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2 weeks ago • Free radical biology & medicine

Misfolding of a key enzyme disrupts energy production and balance in mitochondriaMisfolding of cystathionine beta-synthase impairs mitochondrial homeostasis and cellular bioenergetics.

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2 weeks ago • Science China. Life sciences

Single-cell analysis reveals changes in gene variants and immune cells during human agingSingle-cell multi-omics dissects transcript isoform and immune repertoire dynamics in human immunosenescence.

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2 weeks ago • Molecular neurobiology

Isorhapontigenin may protect the brain from inflammation-related damage by affecting immune response pathwaysNeuroprotective Effect of Isorhapontigenin (ISO) Against LPS-Induced Neurodegenerative Condition via TLR4/RAGE-Mediated p-NF-kB Activation.

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2 weeks ago • ACS applied materials & interfaces

Repeated Pressure Shows Age-Related Inflammation in Human Stem Cell ClustersDynamic Compression Reveals Donor-Age-Associated Inflammaging in Human Mesenchymal Stromal Cell Spheroids.

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2 weeks ago • Ageing research reviews

Oxidation Changes in SOD1 Protein and Their Role in Skin Aging: What We Know and What Needs More StudyPosttranslational Oxidation of SOD1 and Skin Aging: Evidence, Gaps, and Future Directions.

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2 weeks ago • Nature reviews. Neurology

The role of the complement immune system and related treatments in brain diseasesRole of complement and complement-targeted therapeutics in neurological diseases.

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2 weeks ago • Ageing research reviews

Understanding and Treating Alzheimer's by Focusing on Mitochondria FunctionTargeting the mitochondrial functional network: Decoding upstream pathological mechanisms and novel therapeutic paradigms for Alzheimer's disease.

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2 weeks ago • Journal of ethnopharmacology

Lactiflorin may help stop a damaging cycle of cell cleanup and stress in Alzheimer's by activating key cell repair signalsBreaking the autophagy-oxidative stress vicious cycle in Alzheimer's disease: Lactiflorin unlocks P62 dual phosphorylation via ULK1 targeting.

📖 Top 20% JournalArticle

2 weeks ago • Arthritis & rheumatology (Hoboken, N.J.)

CASTOR1 controls immune responses in the blood and may contribute to lupus developmentCASTOR1 regulates humoral immune responses and contributes to the pathogenesis of systemic lupus erythematosus.

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2 weeks ago • Journal of the National Cancer Institute

Psychological distress in adults with colorectal cancer linked to biological age and neighborhood disadvantagePsychological distress in adult patients with colorectal cancer: roles of biological age and neighborhood deprivation.

🥇 Top 1% JournalArticle

2 weeks ago • JOR spine

Understanding the Role of Oxygen-Sensing Proteins in Spinal DiscsMy Love Story With HIFs in the Disc: A Journey to the Humboldt Research Award.

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2 weeks ago • Science advances

Step-by-step process of bringing ULK1 protein to membranes during cell cleanupReconstitution of multistep recruitment of ULK1 to membranes in autophagy.

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2 weeks ago • International journal of biological macromolecules

Seaweed Sugars Help Reduce UV Skin Aging by Repairing Outer Skin and Rebuilding Support LayersPolysaccharides from Sargassum fusiforme attenuate UV-induced skin photoaging via epidermal repair and dermal matrix reconstruction.

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2 weeks ago • Biogerontology

Stress and metabolic ageing in older adults during long crises, shown by UkraineStress biology and metabolic ageing in older adults during prolonged crises: Ukraine as an example.

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2 weeks ago • Carbohydrate polymers

How Cichorium glandulosum polysaccharides may protect against muscle loss and obesity by triggering cell cleanup through the butyrate-GPR43-AMPK pathwayStructure and protection of Cichorium glandulosum polysaccharides against sarcopenic obesity through activating mitophagy via butyrate-GPR43-AMPK pathway.

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2 weeks ago • Stroke

Blocking Immune Checkpoint B7-H3 May Change Early Brain Inflammation and Protect the Brain After StrokeImmune Checkpoint B7-H3 Inhibition Reprograms Acute Neuroinflammation and Protects the Brain After Acute Ischemic Stroke.

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2 weeks ago • Neurochemical research

Mild Cooling May Reduce Tissue Damage After Blood Flow Loss by Triggering Cell Cleanup ProcessesMild Hypothermia Alleviates Ischemia and Reperfusion Injury by Activating PINK1/Parkin Mitophagy.

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2 weeks ago • Journal of Huntington's disease

Selective cleanup of damaged proteins with helper molecules in polyglutamine diseases: from how it works to possible treatmentsChaperone-assisted selective autophagy (CASA) in polyglutamine-related diseases: From mechanisms to therapeutic perspectives.

🎖️ Top 10% JournalArticle

2 weeks ago • Journal of agricultural and food chemistry

Lycopene reduces fat-induced cell damage and death in cow mammary cells by activating cell cleanup processes controlled by TFEBLycopene Alleviates Fatty Acid-Induced Oxidative Stress and Apoptosis in Bovine Mammary Epithelial Cells via the TFEB-Mediated Autophagy Signaling Pathway.

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2 weeks ago • JBMR plus

Creating human stem cells with spCAS9 to study gene roles in bone cell developmentGeneration of spCAS9 expressing human mesenchymal stem cell line to study gene function during osteoblast differentiation.

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2 weeks ago • Annual review of pathology

Problems with Cell Cleanup in Nerve and Muscle Diseases: From Genetic Causes to Treatment ProgressAutophagy Deficits in Lower Motor Neuron and Striated Muscle Diseases: From Genetics to Therapeutic Advances.

🥇 Top 1% JournalArticle

2 weeks ago • Seminars in nephrology

How Sudden Kidney Injury May Lead to Long-Term Kidney Disease: Clinical Signs, Underlying Causes, and Potential Use of Traditional Chinese MedicineAcute Kidney Injury-to-Chronic Kidney Disease Transition: Clinical Evidence, Pathophysiologic Mechanisms, and Emerging Role of Traditional Chinese Medicine.

📖 Top 20% JournalArticle

2 weeks ago • GeroScience

Assessing Frailty in Naturally Aging Mice: Types, Challenges, and Future StepsFrailty assessment in naturally aged mouse models: classification, limitations, and future directions.

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2 weeks ago • Biogerontology

Using nanoparticles to improve treatments for aging-related cell declineClosing the gap in aging science: unlocking the potential of nanoparticles in senescence therapy.

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2 weeks ago • Molecular and cellular endocrinology

Glucose and blood factors adjust nerve cell metabolism and influence insulin signalingGlucose and serum availability fine-tune neuronal metabolic adaptations and direct insulin signaling.

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2 weeks ago • Free radical biology & medicine

Metformin may slow disc degeneration by triggering a cell stress response through energy regulation pathwaysMetformin activates the mitochondrial unfolded protein response via the AMPK/SIRT1 pathway to delay intervertebral disc degeneration.

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2 weeks ago • Science advances

Fluorescent protein ticker tape: Recording multiple gene activity patterns in living cells and animalsFluorescent protein ticker tape (FPTT): Multiplexed recording of transcriptional dynamics in living cells and in vivo.

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2 weeks ago • Antioxidants & redox signaling

Mitochondrial Microautophagy as a New Way Cells Keep Mitochondria BalancedMitochondrial Microautophagy: An Emerging Pathway in Maintaining Mitochondrial Homeostasis.

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2 weeks ago • The Journal of animal ecology

How males and females respond differently to warming over time, linked to aging markers, enzyme activity, and cell stressSex-specific responses to warming: A longitudinal study linking life-history variation to telomere dynamics, telomerase expression and oxidative stress.

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2 weeks ago • Inflammopharmacology

How lithium, magnesium, and zinc affect protein balance linked to Alzheimer's disease under stressThe lithium-magnesium-zinc axis under stress: regulation of N-glycosylation-linked proteostasis and Alzheimer's disease.

📖 Top 20% JournalArticle

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