago • Cellular and molecular neurobiology

Monomethyl Fumarate's effects on iron use and energy production in brain immune cells linked to multiple sclerosis progressionMonomethyl Fumarate Modulates Iron Metabolism and Mitochondrial Function in Microglia with Implications for Multiple Sclerosis Progression.

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2 weeks ago • The EMBO journal

Atg23 stops incorrect merging of Atg9 transport vesicles when delivering materials to autophagosome formation sitesAtg23 prevents aberrant fusion of Atg9 vesicles during delivery to autophagosome formation sites.

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2 weeks ago • npj aging

Intermittent chloroquine treatment extends lifespan, prevents breast tissue overgrowth, and lowers harmful blood fats and growth protein levels in female ratsIntermittent chloroquine treatment extends lifespan and prevents mammary hyperplasia in female rats while reducing serum ldl and igfbp3 levels.

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2 weeks ago • Cell death & disease

LARS controls aging and self-cleaning processes in liver cancer cellsLARS regulates cellular senescence and autophagy in liver cancer cells.

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2 weeks ago • Molecular neurodegeneration

Human stem cell–derived brain immune cells improve brain damage and circuit problems in mice lacking progranulinTransplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice.

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2 weeks ago • Biology direct

Reducing ATP6V1A increases skin cell aging caused by UVB lightV-ATPase-targeted siRNA library screening reveals ATP6V1A negatively regulates UVB-induced keratinocyte senescence.

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3 weeks ago • Cell death discovery

Piceatannol as a safe treatment to reduce aging signs in mice after radiationPiceatannol as a safe senotherapeutic: ameliorating senescence-associated markers in a radiation-induced murine model.

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3 weeks ago • Cell proliferation

Integrin Beta-1 helps stabilize cell structure to reduce stress-induced cell death and disc degeneration by supporting mitochondrial cleanupItgb1-Mediated Stabilization of Vimentin Alleviates Excessive Mechanical Stress-Induced Nucleus Pulposus Cell Pyroptosis and Intervertebral Disc Degeneration via PINK1-Parkin-Dependent Mitophagy.

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3 weeks ago • The FEBS journal

Fighting Aging by Maintaining Protein Balance Outside CellsCombating ageing beyond the cell: Emerging roles of extracellular proteostasis.

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3 weeks ago • Cellular and molecular life sciences : CMLS

How aging and cell aging relate through shared molecular processesCellular senescence and aging: molecular mechanisms and convergent pathways.

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3 weeks ago • Journal of cachexia, sarcopenia and muscle

A Redox-Sensitive Role of Dnajb5 in Antarctic Fish Muscle Repair Involving mTORC1 and HDAC4Dnajb5 From Antarctic Fish Reveals a Redox-Sensitive Mechanism Coordinating Muscle Regeneration via mTORC1 and HDAC4.

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3 weeks ago • Cell death & disease

Acid ceramidase changes fat molecules and increases vulnerability to ferroptosis in aging WI-38 cellsAcid ceramidase modulates the lipid profile and exacerbates sensitivity to ferroptosis in WI-38 replicative senescent cells.

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3 weeks ago • Journal of medicinal chemistry

New synthetic molecules targeting cell aging in age-related lung scarringDiscovery of Novel Synthetic Cyclohexene-Based Small Molecules Targeting Senescence against Age-Related Pulmonary Fibrosis.

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3 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Kaempferol May Reduce Knee Cartilage Damage in Spaceflight by Protecting Mitochondrial Health Through NOX4Kaempferol Attenuates Spaceflight-Associated Knee Cartilage Degradation by Targeting NOX4-Mediated Mitochondrial Dysfunction.

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3 weeks ago • Chinese medicine

New progress in electroacupuncture for memory and thinking problems around surgery: how it works and clinical proofAdvances in electroacupuncture for perioperative neurocognitive disorders: mechanisms and clinical evidence.

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3 weeks ago • PloS one

How problems in cell cleanup relate to nerve damage in diabetes, focusing on signaling and fat metabolismMolecular mechanisms of autophagy disorder in diabetic neuropathy: Focusing on signaling pathways and regulation of lipid metabolism.

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3 weeks ago • Scientific reports

Using genes to measure aging and improve care in gilthead sea bream farmingDecoding biological aging in Sparus aurata through a gene toolbox to infer welfare assessment and precision aquaculture interventions.

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3 weeks ago • Life science alliance

Blocking CDK4/6 causes cells to release aging-related signals by slowing activation of NF-κBCDK4/6 inhibition induces a senescence-associated secretory phenotype via delayed NF-κB activation.

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4 weeks ago • Apoptosis : an international journal on programmed cell death

Mitochondria problems and cell aging may speed up pregnancy aging in early natural birthsMitochondrial dysfunction and cellular senescence drive accelerated gestational aging in spontaneous preterm birth: a narrative review.

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4 weeks ago • JCI insight

Small blood vessel self-cleaning and cell death processes are key regulators of kidney scarring after blood flow injuryMicrovascular autophagy and caspase-3 activation are central regulators of renal fibrosis after ischemia-reperfusion.

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4 weeks ago • The EMBO journal

Local problems with cell cleanup cause widespread changes in nerve endings and increase brain resilienceLocal autophagy impairment triggers brain-wide presynaptic remodeling and resilience.

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4 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Breathable nanospray that responds to oxidative stress may help lung immune cells recover and reduce lung damage from radiationInhalable ROS-Responsive Nanospray Activates PPAR-γ to Restore Macrophage Mitochondrial Homeostasis and Attenuate Radiation-Induced Lung Injury.

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4 weeks ago • Pediatric research

Using both cannabinoids and nicotine during pregnancy may increase aging in developing human lungsCo-exposure to cannabinoids and nicotine increases senescence in prenatal human lung development.

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4 weeks ago • Clinical epigenetics

A DNA-based aging clock linked to death risk as a possible marker for frailtyExploring a targeted epigenetic clock based on mortality-associated CpGs as a potential biomarker for frailty.

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1 month ago • PLoS pathogens

Staphylococcus aureus changes arginine use to promote mammary gland aging through immune and tissue cell interactionStaphylococcus aureus rewires arginine metabolism to drive mammary aging via macrophage-epithelial crosstalk.

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1 month ago • The EMBO journal

SenFlag gene pattern identifies aging cells in mouse and human tissues through shared gene activitySenFlag gene signature identifies senescent cells in mouse and human tissues through a conserved core transcriptional program.

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1 month ago • Molecular biomedicine

Lack of Sirtuin 1 links long-term kidney disease inflammation to heart and blood vessel hardeningSirtuin 1 deficiency mediates chronic kidney disease-induced inflammaging cardiovascular calcification.

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Longevity & Aging Research Papers