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1 week ago • Cell reports

Early problems in mitochondrial cleanup and energy use may drive organ damage progression in Fabry heart diseaseEarly mitophagy defects and impaired mitochondrial energy metabolism drive target organ damage progression: Lessons from the Fabry heart.

🥈 Top 2% JournalArticle

1 week ago • iScience

How specific cell types in memory and hormone control areas respond to nutrition and metabolism in Alzheimer's diseaseHippocampal and hypothalamic cell-type specific mechanisms underlying nutritional and metabolic modulation of Alzheimer's disease.

🎖️ Top 10% JournalArticle

1 week ago • Ecotoxicology and environmental safety

Mitochondria quality control during cadmium brain poisoning: helpful cleanup, uneven removal, and blocked processingMitochondrial quality-control states in cadmium neurotoxicity: Adaptive clearance, disproportionate elimination and stalled flux.

🎖️ Top 10% JournalArticle

1 week ago • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Finding compounds that target bitter taste receptors to slow metabolic decline using a new lab method measuring hormone and inflammation signalsIdentification of TAS2R-targeting bioactive compounds against metabolic decline: A novel ex vivo methodology based on enteroendocrine and inflammatory readouts.

🎖️ Top 10% JournalArticle

1 week ago • Nature reviews. Cardiology

Heart and blood vessel strength in people aged 100 and olderCardiovascular resilience in centenarians.

🥇 Top 1% JournalArticle

1 week ago • Trends in molecular medicine

Understanding Kidney Cancer by Studying MiT/TFE ProteinsRethinking kidney cancer through the lens of microphthalmia (MiT)/transcription factor E (TFE) Biology.

🥈 Top 2% JournalArticle

1 week ago • Food & function

Energy-regulating pathways help grape waste extract protect against obesity-related chronic kidney disease in miceAMPK-dependent mechanisms mediate the protective effects of grape pomace extract in obesity-associated chronic renal disease in mice.

📖 Top 20% JournalArticle

1 week ago • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Using protective blood pressure system pathways to reduce inflammation and restore lung balance in emphysemaTargeting protective renin-angiotensin system pathways in pulmonary emphysema: Preclinical evidence for resolving inflammation and restoring lung homeostasis.

🎖️ Top 10% JournalArticle

1 week ago • Autophagy

A specific protein modification helps build a gene-regulating complex that controls cell cleanup and protein balance in non-dividing eye support cellsAKT1-phosphorylated TERT assembles a FOXO3-MYC transcriptional complex that drives ERphagy and proteostasis in post-mitotic RPE.

🥈 Top 2% JournalArticle

1 week ago • Journal of cardiovascular translational research

Protein Modifications Linked to Irregular Heartbeats in Atrial FibrillationPost-Translational Protein Acylation in Atrial Fibrillation.

📖 Top 30% JournalArticle

1 week ago • Materials today. Bio

Nanoparticles that renew aged LepR+ cells to improve old bone marrowAged microenvironment-triggered nanoreactors rejuvenate senescent LepR+ cells to remodel aged bone marrow.

🥉 Top 5% JournalArticle

1 week ago • Biogerontology

Ginsenoside Rg1 may slow aging by boosting cell cleanup through DAF-16 in C. elegansGinsenoside Rg1 promotes mitophagy and delays aging through the DAF-16 in Caenorhabditis elegans.

📖 Top 20% JournalArticle

1 week ago • Autophagy

Mitochondrial membrane rupture allows prohibitin 2 to link bacteria and attract E3 ligase to trigger mitochondrial bacterial clearanceMitochondrial membrane rupture licenses prohibitin 2-mediated bacterial tethering and E3 ligase recruitment to drive mito-xenophagy.

🥈 Top 2% JournalArticle

1 week ago • Autophagy

ATG9 and ATG2 as lipid regulators linking cell recycling and vesicle releaseATG9 and ATG2 as lipid managers at the crossroads of autophagy and extracellular vesicle secretion.

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1 week ago • Free radical biology & medicine

Dioscin reduces liver damage from aniline by targeting a fat-processing pathway, lowering harmful molecules, and restoring cell energy and cleanup systemsDioscin attenuates aniline-induced liver injury by targeting the ACOT2-mediated ROS-JAK2/STAT3-CLN5 axis and restoring mitochondrial fatty acid oxidation and lysosomal lipophagy.

🥉 Top 5% JournalArticle

1 week ago • Journal of Alzheimer's disease : JAD

Cell-free DNA changes in spinal fluid reflect disease biology in tau-related brain disordersCerebrospinal fluid cell-free DNA methylation captures disease-specific biology in tauopathies.

📖 Top 20% JournalArticle

1 week ago • Journal of Alzheimer's disease : JAD

A possible iron-related process in Alzheimer's disease: from iron imbalance and aging to iron-driven cell deathA putative iron-related evolving framework in Alzheimer's disease: From iron dyshomeostasis and ferro-aging to ferroptosis.

📖 Top 20% JournalArticle

1 week ago • Autophagy

How gene activity controls cell cleanup: processes, timing, and drug effectsTranscriptional control of autophagy: mechanisms, dynamics, and pharmacological modulation.

🥈 Top 2% JournalArticle

1 week ago • Seminars in nephrology

Intestinal Phosphate Absorption and Phosphate Metabolism in Chronic Kidney Disease: Direct and Indirect Toxicity of Phosphate Additives in Ultra-processed Diets.Intestinal Phosphate Absorption and Phosphate Metabolism in Chronic Kidney Disease: Direct and Indirect Toxicity of Phosphate Additives in Ultra-processed Diets.

📖 Top 20% JournalArticle

1 week ago • Journal of Alzheimer's disease : JAD

How immune cell waste processing problems may cause brain inflammation in Alzheimer's and potential treatment targetsPathogenesis and therapeutic targets of neuroinflammation in Alzheimer's disease mediated by microglia lysosomal dysfunction.

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1 week ago • Experimental eye research

How Cellular Recycling Affects Eye Health and Disease, and Possible TreatmentsAutophagy in ocular health and disease: From mechanistic insights to therapeutic perspectives.

📖 Top 20% JournalArticle

1 week ago • Autophagy

Understanding Cell Death That Depends on the Body’s Recycling Process: Key Ideas, Signs, and How It HappensA Guide to autophagy-dependent cell death: concepts, criteria, and mechanisms.

🥈 Top 2% JournalArticle

1 week ago • Experimental neurology

NEFL helps DJ-1 protect nerve cells and regulate cell cleanup in Alzheimer's-like damageNEFL contributes to DJ-1-mediated neuroprotection and autophagic flux regulation in Alzheimer's disease-like injury.

🎖️ Top 10% JournalArticle

1 week ago • European journal of pharmacology

Understanding the Two Roles of NADPH Oxidase 4 in Heart Scarring to Guide Targeted TreatmentsResolving the dual nature of NADPH oxidase 4 in cardiac fibrosis for selective therapeutic targeting: A narrative review.

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1 week ago • iScience

Stathmin 1 controls mitochondrial cleanup and non-dividing functions in blood stem and early cellsStathmin 1 regulates mitophagy and non-proliferative cellular function in hematopoietic stem and progenitor cells.

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1 week ago • Ageing research reviews

Brain cell loss in Sub-Saharan Africa linked to aging, genetic differences, and lifelong environmental exposuresNeurodegeneration in sub-Saharan Africa: Intersections of biological ageing, genomic diversity and the lifetime exposome.

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1 week ago • Kidney360

Cell Aging as a Key Link between Chronic Kidney Disease, Heart Scarring, and AgingCellular Senescence as a Core Mechanistic Link between CKD, Cardiac Fibrosis, and Aging.

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1 week ago • Inflammation and regeneration

Microglia Energy Problems as a New View of Depression CausesMitochondrial dysfunction in microglia: a novel perspective of depression pathogenesis.

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1 week ago • Journal of medicinal chemistry

Krüppel-like Factors as Timed Regulators of Cell Recycling That Influence Cell Survival and DiseaseKrüppel-like Factors in Autophagy: A Spatiotemporal Rheostat Framework Linking Cellular Fate and Disease.

🎖️ Top 10% JournalArticle

1 week ago • Ageing research reviews

Understanding Aging Cells in Heart Failure: Key Processes and Potential TreatmentsMapping cellular senescence in heart failure: knowledge evolution, mechanistic modules, and senotherapeutic opportunities.

🥈 Top 2% JournalArticle

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Longevity & Aging Research Papers