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1 week ago • Autophagy

Reducing SSH1 boosts cell cleanup by attracting ATG9A and helps break down tau proteinSSH1 knockdown increases autophagosome formation through ATG9A recruitment and promotes tau protein degradation.

🥈 Top 2% JournalArticle

1 week ago • Molecular neurobiology

β-Asarone reduces brain inflammation after stroke and improves mitochondrial health through a specific cellular cleanup processβ-Asarone Alleviates Post-stroke Neuroinflammation and Improves Mitochondrial Quality Via the BNIP3/BNIP3L-dependent Mitophagy Pathway.

🎖️ Top 10% JournalArticle

1 week ago • Redox biology

Reducing harmful molecules in joint tissue may lower cell death and slow osteoarthritisModulating the synovial ROS-NO-RNS network attenuates fibroblast-like synoviocyte pyroptosis and osteoarthritis progression.

🥈 Top 2% JournalArticle

1 week ago • Ecotoxicology and environmental safety

Long-term exposure to the tire chemical 6-PPDQ may cause aging signs and movement and behavior problems through ABL1-p53-autophagy signalingChronic exposure to the tire-wear contaminant 6-PPDQ induces senescence-associated biomarkers and neurobehavioral deficits: Involvement of ABL1-p53-autophagy signaling.

🎖️ Top 10% JournalArticle

1 week ago • The Journal of nutritional biochemistry

Selenium reduces cadmium-caused ovary scarring by preventing aging of immune cells in chickensSelenium alleviates cadmium-induced ovarian fibrosis by inhibiting macrophage senescence in chickens.

📖 Top 20% JournalArticle

1 week ago • Cell death and differentiation

Fhl2 increases cartilage cell death in osteoarthritis by disrupting mitochondrial cleanup through microtubule disorganizationFhl2 promotes chondrocyte ferroptosis in osteoarthritis by impairing mitophagic flux through microtubule disorganization.

🥇 Top 1% JournalArticle

1 week ago • Cell metabolism

How bone sensing of movement slows aging and may extend lifespanDynamic force sensing by bone delays aging and extends lifespan.

🥇 Top 1% JournalArticle

1 week ago • Biogerontology

Resveratroloside reduces aging signs in cells by improving energy production and DNA organizationResveratroloside alleviates senescence-associated phenotypes in vitro through the coordinated regulation of mitochondrial function and chromatin structure.

📖 Top 20% JournalArticle

1 week ago • Materials today. Bio

Nature-inspired tiny cages that target damaged kidneys for combined diagnosis and treatment of sudden blood flow injuryBiomimetic nanocages with cascade homing for theranostics of ischemia-reperfusion acute kidney injury.

🥉 Top 5% JournalArticle

1 week ago • GeroScience

What dog lifespan treatments can teach us about human healthLessons from dog lifespan therapeutics for their human companions.

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1 week ago • Brain pathology (Zurich, Switzerland)

Galectin-3 may protect against prion disease by helping brain immune cells clear harmful proteinsProtective role of Galectin-3 in prion disease through regulation of microglial PrPSc uptake.

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1 week ago • Ageing research reviews

Selective Removal of Cell Stress Structures by Receptors in Brain Diseases: How It Works and Possible TreatmentsReceptor-Specific ER-Phagy in Neurodegenerative Diseases: Molecular Mechanisms and Emerging Therapeutic Opportunities.

🥈 Top 2% JournalArticle

1 week ago • Food research international (Ottawa, Ont.)

Better long-term growth and muscle development of cow muscle stem cells by editing the CDKN2A geneImproved long-term proliferation and myogenic differentiation of bovine muscle stem cells through CDKN2A gene editing.

🎖️ Top 10% JournalArticle

1 week ago • Nature aging

Key gene activity patterns linked to aging in blood vessel lining cells revealed by single-cell analysisUncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis.

🥇 Top 1% JournalArticle

1 week ago • Trends in endocrinology and metabolism: TEM

How the recovery period after childbirth may influence aging in mothersThe postpartum recovery window as a determinant of maternal aging.

🥈 Top 2% JournalArticle

1 week ago • Oral diseases

RIPK3 may increase gum cell death and gum inflammation by disrupting cell cleanupRIPK3 Promotes Gingival Fibroblast Apoptosis and Periodontal Inflammatory Injury by Impairing Mitophagy.

📖 Top 20% JournalArticle

1 week ago • Pharmacological research

A modified chalcone compound reduces Alzheimer's Aβ and Tau problems by affecting energy control and cell cleanup processesA trifluoromethylated chalcone derivative attenuates Alzheimer disease-related Aβ/Tau pathology by modulating the AMPK-dependent autophagy-proteostasis axis.

🥉 Top 5% JournalArticle

1 week ago • Nano letters

Tiny Polymer Dot Reactors for Highly Sensitive Detection of Various Metabolites and On-the-Spot DiagnosisNanoconfined Polymer Dot Reactors for Ultrasensitive Monitoring of Diverse Metabolites and Point-of-Care Diagnosis.

🥉 Top 5% JournalArticle

1 week ago • Advanced healthcare materials

Nanoparticles Targeting Cell Energy Centers May Reduce Cell Aging by Restoring Energy Balance in OsteoarthritisMitochondria-Targeted Supramolecular Nanoparticles Alleviate Cellular Senescence by Restoring Mitochondrial Homeostasis in Osteoarthritis.

🥉 Top 5% JournalArticle

1 week ago • Annual review of physiology

Aging of Muscle Cells: How It Happens, Its Effects on the Body, and Possible TreatmentsCellular Senescence in Skeletal Muscle: Molecular Mechanisms, Physiological Consequences, and Therapeutic Opportunities.

🥇 Top 1% JournalArticle

1 week ago • hLife

Former Regulatory T Cells: From Misunderstood Artifact to Potential Treatment TargetEx-Tregs: From controversial artifact to therapeutic target.

📖 Top 20% JournalArticle

1 week ago • Free radical biology & medicine

How nerve cell stress and damaged mitochondria lead to brain immune cell inflammation after radiation injuryNeuronal oxidative stress and mitophagy contribute to microglial inflammation in radiation-induced brain injury.

🥉 Top 5% JournalArticle

1 week ago • Environment & health (Washington, D.C.)

Using Tiny Gold Nanoparticles to Reduce Early Ovarian Failure Caused by Environmental Pollutants by Controlling Cell Stress and Mitochondrial CleanupMitigating Environmental Pollutant-Induced Premature Ovarian Insufficiency by Rationally Designed Ultrasmall Gold Nanoparticles via Dual Regulation of ROS and Mitophagy.

🎖️ Top 10% JournalArticle

1 week ago • European journal of medicinal chemistry

New Lac-Phe Compounds with Better Absorption for Treating Metabolic SyndromeDiscovery of novel Lac-Phe derivatives with improved oral exposure for the treatment of metabolic syndrome.

📖 Top 20% JournalArticle

1 week ago • Cell structure and function

Cell stress changes mitochondrial amounts and placement of an antioxidant protein during cell agingProteostasis stress alters mitochondrial levels and localization of SOD2 during cellular senescence.

📖 Top 20% JournalArticle

1 week ago • Cell communication and signaling : CCS

Iron buildup as a possible cause of aging-related bone and joint diseasesFerro-aging: a potential driver of degenerative bone and joint diseases.

🥉 Top 5% JournalArticle

1 week ago • Ecotoxicology and environmental safety

Single-cell gene analysis shows dopamine-producing neurons may be vulnerable to self-cleaning process changes after atrazine exposureSingle-cell transcriptomic analysis reveals autophagy-associated transcriptional vulnerability of dopaminergic neurons after atrazine exposure.

🎖️ Top 10% JournalArticle

1 week ago • Channels (Austin, Tex.)

Possible roles of a temperature- and pain-sensing receptor in heart failure with normal pumping functionPotential roles for transient receptor potential vanilloid 1 in heart failure with preserved ejection fraction.

📖 Top 20% JournalArticle

1 week ago • Journal of molecular neuroscience : MN

GBA1 gene variant rs12411216 linked to movement and non-movement problems and worse progression in Parkinson's disease over five yearsThe GBA1-related variant rs12411216 is Associated with Motor and Non-Motor Impairments and Unfavorable Progression in Parkinson's Disease: A Five-Year Longitudinal Study.

📖 Top 20% JournalArticle

1 week ago • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Response to 'Intermittent Fasting and Brain Protection After Stroke'EXPRESS: Letter to the Editor Regarding "Much ado about eating: Intermittent fasting and post-stroke neuroprotection".

🥉 Top 5% JournalLetter

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Longevity & Aging Research Papers