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2 weeks ago • Biogerontology

CD44 as a key controller of aging-related inflammation, cell cleanup, and tissue balanceFrom matrix to nucleus: CD44 as a central regulator of inflammaging, autophagy, and tissue homeostasis.

📖 Top 20% Journal

2 weeks ago • European journal of pharmacology

A key protein controlling cell cleaning and brain inflammation in Alzheimer's diseaseRepressor Element 1 Silencing Transcription Factor as a central regulator of autophagy and neuroinflammation in Alzheimer's disease.

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2 weeks ago • GeroScience

How cell stress affects aging, cell aging, and brain degenerationThe PERK paradox in aging: how ER stress shapes senescence and neurodegeneration.

🎖️ Top 10% Journal

2 weeks ago • Journal of agricultural and food chemistry

18β-Glycyrrhetinic Acid may protect fat tissue from age-related inflammation in diet-induced obese miceProtective Effects of 18β-Glycyrrhetinic Acid against Inflammaging in Adipose Tissue of Diet-Induced Obese Mice.

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2 weeks ago • Neurology

Senescence Gene Activity Linked to 90-Day Recovery Outcomes in Stroke PatientsSenescence Gene Expression Profiles and 90-Day Outcome in Stroke Patients.

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2 weeks ago • Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

SIRT Genes Help Protect Zebrafish Ovaries from Damage Caused by Plastic NanoparticlesThe SIRT gene family protects against oxidative stress and mitochondrial dynamic dysfunction induced by polystyrene nanoplastics in the ovaries of zebrafish (Danio rerio).

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2 weeks ago • Journal of medicinal chemistry

Improving p62-Targeting AUTOTACs to Better Break Down Cancer-Related Proteins EGFR and VEGFR2 and Fight TumorsStructure-Guided Optimization of p62-Directed AUTOTACs for Efficient EGFR/VEGFR2 Degradation and Antitumor Efficacy.

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2 weeks ago • Ageing research reviews

Changes in Gut Microbes with Aging and Their Links to Immune and Metabolic Control Over Time and Body AreasMicrobiome remodeling during aging: Integrative multi-omics and spatiotemporal perspectives on immune and metabolic regulation.

🥈 Top 2% Journal

2 weeks ago • Translational research : the journal of laboratory and clinical medicine

How SGLT2 inhibitors and GLP-1 receptor agonists work together in treating chronic kidney diseaseFrom FLOW to translational positioning in chronic kidney disease: mechanistic complementarity of SGLT2 inhibitors and GLP-1 receptor agonists.

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2 weeks ago • GeroScience

DNA methylation patterns linked to high blood pressure and inherited biological aging markers in Korean adultsHypertension-associated DNA methylation signatures and multi-generational epigenetic clocks in Korean adults.

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2 weeks ago • Neurochemical research

Fat Imbalance Causes Brain Mitochondria Problems That Don’t Reach Disease Levels in ApoE-Deficient MiceDyslipidemia-Induced Mitochondrial Dysfunctions in the Brains Does Not Reach Pathological Levels in the ApoE-Knockout Mice.

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2 weeks ago • BMC pregnancy and childbirth

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2 weeks ago • American journal of epidemiology

How the length, timing, and level of neighborhood poverty from adolescence to early middle age relate to biological agingNeighborhood poverty duration, timing, and severity from adolescence to early midlife and biological aging.

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2 weeks ago • Annual review of genetics

How Cells Detect and Respond to NutrientsDesign Principles and Architecture of Cellular Nutrient Signaling.

🥇 Top 1% Journal

2 weeks ago • Colloids and surfaces. B, Biointerfaces

pH-sensitive chitosan nanoparticles for targeted delivery of nicotinamide mononucleotide in treating acute kidney injurypH-responsive chitosan-based nanoparticles for targeted delivery of nicotinamide mononucleotide in acute kidney injury therapy.

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2 weeks ago • Advanced materials (Deerfield Beach, Fla.)

Nanoparticles that deliver protons and electrons together may restore energy production and help bone regrow during agingPCET-Inspired Nanoparticles Enable Paired Proton-Electron Delivery to Restore Mitochondrial Electron Transport and Regenerate Bone During Aging.

🥇 Top 1% Journal

2 weeks ago • Journal of applied physiology (Bethesda, Md. : 1985)

Effects of 8 Weeks of Short Exercise Sessions on Muscle Oxygen Use, Heart and Metabolism Health, Mitochondria, and Early Artery Disease Signs in Inactive WomenEffects of 8-Week Exercise Snacks on Muscle Oxygenation and Cardiometabolic, Mitochondrial and Subclinical Atherosclerosis Markers in Sedentary Women.

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2 weeks ago • Reproductive sciences (Thousand Oaks, Calif.)

Using Data Analysis and Testing to Identify Two Mitophagy-Related Proteins as Diagnostic and Treatment Targets in Polycystic Ovary SyndromeBioinformatics, Machine Learning and Functional Validation Reveal Mitophagy-Related FABP5 and HMOX1 as Diagnostic and Therapeutic Targets in Polycystic Ovary Syndrome.

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2 weeks ago • American journal of respiratory cell and molecular biology

High oxygen levels in newborns may cause aging of immune cells and lung damage through a stress-related protein pathwayNeonatal hyperoxia promotes macrophage senescence and lung injury via a p38MAPK-dependent secretome.

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2 weeks ago • Drugs & aging

Bronchiectasis in Older Adults: Unique Causes, Diagnosis, and Disease Progress Compared to Younger PeopleBronchiectasis in Older Adults: Distinctive Epidemiology, Etiology, Diagnosis, and Clinical Evolution Compared with Younger Populations.

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2 weeks ago • Pharmacological research

Frailty as a problem with how energy systems adapt, from energy overload to overall weaknessRethinking frailty as a disorder of mitochondrial adaptability, from energetic congestion to systemic vulnerability.

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2 weeks ago • Ageing research reviews

Blood as a Key Link for Treatments Targeting AgingThe circulating senosome: Blood as the therapeutic interface of aging.

🥈 Top 2% Journal

2 weeks ago • Journal of nanobiotechnology

Microspheres that remove harmful molecules and carry cell signals to treat spinal disc degenerationROS-scavenging microspheres loaded with extracellular vesicles for intervertebral disc degeneration therapy.

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2 weeks ago • Molecular neurobiology

How DNA Detection Triggers Brain Inflammation and Potential Treatments for Age-Related Brain DiseasesDNA Sensing and Neuroinflammation: Mechanistic Insights into cGAS-STING Biology and Therapeutic Translation in Age-Related Neurodegenerative Diseases.

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2 weeks ago • Free radical biology & medicine

Controlling cell cleanup and inflammation from mitochondrial DNA to treat bone loss caused by inflammationDual-regulation of mitophagy and cytosolic mtDNA-induced inflammation for the treatment of inflammatory bone loss.

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2 weeks ago • Ageing research reviews

Aging of brain blood vessel support cells linked to blood-brain barrier problems in Alzheimer's disease: causes, effects, and treatment possibilitiesNeurovascular unit senescence as a driver of blood-brain barrier dysfunction in Alzheimer's disease：Mechanisms, consequences, and therapeutic implications.

🥈 Top 2% Journal

2 weeks ago • Cell reports

TTYH3 controls chloride flow in lysosomes and affects their fusion, cell recycling, and agingTTYH3 regulates a lysosomal chloride conductance and controls lysosomal fusion, autophagy and senescence.

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2 weeks ago • Translational stroke research

PIP4K2A may reduce brain damage after stroke by lowering harmful protein buildup and adjusting cell survival signalsPIP4K2A Attenuates Cerebral Ischemia/Reperfusion Injury by Reducing the TRIB3-p62 Complex Burden and Modulating AKT/mTOR Signaling.

🎖️ Top 10% Journal

2 weeks ago • Ecotoxicology and environmental safety

Spermidine reduces egg cell damage from chemical exposure by restoring normal cell cleanup processes in miceSpermidine alleviates 2,2-dichloroacetamide/ 2,2-dibromoacetamide-exposed mouse oocyte toxicity by restoring autophagic homeostasis.

🎖️ Top 10% Journal

2 weeks ago • Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

Faster Heart Ageing in Heart Disease: Findings from Heart Imaging and Electrical TestsAdvancing Heart Ageing in Ischemic Heart Disease: Insights from CMR and ECG Analysis.

🎖️ Top 10% Journal

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Longevity & Aging Research Papers