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2 weeks ago • Ageing research reviews

How heart and brain age together: different patterns, underlying molecular causes, and possible treatmentsHeart-brain co-ageing: Phenotypic heterogeneity, molecular mechanisms and translational interventions.

🥈 Top 2% JournalArticle

2 weeks ago • Environmental pollution (Barking, Essex : 1987)

Short-term ozone exposure causes lung problems in older mice shown by multiple biological analysesAcute ozone exposure induced lung impairments in aged mice: multi-omics evidence.

🥉 Top 5% JournalArticle

2 weeks ago • Journal of advanced research

Removal of damaged mitochondria and cell cleanup in heart damage caused by doxorubicin: how they interact and potential treatmentsMitophagy and ER-phagy in doxorubicin-induced cardiotoxicity: mechanisms, crosstalk, and therapeutic implications.

🥉 Top 5% JournalArticle

2 weeks ago • The Journal of biological chemistry

EPG5 controls iron storage by regulating two steps in the breakdown of large iron-storage complexesEPG5 orchestrates iron compartmentalization through dual regulation in macroferritinophagy.

🎖️ Top 10% JournalArticle

2 weeks ago • Ecotoxicology and environmental safety

Vitamin C may reduce air pollution-related thyroid problems and cell cleanup imbalance by restoring calcium balance between cell compartmentsVitamin C attenuates PM2.5-induced thyroid dysfunction and mitophagy dysregulation by rebalancing ER-mitochondrial Ca²⁺ dynamics.

🎖️ Top 10% JournalArticle

2 weeks ago • Pharmacological research

How Fat Storage Structures and Energy Centers Work Together and Their Roles in DiseasesMechanisms of lipid droplet-mitochondria interactions and their roles in diseases.

🥉 Top 5% JournalArticle

2 weeks ago • Science advances

A Hydrogel System for Spinal Disc Repair by Targeting Cell Energy Centers and Boosting Cell CleanupA "Progenitor Cell Ark" hydrogel system for intervertebral disc regeneration via mitochondrial targeting and mitophagy enhancement.

🥈 Top 2% JournalArticle

2 weeks ago • Biogerontology

Hippo-YAP/TAZ signaling in brain aging and neurological disorders: key mechanisms, interactions, and treatment possibilitiesHippo-YAP/TAZ signalling at the crossroads of brain ageing and neurological disorders: mechanisms, crosstalk, and therapeutic prospects.

📖 Top 20% JournalArticle

2 weeks ago • International journal of pharmaceutics: X

Near-infrared activated prodrug that coordinates heat shock protein and drug resistance responses with impaired mitochondrial cleanup to overcome natural heat toleranceRedox-metabolic cascade NIR-II prodrug for synchronizing compensatory HSPs/P-gp feedback with mitophagy flux impairment against intrinsic thermotolerance.

📖 Top 20% JournalArticle

2 weeks ago • Developmental cell

Mitochondria trigger two processes that cause cells to release aging-related signalsMitochondria strike two hits to drive the SASP.

🥇 Top 1% JournalComment

2 weeks ago • Drug design, development and therapy

New Insights into Schaftoside: How It Works, Moves Through the Body, and Its Treatment PotentialAdvances in Schaftoside Research: Pharmacological Mechanisms, Pharmacokinetics, and Therapeutic Perspectives.

📖 Top 20% JournalArticle

2 weeks ago • Molecular neurobiology

Restoring Brain Balance by Modulating Class II HDAC Proteins: Mechanisms and Treatment PossibilitiesRestoring Neural Homeostasis via Class II HDAC Modulation: Mechanistic Insights and Therapeutic Opportunities.

🎖️ Top 10% JournalArticle

3 weeks ago • Neuroscience and biobehavioral reviews

How Older Parents May Influence Their Children's Aging, Lifespan, and Risk of Brain DiseasesThe intergenerational clock: How advanced parental age shapes offspring biological aging, longevity and neurodegenerative risk.

🥉 Top 5% JournalArticle

3 weeks ago • The FEBS journal

Specific cell cleaning processes in aging and brain diseases: New roles for mitochondrial and nuclear removalSelective autophagy pathways in ageing and neurodegeneration: Emerging roles for mitophagy and nucleophagy.

🥉 Top 5% JournalArticle

3 weeks ago • Ageing research reviews

How Diet May Slow Brain Aging and Neurodegenerative DiseasesThe mechanism of dietary intervention in delaying brain aging and neurodegenerative diseases.

🥈 Top 2% JournalArticle

3 weeks ago • Ageing research reviews

How Exercise May Affect DNA Changes Linked to Alzheimer's Across GenerationsExercise, DNA methylation, and Alzheimer's disease: Mechanistic links and future directions in intergenerational research.

🥈 Top 2% JournalArticle

3 weeks ago • Neuroinformatics

Using Natural Plant Compounds to Influence Mitochondrial Splitting and Recycling Processes in Brain Disorders by Targeting ROCK ProteinsTargeting ROCK Isoforms by Natural Phytocompounds: An In-Silico Approach to Modulate Mitochondrial Fission and Mitophagy in Neurological Diseases.

📖 Top 20% JournalArticle

3 weeks ago • International journal of pharmaceutics: X

Lactoferrin-modified stem cell vesicles help cross the brain barrier and boost gastrodin’s nerve protection in Parkinson’s disease through cell cleanup processesLactoferrin-modified MSC-derived extracellular vesicles facilitate BBB penetration and enhance gastrodin-induced neuroprotection in Parkinson's disease: involvement of mitophagy.

📖 Top 20% JournalArticle

3 weeks ago • Ageing research reviews

Cell Aging in Heart Failure with Normal Pumping: Causes and Possible TreatmentsCellular senescence in heart failure with preserved ejection fraction: Mechanisms and therapeutic opportunities.

🥈 Top 2% JournalArticle

3 weeks ago • BMJ open

Effects of HMB and 2-HOBA supplements on health markers in older adults: protocol for a Canadian clinical trialEffects of β-hydroxy-β-methylbutyrate (HMB) and/or 2-hydroxybenzylamine (2-HOBA) on markers of healthspan in older adults (H2AGE trial): study protocol of a randomised controlled trial at the Canadian Translational Geroscience Network.

📖 Top 20% JournalArticle

3 weeks ago • Ecotoxicology and environmental safety

Possible ways the chemical DEHP may cause bone loss, shown by combining network analysis and lab testsElucidation of the potential mechanisms of di-2-ethylhexyl phthalate (DEHP)-associated osteoporosis by integrating network toxicology and in vitro validation.

🎖️ Top 10% JournalArticle

3 weeks ago • Stem cells (Dayton, Ohio)

Senescent Bone Cell Signals Linked to Localized Tissue Changes and Stiffness in Human Brain ModelsParacrine Bone-Derived Senescent Secretome is Associated with Spatially Patterned ECM Remodeling and Altered Biomechanics in Human Brain Organoids.

📖 Top 20% JournalArticle

3 weeks ago • Skin pharmacology and physiology

Using a Yeast Protein Extract to Activate SIRT6 and Improve Skin Aging by Targeting Key Aging ProcessesActivation of SIRT6 Using a Hydrolyzed Yeast Protein Extract to Enhance Skin Longevity by Targeting Multiple Hallmarks of Aging.

📖 Top 30% JournalArticle

3 weeks ago • Drug design, development and therapy

Chinese Herbal Medicine for Insomnia: From Laboratory Findings to Clinical UseFrom Mechanistic Evidence to Clinical Translation: A Narrative Review of Chinese Herbal Medicine for Insomnia.

📖 Top 20% JournalArticle

3 weeks ago • Experimental eye research

Naringin reduces eye surface inflammation in dry eye disease by boosting cell cleaning and lowering oxidative stress through the PI3K/AKT/mTOR pathwayNaringin alleviates ocular surface inflammation in dry eye disease by enhancing autophagic flux and mitigating oxidative stress through downregulation of the PI3K/AKT/mTOR pathway.

📖 Top 20% JournalArticle

3 weeks ago • Pharmacological research

Camellioside A may activate cell cleanup pathways to reduce UVB-related skin agingCamellioside A engages SIRT3 to promote FOXO3-PINK1/parkin dependent mitophagy and attenuate UVB-induced skin photoaging.

🥉 Top 5% JournalArticle

3 weeks ago • Science China. Life sciences

Inflammation as a key factor in the development and treatment resistance of acute myeloid leukemiaInflammation as a central driver in AML pathogenesis and therapy resistance.

🥉 Top 5% JournalArticle

3 weeks ago • Aging and disease

Mitochondria’s usual and unusual roles in stroke and agingMitochondria Beyond Bioenergetics: Canonical and Non-Canonical Functions in Ischemic Stroke and Aging.

🥉 Top 5% JournalArticle

3 weeks ago • Ageing research reviews

How Changes in Cellular Energy Signals Connect Aging Signs to Chronic InflammationTHE AGING PURINOME: A PURINERGIC FRAMEWORK LINKING THE HALLMARKS OF AGING TO INFLAMMAGING.

🥈 Top 2% JournalArticle

3 weeks ago • Journal of advanced research

Hyodeoxycholic acid may help bone stem cells fight aging and abnormal fat buildup in postmenopausal osteoporosis through a specific cell cleanup pathwayHyodeoxycholic acid rejuvenates BMSCs against postmenopausal osteoporosis by attenuating senescence and aberrant adipogenesis via TGR5-ESR1-mediated mitophagy.

🥉 Top 5% JournalArticle

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Longevity & Aging Research Papers