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4 days ago • Acta ophthalmologica

Faster biological aging is linked to a higher buildup of large drusenAccelerated biological ageing is associated with a large drusen burden.

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4 days ago • The Journal of arthroplasty

Faster Biological Aging Predicts Lower Function and Higher Surgery Risk in Knee ReplacementBiological Age Acceleration Predicts Functional Decline and Surgical Risk in Knee Arthroplasty.

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4 days ago • ACS biomaterials science & engineering

Complex Control Systems of Cell Aging: From How It Works to Diagnosis and TreatmentMultidimensional Regulatory Network of Cellular Senescence: From Mechanisms to Theranostics.

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4 days ago • iScience

The conflicting roles of DsbA-L in protecting against and contributing to stress responsesThe DsbA-L paradox in protective and pathogenic stress adaptation.

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5 days ago • Journal of hazardous materials

Bisphenol A changes brown fat by causing cell death, fat buildup, and inflammationBisphenol A remodels brown adipose tissue via apoptosis, whitening, and inflammatory stress.

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5 days ago • Seminars in nephrology

Kidney Injury Molecule: A Marker and Its Other RolesKidney Injury Molecule: a Biomarker and much more.

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5 days ago • Signal transduction and targeted therapy

Hepassocin may slow liver aging and help liver repair by activating energy controlHepassocin prevents age-related liver senescence and facilitates liver regeneration by activating AMPK.

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5 days ago • Materials today. Bio

Relieving nerve pain by using tiny particles that deliver working mitochondria and a mitochondria-cleanup booster to reshape cell energy centersMitochondrial remodeling by extracellular vesicles co-delivering functional mitochondria and a mitophagy inducer for neuropathic pain relief.

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5 days ago • Materials today. Bio

A cell membrane-covered DNA nanoplatform for reshaping cartilage and joint lining interaction in osteoarthritisA biomimetic chondrocyte membrane-camouflaged tFNA nanoplatform for reprogramming the cartilage-synovium axis in osteoarthritis.

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5 days ago • Acta biochimica et biophysica Sinica

piR-45962 increases self-destructive cell death in aged heart injury by affecting a specific cell signaling pathwaypiR-45962 exacerbates autophagic apoptosis in aged myocardial ischemia-reperfusion injury through modulation of the HNRNPH1/GATA5 signaling axis.

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5 days ago • Pharmacological research

NMN May Reduce Liver Damage Caused by LPS by Preventing Cell Death Through Blocking the cGAS-STING-ACSL4 PathwayNMN Mitigates LPS-Induced Liver Injury by Inhibiting Ferroptosis via Suppression of the cGAS-STING-ACSL4 Axis.

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6 days ago • Zoological research

Low oxygen before birth causes egg cell damage from oxidative stress through the Sirt3/Sod2 pathway, which may be reduced by nicotinamide mononucleotideFetal hypoxia causes oocyte oxidative stress damage via the Sirt3/Sod2 pathway and can be alleviated by nicotinamide mononucleotide.

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1 week ago • Materials today. Bio

Nanoparticles with D-mannose for skin aging treatment by protecting a key anti-aging proteinDevelopment of nanoparticles loaded with D-mannose for topical treatment to alleviate skin aging via rescuing SIRT1 from degradation.

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1 week ago • Chemico-biological interactions

Neuroglobin helps control cell cleanup and prevent cell damage in brain development harmed by sevoflurane by boosting YTHDF3Neuroglobin positively regulates YTHDF3 to restore mitophagy and suppress ferroptosis in sevoflurane-induced developmental neurotoxicity.

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1 week ago • Materials today. Bio

Nano-sized carriers with high Salvianolic acid B improve osteoarthritis treatment by targeting damaged cell partsThe mitophagy targeted nano-assemblies with high Salvianolic acid B -loading sufficiently enhances osteoarthritis therapy.

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1 week ago • Archives of biochemistry and biophysics

Blocking ITIH3 reduces cell stress and self-cleaning processes in kidney cells by controlling the HSP90B1/STAT3 pathway, helping to ease diabetic kidney damageTargeting ITIH3 inhibits oxidative stress and autophagy in renal tubular epithelial cells by regulating the HSP90B1/STAT3 axis, thereby alleviating diabetic nephropathy injury.

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1 week ago • Pharmacological research

Balance of Cell Energy Centers in Muscle and Bone Diseases: Causes and Targeted TreatmentsMitochondrial homeostasis in musculoskeletal diseases: From pathogenic mechanisms to precision therapies.

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1 week ago • Molecular neurobiology

Fructooligosaccharides improve gut function and boost brain fatty acids to reduce nerve cell death caused by mitochondrial recycling in rats with long-term reduced brain blood flowFructooligosaccharides Restore Gut Function and Increase Hippocampal Short-Chain Fatty Acids to Alleviate Neuronal Apoptosis Induced by Mitochondrial Autophagy in rats with Chronic Cerebral Hypoperfusion.

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1 week ago • Calcified tissue international

PAI-1's role in bone breakdown and repair may depend on different conditionsSERPINE1/PAI-1 in Skeletal Degeneration: A Proposed Context-Dependent Framework for Bone Remodeling Regulation.

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1 week ago • Journal of diabetes investigation

Protein Balance in Controlling Pancreatic Islet Cell FlexibilityProteostasis in the regulation of pancreatic islet cell plasticity.

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1 week ago • Food & function

Comparison of weight-loss effects of popular natural products in animal studies using data analysisComparative anti-obesity efficacy of high-interest natural products in preclinical models: a bibliometric and network meta-analysis.

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1 week ago • Molecular therapy : the journal of the American Society of Gene Therapy

D-Amino Acid Prodrug DLMEH May Activate Cell Growth Pathway Through Sestrin2 to Improve Muscle Protein Production in Age-Related Muscle LossD-Amino Acid Prodrug DLMEH Activates mTORC1 via Sestrin2 to Restore Muscle Protein Synthesis in Sarcopenia.

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1 week ago • Acta neuropathologica

Molecular processes in the brain's arousal center connect APOE and pigment buildup to Alzheimer's riskMolecular programs in human locus coeruleus link APOE and neuromelanin to Alzheimer's vulnerability.

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1 week ago • International journal of pharmaceutics: X

Using tiny immune-targeting particles to change joint inflammation and help repair cartilage in osteoarthritisNanoimmunomodulation for cartilage repair in osteoarthritis: reprogramming the inflammatory joint microenvironment.

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1 week ago • Trends in pharmacological sciences

Proteins that remove tags controlling the cleanup of damaged mitochondria for therapyDeubiquitinases in mitophagy: therapeutic control of mitochondrial quality.

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1 week ago • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Rapamycin may increase brain blood flow and change metabolism, inflammation, and gut bacteria in healthy middle-aged people with APOE4EXPRESS: Rapamycin increases cerebral blood flow and modulates metabolic, inflammatory, and microbiome profiles in healthy middle-aged APOE4 carriers: a pilot single-arm trial.

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1 week ago • European journal of pharmacology

Cycloastragenol may lengthen lifespan and boost stress resistance in worms by reducing insulin signaling and activating immune defense through p38 MAPKCycloastragenol extends lifespan and enhances stress resistance in Caenorhabditis elegans by inhibiting IIS pathway and activating p38 MAPK-mediated innate immunity.

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1 week ago • Nature reviews. Nephrology

How the kidney heals or worsens after sudden injuryMechanisms of regeneration and maladaptive repair in acute kidney injury.

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1 week ago • Journal of photochemistry and photobiology. B, Biology

Pomegranate peel extract in bilophytosome form protects skin from UVB aging by reducing inflammation, cell damage, aging signs, and tissue breakdownPomegranate peel extract bilophytosome protects against UVB- induced skin photoaging through pleiotropic modulation of inflammation, mitophagy, senescence, and metalloproteinases.

📖 Top 30% JournalArticle

1 week ago • Biology of reproduction

Problems in Galectin-1 Signaling May Disrupt Tissue Aging and Preparation for Pregnancy in Repeated Implantation FailureGalectin-1 Signaling Dysregulation Impairs Stromal Senescence and Decidualization in Recurrent Implantation Failure.

📖 Top 20% JournalArticle

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Longevity & Aging Research Papers