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3 weeks ago • Ageing research reviews

Brain Aneurysms Linked to Early Blood Vessel Aging, Cell Aging, Chronic Inflammation, and Vessel Wall DamageIntracranial aneurysms as a manifestation of premature vascular aging: Cellular senescence, inflammaging, and wall degeneration.

🥈 Top 2% JournalArticle

3 weeks ago • Chemical & biomedical imaging

Bright Fluorescent Probe for Clear, Even Imaging of Cell Recycling Activity in Live CellsFluorogenic Autophagic Vesicle-Engaging Probe Enables High-Contrast and Homogeneous Imaging of Autophagic Flux in Live Cells.

🎖️ Top 10% JournalArticle

3 weeks ago • Signal transduction and targeted therapy

How miR-150 controls stem cell fate by regulating SOX2 through mRNA suppression and cell recyclingDual-mode SOX2 regulation by miR-150 via mRNA suppression and autophagy controls stem cell fate.

🥇 Top 1% JournalArticle

3 weeks ago • Journal of assisted reproduction and genetics

Ovarian aging: biological limits and new treatment possibilitiesOvarian ageing: from biological constraint to emerging therapeutic frontier.

📖 Top 20% JournalArticle

3 weeks ago • Current opinion in pharmacology

Using mitochondria to treat inflammation and tissue damage: how it works, markers to track, and challenges for medical useMitochondria as a therapeutic platform in inflammatory and degenerative disorders: mechanisms, biomarkers, and translational challenges.

🎖️ Top 10% JournalArticle

3 weeks ago • Journal of molecular medicine (Berlin, Germany)

SREBF2 supports removal of damaged mitochondria and protects heart cells from iron-related damage through Cav-1 controlled PINK1/Parkin pathway in heart failure caused by low blood flowSREBF2 promotes mitophagy and protects against ferroptosis via Cav-1-regulated PINK1/Parkin signaling in ischemic heart failure.

🎖️ Top 10% JournalArticle

3 weeks ago • Nature aging

Mice lacking cGAS show early aging linked to activation of repetitive DNA and inflammationcGAS-deficient mice display premature aging associated with derepression of LINE1 elements and inflammation.

🥇 Top 1% JournalArticle

3 weeks ago • Neurochemical research

Changes in Cell Cleanup Processes Linked to Thinking Problems in Alcohol-Dependent Rats on a High-Fat DietFoxO3a-Smad4 Co-localization and Autophagy Alterations are Associated with Cognitive Impairment in Alcohol-Dependent Rats Fed a High-Fat Diet.

📖 Top 20% JournalArticle

3 weeks ago • Neuroscience and biobehavioral reviews

Gene Activity, Brain Inflammation, and Brain Adaptability in Type 2 Diabetes: Insights from Exercise and Mental TrainingTitle: Gene Expression, Neuroinflammation, and Neural Plasticity in Type 2 Diabetes: Translational Insights from Exercise and Cognitive Modulation.

🥉 Top 5% JournalArticle

3 weeks ago • Angewandte Chemie (International ed. in English)

A Designed Tool for Tracking and Controlling Cell Recycling ActivitySemi-Synthetic LC3-Interacting Degrader for Visualizing Macroautophagic Activity and Targeted Degradation.

🥇 Top 1% JournalArticle

3 weeks ago • Environment & health (Washington, D.C.)

Air Pollution Particles May Cause Lung Blood Vessel Changes by Aging Lung Vessel Lining Cells Through Stem Cell ActivityAmbient PM2.5 Induced Pulmonary Vascular Remodeling via MSC-Mediated Cellular Senescence in Pulmonary Arterial Endothelial Cells.

🎖️ Top 10% JournalArticle

3 weeks ago • Autophagy

Heat stress triggers selective removal of cell parts in yeastHeat shock-induced autophagy has cargo selectivity in Saccharomyces cerevisiae.

🥈 Top 2% JournalArticle

3 weeks ago • Circulation research

Removal of damaged mitochondria helps maintain protein balance in cells to protect heart functionMitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function.

🥇 Top 1% JournalArticle

3 weeks ago • Science China. Life sciences

The cGAS-STING system in age-related inflammation and brain inflammationThe cGAS-STING pathway in inflammaging and neuroinflammation.

🥉 Top 5% JournalArticle

3 weeks ago • Biogerontology

An important aging topic: connecting aging science with the publicAn aging essential 8: closing the gap between geroscience and the public it serves.

📖 Top 20% JournalArticle

3 weeks ago • Nature aging

A probiotic and its active compound may reduce age-related inflammation to improve healthy agingA geroprotective probiotic and its functional metabolite counteract inflammaging to extend healthspan.

🥇 Top 1% JournalArticle

3 weeks ago • BMC medicine

JP1 peptide may reduce cell damage and support cell cleanup systems through antioxidant pathways in ALS model miceJP1 peptide modulates oxidative stress and autophagy via Keap1-Nrf2-ARE in ALS model mice.

🥉 Top 5% JournalArticle

3 weeks ago • Journal of inherited metabolic disease

A Modern Classification of Inherited Lysosomal Diseases Based on Their Underlying CausesA Contemporary Pathomechanistic Nosology of Inherited Lysosomal Disorders.

📖 Top 20% JournalArticle

3 weeks ago • The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry

Roles and Location of NMNAT2 in Controlled Nerve Fiber BreakdownNMNAT2 Functional Landscape and Localization in Programmed Axon Degeneration.

🎖️ Top 10% JournalArticle

3 weeks ago • Archives of pharmacal research

Plant-based anti-inflammatory compounds from medicinal herbs linked to aging-related inflammation for healthy agingAnti-inflammatory phytochemicals from medicinal herbs based on senoinflammation schema for healthy aging.

🎖️ Top 10% JournalArticle

3 weeks ago • Drug design, development and therapy

Remimazolam May Reduce Brain Injury After Trauma by Boosting Mitochondrial Cleanup and Lowering Cell Inflammation in Brain Immune CellsRemimazolam Attenuates Neurological Injury After TBI: A Potential Role of α7nAChR-Associated Mitophagy Enhancement and Pyroptosis Suppression in BV2 Cells.

📖 Top 20% JournalArticle

3 weeks ago • The Journal of dermatology

Resveratrol May Reduce Age-Related Skin Thinning in Mice by Activating SIRT1SIRT1 Activator Resveratrol Attenuates Age-Related Skin Thinning in Mice.

📖 Top 20% JournalArticle

3 weeks ago • Tissue barriers

Understanding the complex biological processes of skin aging and new methods for diagnosis and treatmentDecoding the multidimensional landscape of skin aging: molecular pathways and next-generation diagnostics & therapeutics.

🎖️ Top 10% JournalArticle

3 weeks ago • Acta neuropathologica communications

Lower small blood vessel coverage connects low-oxygen areas to microglia recycling problems in Parkinson's diseaseReduced microvascular coverage links a hypoxia-associated niche to microglial autophagic dysfunction in Parkinson's disease.

🥉 Top 5% JournalArticle

3 weeks ago • Biogerontology

How gut bacteria may influence aging: molecular clues from a tiny wormAging regulation by gut microbiota: molecular insights from Caenorhabditis elegans.

📖 Top 20% JournalArticle

3 weeks ago • Journal of ethnopharmacology

Herbal combination of Gastrodia elata and Acorus tatarinowii reduces seizures and brain damage in epilepsy rats by affecting cell cleanup and inflammation pathwaysGastrodia elata Blume-Acorus tatarinowii Schott herb pair alleviates seizures and hippocampal injury in TLE rats with alterations in mitophagy and NLRP3 inflammasome pathways.

📖 Top 20% JournalArticle

3 weeks ago • Chemical communications (Cambridge, England)

Label-free imaging shows higher water content and stiffness in cell nuclei during agingMultimodal label-free imaging reveals increased nuclear hydration and apparent stiffening during cellular senescence.

📖 Top 20% JournalArticle

3 weeks ago • Nature neuroscience

How the brain’s cell-cleaning process helps maintain balance and relates to diseaseRoles of autophagy in brain homeostasis and disease.

🥇 Top 1% JournalArticle

3 weeks ago • Journal of ethnopharmacology

Qinghuang Powder May Improve Cell Aging and Energy Problems in Bone Marrow Stem Cells of Myelodysplastic SyndromesQinghuang powder ameliorates cellular senescence and energy metabolism abnormalities in bone marrow mesenchymal stem cells of myelodysplastic syndromes.

📖 Top 20% JournalArticle

3 weeks ago • Ageing research reviews

The Grandmother Hypothesis and How Heart and Blood Vessel Aging Relate to ItThe Grandmother Hypothesis: A perspective from cardiovascular aging.

🥈 Top 2% JournalArticle

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Longevity & Aging Research Papers