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3 weeks ago • Food & function

Resveratrol from food helps several generations of C. elegans resist infection through p38 MAPK and DAF-16 pathwaysFood-derived resveratrol confers multigenerational host defense against PA14 via p38 MAPK and DAF-16 signaling in C. elegans.

📖 Top 20% JournalArticle

3 weeks ago • Food research international (Ottawa, Ont.)

Gut bacteria-produced short-chain fatty acids help the anti-aging effects of a plant fiber by regulating immune cells in the intestines of miceGut microbiota-derived SCFAs mediate the intestinal anti-aging effect of structurally characterized Dendrobium officinale glucomannan via Treg immune regulation in mice.

🎖️ Top 10% JournalArticle

3 weeks ago • The Journal of biological chemistry

How ERα and SIRT1 signals help pterostilbene improve metabolismERα/SIRT1 signaling mediates the metabolic regulatory benefits of pterostilbene.

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3 weeks ago • International journal of biological macromolecules

Protein phosphatase 2A controls cell recycling in spinal disc center and may worsen damage through the AKT/mTOR pathwayProtein phosphatase 2A regulates nucleus pulposus autophagy and aggravates degeneration via the AKT/mTOR pathway.

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4 weeks ago • Translational stroke research

MCC950, an NLRP3 inhibitor, may improve stroke recovery in aging miceTherapeutic Potential of NLRP3 Inhibitor MCC950 in Aging Mice Stroke Outcomes.

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4 weeks ago • GeroScience

Using biological aging measures in healthcare to improve personalized long-term healthIntegrating biological aging into clinical practice: a review and path forward for precision longevity medicine.

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4 weeks ago • Ageing research reviews

Elastin Fragments May Promote Aging by Activating the Immune SystemThe Dark Side of the Matrix: Elastin-Derived Fragments Drive Aging by Igniting the Immune System.

🥈 Top 2% JournalArticle

4 weeks ago • Ageing research reviews

Exercise and p21 Signaling in Brain Aging and Cell Aging: Effects Depend on Context and AmountExercise and p21 signaling in central nervous system aging and senescence: A context- and dose-dependent relationship.

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4 weeks ago • Ageing research reviews

How Traditional Chinese Medicine May Slow Blood Vessel Aging at the Cell and Molecular LevelCounteracting vascular ageing with Traditional Chinese Medicine: Mechanisms at the cellular and molecular levels.

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4 weeks ago • Ageing research reviews

How Aging Muscle Limits Cell Therapy: Cell Types, Tissue Environment Problems, and Self-Donor OptionsAgeing of the skeletal muscle as a barrier to cell therapy: Cell sources, microenvironmental failure and autologous alternatives.

🥈 Top 2% JournalArticle

4 weeks ago • Research (Washington, D.C.)

Overactive PDHA1 Changes Cell Metabolism to Promote Aging in Blood Vessel CellsPDHA1 Hyperactivation Orchestrates Metabolic Reprogramming Promoting Endothelial Senescence.

🥉 Top 5% JournalArticle

4 weeks ago • Pharmacological research

Mitochondria-focused control networks in fatty liver disease: linking cell cleanup, organ interactions, and gut-liver communicationMitochondrial-centric regulatory networks in MASLD: Integrating quality control, organelle interactions, and gut-liver communication.

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4 weeks ago • Experimental eye research

Lycium barbarum polysaccharides may reduce fat buildup and aging caused by a high-fat diet by activating fat recycling in cellsLycium barbarum polysaccharides ameliorates high-fat diet induced lipid accumulation and aging through triggering lipophagy.

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4 weeks ago • European journal of pharmacology

Early resveratrol exposure causes different blood vessel effects in adult rats: protective in high blood pressure rats but harmful in normal ratsDevelopmental exposure to resveratrol induces context-dependent vascular effects in adult offspring: protection in SHR and adverse remodeling in normotensive rats.

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4 weeks ago • GeroScience

Using DNAm PhenoAge as an epigenetic marker to predict risk in adult spinal deformity surgeryExamination of DNAm PhenoAge as an epigenetic biomarker for perioperative risk in adult spinal deformity surgeries.

🎖️ Top 10% JournalArticle

4 weeks ago • Chinese journal of natural medicines

Natural compounds targeting mitochondria with potential to treat mitochondrial diseasesMitochondria-targeted natural products with potential for the treatment of mitochondria-related diseases.

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4 weeks ago • Child development

Peer bullying, feeling accepted at school, and biological aging in children of Latino immigrantsPeer victimization, school belonging, and epigenetic aging among children of Latino immigrants.

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4 weeks ago • Spinal cord

Challenges and considerations for using NAD+ supplements and PARP blockers after spinal cord injury in miceNAD+ supplementation and PARP inhibition following spinal cord injury in mice: Hurdles and considerations for therapeutic use.

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4 weeks ago • Chemico-biological interactions

PGAM5 helps form VDAC1 clusters that may increase ponatinib heart damage by disrupting the combined mitochondrial cleanup and stress responsePGAM5-mediated VDAC1 oligomerization facilitates ponatinib-induced cardiotoxicity via disrupting the mitophagy-mitochondrial unfolded protein response synergistic defense crosstalk.

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4 weeks ago • Molecular & cellular proteomics : MCP

Nicotinamide mononucleotide and glucose together reduce iron-related energy problems in mice under low oxygen pressureNicotinamide mononucleotide combined glucose counteracts iron overload induced mitochondrial dysfunction in mice under hypobaric hypoxia.

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4 weeks ago • Ageing research reviews

Lasting effects of aging cells on tissue repair may cause ongoing organ problems in chronic diseaseSenescent repair memory in chronic disease: Failed resolution as a driver of persistent organ dysfunction.

🥈 Top 2% JournalArticle

4 weeks ago • Ageing research reviews

How E3 Ubiquitin Ligases Help Fix Protein Balance Problems in AgingE3 Ubiquitin ligases molecular strategies against proteostasis defects of imperfect ageing.

🥈 Top 2% JournalArticle

4 weeks ago • American journal of nephrology

How Control of CCN1 Protein May Contribute to Muscle Loss in Chronic Kidney DiseaseThe Regulation of CCN1 Contributes to Skeletal Muscle Wasting in Chronic Kidney Disease.

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1 month ago • Phytomedicine : international journal of phytotherapy and phytopharmacology

Indole-3-propionic acid boosts cell cleanup and reduces cell death in blood vessel disease by targeting the 14-3-3θ proteinTargeting the 14-3-3θ protein with indole-3-propionic acid restores PINK1/Parkin mediated mitophagy and suppresses endothelial PANoptosis in atherosclerosis.

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1 month ago • iScience

Faster biological aging is linked to worse outcomes in frail ICU patientsAccelerated biological aging predicts poor outcomes in frail ICU patients.

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1 month ago • Ageing research reviews

Mitochondrial Problems in Brain Diseases: Causes and New TreatmentsMitochondrial dysfunction in neurodegenerative diseases: Mechanisms and therapeutic advances.

🥈 Top 2% JournalArticle

1 month ago • Phytomedicine : international journal of phytotherapy and phytopharmacology

Apigenin-7-O-glucoside from Gualou-Xiebai may reduce artery plaque by promoting fat-cleaning in vessel muscle cells through Rab7 and SNAP29Gualou-Xiebai-derived Apigenin-7-O-glucoside inhibits VSMCs foam cell formation and alleviates atherosclerosis by targeting Rab7 to drive SNAP29-dependent lipophagy.

🎖️ Top 10% JournalArticle

1 month ago • European journal of pharmacology

New SIRT1 Activator F1462 May Reduce Blood Vessel Aging by Boosting Mitochondria through the SIRT1/PGC-1α/TFAM PathwayNovel SIRT1 up-regulator F1462 attenuates endothelial cell senescence and vascular aging by promoting mitochondrial biogenesis via activating the SIRT1/PGC-1α/TFAM pathway.

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1 month ago • Genes & diseases

CCN1 may control microglia placement by region-specific cell interactionsSpatial transcriptomics revealed the regulatory role of CCN1 to microglia distribution through region-specific cellular interactions.

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1 month ago • Journal of advanced research

A cell aging pattern identifies COMP-positive support cells linked to CD8+ T-cell exclusion through a COMP-CD47 pathway in colorectal cancerTargeting a candidate stromal immune checkpoint: a cellular senescence signature identifies COMP⁺ cancer-associated fibroblasts associated with CD8⁺ T-cell exclusion via a predicted COMP-CD47 axis in colorectal cancer.

🥉 Top 5% JournalArticle

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Longevity & Aging Research Papers