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4 days ago • Journal of ethnopharmacology

Asiaticoside may reduce aging of blood vessel cells in diabetic eye disease by boosting cell cleanup through the PI3K/AKT/mTOR pathwayAsiaticoside attenuates endothelial cells senescence in diabetic retinopathy via CCND1-mediated mitophagy through the PI3K/AKT/mTOR pathway.

📖 Top 20% JournalArticle

4 days ago • Sports medicine and health science

How exercise changes waste recycling systems in skeletal muscleExercise-induced lysosomal adaptations in skeletal muscle.

📖 Top 30% JournalArticle

4 days ago • Stem cells (Dayton, Ohio)

Using Stem Cells and Empagliflozin to Improve Cell Recycling and Protective Proteins in Diabetic Kidney DiseaseMesenchymal Stem Cells and Empagliflozin: a potential therapeutic approach for autophagy and Klotho modulation in Diabetic Kidney Disease.

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4 days ago • Biogerontology

Advances in Traditional Chinese Medicine for Nervous System Diseases Related to AgingResearch progress of traditional Chinese medicine interventions for aging-related nervous system diseases.

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4 days ago • Molecular neurobiology

Fixing Energy Problems in Brain Immune Cells as a New Approach to Treat Brain Degenerative DiseasesTargeting Mitochondrial Dysfunction in Microglia: A New Frontier for Treating Neurodegenerative Diseases.

🎖️ Top 10% JournalArticle

4 days ago • Molecular neurobiology

How Waste Removal and Inflammation in Brain Support Cells Are Linked in Alzheimer's DiseaseThe Glial Autophagy-Lysosomal-Inflammation Axis in Alzheimer's Disease: a Unifying Mechanistic Framework.

🎖️ Top 10% JournalArticle

5 days ago • Cell reports

Nutrient stress triggers a recycling process controlled by RAB5B to change proteins at nerve connectionsNutrient stress activates RAB5B-mediated autophagy to remodel the synaptic proteome.

🥈 Top 2% JournalArticle

5 days ago • RNA (New York, N.Y.)

Disease mutations in two parts of dyskerin do not stop it from pairing but disrupt its binding to telomerase RNADisease mutations in the N-terminal extension and α2'-helix of dyskerin do not abolish dimerization but disrupt binding to the telomerase RNA.

🥉 Top 5% JournalArticle

5 days ago • Immunity & ageing : I & A

Cell aging as a hidden cause of long-lasting skin inflammationCellular senescence: the "hidden driver" in chronic inflammatory skin disorders.

🎖️ Top 10% JournalArticle

5 days ago • Ageing research reviews

Cell Aging Linked to Both Getting Older and Coronary Artery DiseaseCellular senescence at the bidirectional interface between ageing and coronary artery disease.

🥈 Top 2% JournalArticle

5 days ago • Research in veterinary science

Blocking histone deacetylase changes gene activity related to cell growth and aging in horse cartilage cellsHistone deacetylase inhibition alters mRNA expression of cell cycle- and senescence-associated genes in primary equine chondrocytes.

📖 Top 50% JournalArticle

5 days ago • Science advances

Engineered tiny regulators linking heart and liver boost cell recycling and body metabolism to fight artery diseaseEngineered heart-liver axis nanoregulators synergize autophagy activation and systemic metabolic reprogramming against atherosclerosis.

🥈 Top 2% JournalArticle

5 days ago • Zoological research

Lack of DNAJB6a may cause tau buildup by triggering cell stress that harms mitochondriaDNAJB6a deficiency induces tau pathology through IRE1α-Xbp1-induced mitochondria dysfunction.

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5 days ago • European journal of clinical nutrition

Intermittent fasting: Effects, how it works, and important precautions for health and daily lifeIntermittent fasting: Impact, mechanisms and cautions across medical and lifestyle domains.

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5 days ago • Ageing research reviews

Physical and Mechanical Features of Cell Aging and Their Use in TreatmentsThe Physical Senotype in cellular senescence: Mechanical and physical strategies for senotherapy.

🥈 Top 2% JournalArticle

5 days ago • Phytomedicine : international journal of phytotherapy and phytopharmacology

Galangin reduces UVB-caused skin aging by activating a protein that controls cell cleaningGalangin attenuates UVB-induced skin photoaging through SIRT1-dependent LC3 deacetylation and autophagy modulation.

🎖️ Top 10% JournalArticle

5 days ago • Autoimmunity reviews

Aging of the immune system in lupus: harmful processes and treatment possibilitiesSenescence of the immune system in SLE: Pathogenic mechanisms and therapeutic implications.

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5 days ago • Phytomedicine : international journal of phytotherapy and phytopharmacology

Naringin reduces damage to brain cell energy structures and overactive cleanup after stroke by affecting specific protein pathwaysNaringin reduces mitochondrial fragmentation and excessive mitophagy in cerebral ischemia-reperfusion injury via the S-nitrosylated Dynamin-related protein 1 (SNO-DRP1) / Leucine-rich repeat kinase 2 (LRRK2) / Mitochondrial Calcium Uniporter (MCU) pathway.

🎖️ Top 10% JournalArticle

6 days ago • Phytomedicine : international journal of phytotherapy and phytopharmacology

Poricoic acid A reduces ulcerative colitis by blocking cell aging through the AMPK/PPARγ pathway and changing gut bacteria and their metabolismPoricoic acid a ameliorates ulcerative colitis via AMPK/PPARγ pathway-dependent cellular senescence inhibition and concomitant gut microbiota-metabolome modulation.

🎖️ Top 10% JournalArticle

6 days ago • Nature aging

Chemotherapy-caused cell aging releases factors that help cancer cells detach and spread by changing their metabolismThe chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming.

🥇 Top 1% JournalArticle

6 days ago • Autophagy

Using diet to improve cell cleanup reduces age-related heart scarring and stiffnessTargeting chaperone-mediated autophagy by nutritional interventions mitigates age-related cardiac fibrosis and diastolic dysfunction.

🥈 Top 2% JournalArticle

6 days ago • Autophagy

Turning off V-ATPase triggers cell recycling and abnormal Notch signaling to help intestinal stem cells develop in adult fruit fliesInactivation of V-ATPase induces autophagy and ectopic Notch activation to promote intestinal stem cell differentiation in adult drosophila midgut.

🥈 Top 2% JournalArticle

6 days ago • Phytomedicine : international journal of phytotherapy and phytopharmacology

Salidroside may reduce liver scarring from fatty liver disease by controlling cell cleanup through the PI3K/AKT/mTOR pathwaySalidroside alleviates metabolic dysfunction-associated steatohepatitis-induced fibrosis by regulating PI3K/AKT/mTOR pathway-mediated hepatocyte mitophagy.

🎖️ Top 10% JournalArticle

6 days ago • RSC medicinal chemistry

Testing pyrazolo-pyrimidines as inhibitors of the SIRT2 enzyme using computer models and lab experimentsProbing pyrazolo-pyrimidines as SIRT2 inhibitors via molecular modelling and biological assays.

📖 Top 30% JournalArticle

1 week ago • International journal of biological sciences

Cleaning, Repairing, and Soothing: Promising Approaches to Treat Aging-Related DiseasesCleaning, Chasing and Calming: Promising Paradigms of Senotherapy in Aging-Related Diseases.

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1 week ago • Nature reviews. Genetics

How Genes and Their Regulation Control Cell AgingGenomic, epigenomic and transcriptomic regulation of cellular senescence.

🥇 Top 1% JournalArticle

1 week ago • Ageing research reviews

The complosome's role in controlling cell aging, overall aging, and diseases linked to agingComplosome as a key modulator of cellular senescence, aging and age-related diseases.

🥈 Top 2% JournalArticle

1 week ago • Biogerontology

AGGF1 may slow aging in blood vessel cells through a specific cell signaling pathway involving TGFB3, TAK1, and AMPKAGGF1 delays endothelial cellular senescence through the TGFB3-TAK1-AMPK signaling axis.

📖 Top 20% JournalArticle

1 week ago • iScience

🎖️ Top 10% JournalArticle

1 week ago • Ageing research reviews

How the body’s microbes relate to health and aging from primates to humansFrom primates to people: Mapping host-microbiome-health relationships in aging.

🥈 Top 2% JournalArticle

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Longevity & Aging Research Papers