OpenScience.ink

2 days ago • Journal of Alzheimer's disease : JAD

Dry, but not wet, age-related macular degeneration is linked to higher Alzheimer's disease riskDry, but not wet, age-related macular degeneration increases Alzheimer's disease risk: Findings from a multidimensional analysis.

📖 Top 20% JournalArticle

2 days ago • Journal of advanced research

Ziyu glycoside I may reduce aging and improve age-related decline by stabilizing an enzyme and restoring lactate productionZiyu glycoside I suppresses senescence and ameliorates age-related functional decline by stabilizing LDHA and restoring lactate output.

🥉 Top 5% JournalArticle

3 days ago • Journal of ethnopharmacology

Dendrobium officinale extract may improve Alzheimer's by affecting cell growth and recycling processesDendrobium officinale extract ameliorates Alzheimer's disease by modulating PI3K-AKT-mTOR pathway and autophagy-related processes: An integrated study combining feature-based molecular networking, network pharmacology and multi-omics.

📖 Top 20% JournalArticle

3 days ago • iScience

Genes linked to mitochondria cleanup that may help diagnose focal segmental glomerulosclerosisIdentification of mitophagy-related genes with diagnostic value in focal segmental glomerulosclerosis using bioinformatics analysis.

🎖️ Top 10% JournalArticle

3 days ago • The American journal of medicine

Current approaches to treating Alzheimer's diseaseCurrent development of therapeutic strategies for Alzheimer's disease.

📖 Top 20% JournalArticle

3 days ago • Journal of orthopaedic translation

Changing immune cells in joint and muscle diseases: from local tissue roles to treatment possibilitiesMacrophage reprogramming in degenerative musculoskeletal diseases: From tissue-niche biology to therapeutic translation.

🎖️ Top 10% JournalArticle

3 days ago • Geriatric nursing (New York, N.Y.)

Understanding Long Life in Nursing: A Framework to Improve Healthy YearsConceptualizing longevity in nursing: a multidimensional framework for healthspan optimization.

📖 Top 20% JournalArticle

4 days ago • Immunity

Amount of mitochondrial DNA influences immune-triggered cancer cell deathMitochondrial DNA abundance is a determinant of immunogenic cell death in cancer.

🥇 Top 1% JournalArticle

4 days ago • Molecular neurobiology

Exercise and the removal of damaged cell parts in brain stroke: how it works, exercise approaches, and challenges for real-world useExercise and Mitophagy in Cerebral Ischemia: Mechanistic Evidence, Exercise Strategies, and Translational Challenges.

🎖️ Top 10% JournalArticle

4 days ago • Journal of Alzheimer's disease : JAD

How SGLT2 Inhibitors May Protect Brain Cells in Alzheimer's DiseaseDeciphering the neuroprotective signaling of SGLT2 inhibitors in Alzheimer's disease.

📖 Top 20% JournalArticle

4 days ago • Journal of Alzheimer's disease : JAD

Levels of p62 protein in spinal fluid linked to tau buildup, brain changes, and thinking problems in adults without dementiaCerebrospinal fluid p62/SQSTM1 is associated with tau pathology, brain structural alterations, and cognitive impairment in adults without dementia.

📖 Top 20% JournalArticle

4 days ago • Science advances

LAMP2A gene therapy reduces Parkinson's disease symptoms in primatesLAMP2A gene therapy mitigates Parkinson's disease-related pathology in nonhuman primates.

🥈 Top 2% JournalArticle

5 days ago • Biomolecules & therapeutics

Nrf2 Activation Causes Aging in Skin Support Cells and Increases Pigment Storage When Skin Cells Grow TogetherNrf2 Activation Induces Fibroblast Senescence and Promotes Melanosome Accumulation in a Fibroblast-Keratinocyte Co-Culture Model.

📖 Top 20% JournalArticle

5 days ago • Biogerontology

A task-focused approach to evaluating molecular clocks that estimate biological agingBeyond age prediction: a task-oriented framework for evaluating molecular aging clocks.

📖 Top 20% JournalArticle

5 days ago • Molecular metabolism

Immunotherapy against a natural viral element reduces aging signs in insulin-producing cells and helps maintain blood sugar control in a mouse model of type 2 diabetesImmunotherapy targeting an endogenous retrovirus decreases islet senescence markers and preserves glucose control in a mouse model of type 2 diabetes.

🥉 Top 5% JournalArticle

5 days ago • Cell reports

FXR/Sptlc2 signaling in severe lung injury helps lung immune cells clear damaged mitochondria and reduce inflammationAcute respiratory distress syndrome FXR/Sptlc2 signaling promotes alveolar macrophage mitophagy and limits lung inflammation.

🥈 Top 2% JournalArticle

5 days ago • Cell

Calorie restriction changes mutation rate independently of lifespanCalorie restriction uncouples mutation rate from lifespan.

🏆 Top 0.1% JournalComment

6 days ago • Chinese journal of natural medicines

CCA, a natural compound from Caesalpinia bonduc, improves memory problems in Alzheimer's mice by reducing brain inflammation and supporting cell cleanupCCA, a cassane diterpene from Caesalpinia bonduc ameliorates cognition impairment in Alzheimer's disease mice by regulating neuroinflammation and autophagy.

📖 Top 20% JournalArticle

6 days ago • Translational research : the journal of laboratory and clinical medicine

Removing TRPV4 in appetite-controlling neurons worsens diet-induced obesity through calcium-linked mitochondrial recyclingDeletion of TRPV4 in the POMC neurons exacerbates diet-induced obesity via Ca2+-dependent PGAM5-mediated mitophagy.

🥉 Top 5% JournalArticle

6 days ago • Seminars in respiratory and critical care medicine

Lymphangioleiomyomatosis (LAM): From Genetic Causes to Treatment ApproachesLymphangioleiomyomatosis (LAM): From Genetics to Management.

📖 Top 20% JournalArticle

6 days ago • Autophagy

Exercise causes a chemical change in WDR41 that starts cell cleaning and helps improve fatty liver diseaseExercise-induced lactylation in WDR41 initiates autophagy and improves fatty liver diseases.

🥈 Top 2% JournalArticle

6 days ago • Journal of agricultural and food chemistry

How DEHP May Promote Liver Scarring by Activating Fat Breakdown in Liver Support CellsExploring the Mechanism of DEHP Promoting Hepatic Fibrosis Based on Network Toxicology by Triggering Lipophagy-Dependent Hepatic Stellate Cell Activation.

📖 Top 20% JournalArticle

6 days ago • Research (Washington, D.C.)

Making Cell Communication Channels Using a Chinese MicroneedlePositioning Creation of Cell Communication Channels via Chinese Microneedle.

🥉 Top 5% JournalArticle

6 days ago • Signal transduction and targeted therapy

Ginsenoside Rb1 may reduce uterine aging by blocking a key cell growth pathwayGinsenoside Rb1 alleviates uterine aging via AMPK-mediated mTOR inactivation.

🥇 Top 1% JournalArticle

1 week ago • Signal transduction and targeted therapy

The AMPK pathway's role in cell energy use and human diseasesThe AMPK signaling pathway in cell metabolism and human diseases.

🥇 Top 1% JournalArticle

1 week ago • Experimental neurology

Exosomes from stem cells may improve memory and Alzheimer-like brain changes in mice by altering metabolismhucMSC-derived exosomes rescue cognitive impairment and Alzheimer-like pathology in APP/PS1 mice via metabolic remodeling.

🎖️ Top 10% JournalArticle

1 week ago • Current opinion in pediatrics

Telomere biology disorders seen through clinical geneticsTelomere biology disorders: recognizing the underrecognized through the lens of clinical genetics.

📖 Top 30% JournalArticle

1 week ago • npj aging

Using Biological Age and Artificial Intelligence in Health CareThe use of biological age and artificial intelligence in health care.

🥉 Top 5% JournalLetter

1 week ago • Circulation research

Natural Killer Cell Signals Control Lung Growth After BirthNatural Killer Cell TGF-β Signaling Regulates Postnatal Lung Development.

🥇 Top 1% JournalArticle

1 week ago • Expert opinion on therapeutic targets

Therapeutic potential of different sirtuin proteinsWhat are the potentials of the different sirtuin proteins as therapeutic targets?

📖 Top 20% JournalArticle

← prevpage 5 of 16next →

Longevity & Aging Research Papers