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3 weeks ago • Experimental neurology

Drugs that affect NAD+ metabolism protect nerve fibers inside and outside the brain in a lab model of nerve injuryCombined pharmacological targeting of NAD+ metabolism preserves central and peripheral axons in an ex vivo model of Wallerian degeneration.

🎖️ Top 10% JournalArticle

3 weeks ago • Autophagy

Real-time imaging of cell cleaning processes in mice using advanced two-photon microscopyLive visualization of dynamic autophagy processes in LC3 reporter mice using enhanced two-photon microscopy.

🥈 Top 2% JournalArticle

3 weeks ago • Human reproduction update

Understanding how the immune system controls ovarian aging and possible treatmentsDecoding the immune regulation of ovarian aging: mechanisms and therapeutic strategies.

🥇 Top 1% JournalArticle

3 weeks ago • Autophagy

How TBK1 adds phosphate to WIPI2 to connect bacteria detection with autophagosome formation in cell cleaningTBK1-mediated phosphorylation of WIPI2 links bacteria recognition to autophagosome formation in xenophagy.

🥈 Top 2% JournalArticle

3 weeks ago • The Journal of physiology

Differences in Mitochondrial Changes and Repair in Two Mouse Models of Friedreich's AtaxiaMitochondrial dynamics and repair differences in two mouse models of Friedreich's ataxia.

🎖️ Top 10% JournalArticle

3 weeks ago • Trends in biochemical sciences

Metabolic enzymes acting as protein switches that add or remove phosphate groupsMetabolic enzymes moonlighting as protein kinases and phosphatases.

🥈 Top 2% JournalArticle

3 weeks ago • Ecotoxicology and environmental safety

Sodium arsenite speeds up aging in C. elegans parents and offspring through insulin signaling, oxidative stress, and cell cleanup processesSodium arsenite accelerates aging of Caenorhabditis elegans parents and offspring through the insulin signaling pathway, oxidative stress, and autophagy.

🎖️ Top 10% JournalArticle

3 weeks ago • Biosensors & bioelectronics

Metabolic chemical patterns predict aging and muscle cell development in immature muscle cellsElectrochemical metabolic profiling predicts senescence and myogenic fate in undifferentiated myoblasts.

🥉 Top 5% JournalArticle

3 weeks ago • Cell chemical biology

Blocking BRD4-BD1-p62 interaction may restore protective cell cleaning processDisrupting BRD4-BD1-p62 engagement restores protective autophagy.

🥉 Top 5% JournalArticle

3 weeks ago • Ageing research reviews

Using Mini-Organs to Study Cell Aging and Age-Related Diseases from Lab Models to Practical UsesOrganoids for modeling cellular senescence and age-related pathology: From experimental reconstruction to mechanistic and translational applications.

🥈 Top 2% JournalArticle

3 weeks ago • Free radical biology & medicine

Phosphodiesterase 4 inhibitors may extend worm lifespan and reduce cell aging in mouse cellsPhosphodiesterase 4 inhibitors extend lifespan of C. elegans and attenuate cellular senescence of mouse embryonic fibroblasts.

🥉 Top 5% JournalArticle

3 weeks ago • Nanomedicine : nanotechnology, biology, and medicine

Combined microRNA and resveratrol treatment targeting cell regulators reverses obesity in high-fat diet miceSynergistic prohibitin-targeted microRNA-resveratrol nanotherapy effectively reverses obesity in high-fat obese mice.

📖 Top 20% JournalArticle

3 weeks ago • Autophagy

Selective cell cleaning processes preserved across evolutionEvolutionarily conserved selective autophagy pathways.

🥈 Top 2% JournalArticle

3 weeks ago • Molecular neurobiology

Urolithin D Improves Thinking and Behavior in Aging Mice by Helping Cells Clear Damaged Mitochondria Through Energy and Survival PathwaysEllagitannin Metabolite Urolithin D Ameliorates Cognitive Function and Behavioral Performance in Aging Mice Partially via AMPK/PGC-1α/SIRT3-Dependent Regulation of Mitophagy-Related Molecular Machinery.

🎖️ Top 10% JournalArticle

3 weeks ago • Ageing research reviews

Could drugs targeting aged cells help treat giant cell arteritis?Is there a role for senotherapeutics in the treatment of giant cell arteritis?

🥈 Top 2% JournalArticle

3 weeks ago • Cell reports

Mitochondria transfer may protect against hearing loss from cisplatin by activating cell cleanup through fumarateMitochondrial transfer protects against cisplatin-induced hearing loss by fumarate-mediated activation of mitophagy.

🥈 Top 2% JournalArticle

3 weeks ago • Signal transduction and targeted therapy

Phospholipid phosphatase 2 supports liver healing and regrowth after sudden liver damagePhospholipid phosphatase 2 drives liver repair and regeneration after acute liver injury.

🥇 Top 1% JournalArticle

3 weeks ago • Ageing research reviews

Nanoparticle therapies targeting aging cells for healthier aging: design ideas, evidence, and challengesNanoparticle-based senolytic and senomorphic therapies for healthy aging: design principles, translational evidence, and challenges.

🥈 Top 2% JournalArticle

3 weeks ago • Microbial physiology

Improving Nicotinamide Mononucleotide Production by Engineering CpNampt Enzyme Mutants in YeastSemi-Rational Design of CpNampt Mutants for Enhanced Nicotinamide Mononucleotide (NMN) Synthesis in Saccharomyces cerevisiae.

📖 Top 20% JournalArticle

4 weeks ago • Glia

Light Therapy May Improve Alexander Disease by Boosting Cell Cleanup Through Energy RegulationPhotobiomodulation Ameliorates Alexander Disease Through AMPK/mTOR-Mediated Mitophagy.

🥉 Top 5% JournalArticle

4 weeks ago • Biogerontology

Sex differences in immune patterns across dog lifespans and short-term effects of anti-aging treatmentsSex-stratified immune patterns across the canine lifespan and short-term responses to geroprotective interventions.

📖 Top 20% JournalArticle

4 weeks ago • Journal of physiology and biochemistry

New processes of non-standard cell self-cleaning without ATG8Emerging mechanisms of ATG8-independent non-canonical autophagy.

📖 Top 20% JournalArticle

4 weeks ago • GeroScience

Links between overall aging, frailty, and changes in the retina using combined environmental and metabolic dataAssociation of systemic aging and frailty with retinal alterations: insights from an integrated exposome and metabolome framework.

🎖️ Top 10% JournalArticle

4 weeks ago • Circulation

The Oxidized Lipid PGPC Reduces New Blood Vessel Growth by Blocking Cell Cleanup Fusion Through NPC1-Triggered Changes in Syntaxin 17The Oxidized Phospholipid PGPC Impairs Angiogenesis by Inhibiting Endothelial Autophagosomal-Lysosomal Fusion Through NPC1-Induced Syntaxin 17 Acetylation and Ubiquitination.

🥇 Top 1% JournalArticle

4 weeks ago • Stem cell research & therapy

Potential of aging-targeting treatments for xeroderma pigmentosumSenotherapeutic potential against xeroderma pigmentosum.

🥉 Top 5% JournalArticle

4 weeks ago • Theriogenology

SIRT2 helps fix damaged mitochondria in older cow egg cells by changing SQSTM1 at a specific siteSIRT2-dependent SQSTM1 decrotonylation at K100 rescues impaired mitophagy in aged bovine oocytes.

📖 Top 30% JournalArticle

4 weeks ago • Small methods

Predicting Cell Aging Caused by Oxidative Stress and Cancer Drugs Using 3D Imaging and Explainable AIPrediction of Oxidative Stress- and Anticancer Drug-Induced Cellular Senescence Using Holotomography and Interpretable Attention-Based Contrastive Learning.

🥉 Top 5% JournalArticle

4 weeks ago • Nature reviews. Molecular cell biology

Selective Cell Cleanup and Recycling in Health, Disease, and AgingChaperone-mediated autophagy in physiological homeostasis, disease and ageing.

🏆 Top 0.1% JournalArticle

4 weeks ago • Best practice & research. Clinical rheumatology

New understanding of how osteoporosis develops and personalized treatment approachesNew insights into the pathogenesis of osteoporosis and the translational approach to personalized therapy.

🎖️ Top 10% JournalArticle

4 weeks ago • British journal of clinical pharmacology

Treatments that may reverse cell aging: Review of drugs and therapies tested in peopleTherapeutic reversal of cellular senescence: A systematic review of senolytics, senomorphics and anti-ageing therapies in human clinical trials.

📖 Top 20% JournalArticle

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