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3 weeks ago • Trends in cancer

A new way cancer may use self-cleaning processes to weaken the immune responseA novel mechanism of autophagy-dependent immunosuppression in cancer?

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3 weeks ago • Journal of translational medicine

Rapamycin treatment linked to changes in energy and inflammation processes and reduced fatigue in ME/CFS patients: early phase-II study resultsAssociation of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study.

🥉 Top 5% Journal

3 weeks ago • Journal of Alzheimer's disease : JAD

How Problems in the Cell's Waste-Removal System May Contribute to Alzheimer's DiseaseMechanisms of autophagy-lysosome pathway impairment in Alzheimer's disease.

📖 Top 20% Journal

3 weeks ago • Free radical biology & medicine

Lack of ASAP3 reduces liver aging and is linked to longer healthy life in miceASAP3 deficiency alleviates hepatic senescence and correlates with extended healthspan in mice.

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3 weeks ago • Experimental neurology

How communication between brain immune and support cells may worsen stroke damage and blood vessel weakness with ageMicroglia-astrocyte crosstalk-driven metabolic-inflammatory imbalance and cerebrovascular frailty in exacerbating stroke injury during aging.

🎖️ Top 10% Journal

3 weeks ago • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

The C5a protein and its receptor may promote the shift from sudden to chronic kidney damage by increasing cell cleanup processesC5a/C5aR1 mediates AKI-CKD transition by enhancing autophagy.

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3 weeks ago • GeroScience

🎖️ Top 10% Journal

3 weeks ago • Amino acids

L-citrulline’s effects on blood vessel health, artery stiffness, and heart metabolism during exercise in older and postmenopausal womenL-citrulline as a nitric oxide-modulating therapeutic adjunct to exercise: effects on vascular function, arterial stiffness, and cardiometabolic health in postmenopausal and older women.

📖 Top 30% Journal

3 weeks ago • Scientific reports

Thymoquinone's anti-inflammatory and antioxidant effects reduce early aging changes caused by D-galactose in miceAnti-inflammatory and anti-oxidative properties of thymoquinone attenuate D-galactose induced premature aging-associated alterations in mice.

📖 Top 20% Journal

3 weeks ago • Ageing research reviews

How Food Components Can Trigger or Protect Against Age-Related InflammationDietary Bioactive Compounds and Inflammaging: Pro-Inflammatory Triggers and Geroprotective Countermeasures.

🥈 Top 2% Journal

3 weeks ago • Molecular neurobiology

Small Protein Tagging in Mitochondrial Quality Control and Its Role in Brain Degeneration DiseasesSUMOylation in Mitochondrial Quality Control: Mechanisms and Implications for Neurodegenerative Disease.

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4 weeks ago • GeroScience

Removing or Changing Old Cells to Improve Skin HealthTargeting cellular senescence in dermatology: senolytic and senomorphic strategies.

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4 weeks ago • Autophagy

Low oxygen triggers a protein pathway that promotes cancer cell self-cleaning and spread in stomach cancerHypoxia-induced EPAS1/HIF2A-USP33-ATG101 axis drives oncogenic autophagy and peritoneal metastasis in gastric cancer.

🥈 Top 2% Journal

4 weeks ago • American journal of physiology. Lung cellular and molecular physiology

DNA methylation linked to aging of lung repair cells in COPDDNA methylation as a driver of lung fibroblast senescence in COPD.

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4 weeks ago • Translational psychiatry

The genetic link between ADHD and shorter cell aging markers suggests brain development involvementThe genetic relationship between ADHD and shortened telomeres points to neurodevelopmental mechanisms.

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4 weeks ago • Inflammopharmacology

Control of inflammatory signaling in Alzheimer's disease and the potential protective role of plant compoundsRegulation of NLRP3 inflammasome signaling in Alzheimer's disease: emerging neuroprotective role of phytochemicals.

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4 weeks ago • Diabetes

Higher Levels of a Key Enzyme in Fat Tissue May Protect Obese Mice from Metabolic Problems Through Tiny Messenger ParticlesAdipose Tissue Overexpression of Nicotinamide Phosphoribosyltransferase Prevents Metabolic Dysfunction in Obese Mice via Extracellular Vesicles.

🥉 Top 5% Journal

4 weeks ago • Molecular neurobiology

How Telomerase Location Inside Neurons Affects Control of Mitochondrial DNA Amount in Specific GenesSubcellular Localization of Telomerase Reverse Transcriptase Regulates Gene-Specific Modulation of Mitochondrial DNA Copy Number in Neuronal Cells.

🎖️ Top 10% Journal

4 weeks ago • Cell reports

A telomerase and SUCLG2 pathway may help drug-resistant persistent cells surviveA telomerase-SUCLG2 signaling axis drives drug resistance by protecting persister cells.

🥈 Top 2% Journal

4 weeks ago • Ageing research reviews

The Role of Cell Recycling, Aging, and Inflammation in Brain DegenerationThe Autophagy-Senescence-Inflammasome Axis: A Novel Triad in Neurodegenerative Diseases?

🥈 Top 2% Journal

4 weeks ago • Chemico-biological interactions

Sulforaphane helps heart muscle cells survive low-oxygen stress by boosting energy system and cell recycling communicationSulforaphane protects cardiomyoblasts against chemical hypoxia by increasing mitochondrial-ER communication and autophagy.

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4 weeks ago • Free radical biology & medicine

Blocking VDAC1 grouping may reduce brain damage after blood flow returns by boosting removal of damaged mitochondria through less interaction with LONP1Inhibiting VDAC1 oligomerization attenuated cerebral ischemia-reperfusion injury by promoting mitophagy via reduced LONP1 interaction.

🥉 Top 5% Journal

4 weeks ago • Neuroscience bulletin

Faulty Energy Producers in Brain Immune Cells May Cause Memory Decline and Brain Cell Damage Through Immune SignalingDysfunctional Mitochondria in Microglia Drive Cognitive Aging and Neurodegeneration via cGAS-STING.

🎖️ Top 10% Journal

4 weeks ago • Scientific reports

Biological age predicts spread and survival in gastrointestinal cancer differently depending on patient ageAge-dependent prognostic value of biological age for metastasis and survival in gastrointestinal cancer.

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4 weeks ago • American journal of physiology. Endocrinology and metabolism

Multiple biological changes linked to exercise in post-menopausal womenBridging the gap: Multi-omic Insights into Exercise Responses in Post-Menopausal Women.

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4 weeks ago • Autophagy

Restoring cell recycling to slow eye tissue breakdown by targeting the SNAI1-LAMP3 pathwayTargeting the SNAI1-LAMP3 axis to restore lysosomal function and alleviate autophagic flux impairment to delay retinal degeneration.

🥈 Top 2% Journal

4 weeks ago • Acta pharmacologica Sinica

Targeted protein breakdown connecting chemical biology and medical applicationsTargeted protein degradation: bridging chemical biology and clinical translation.

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1 month ago • Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Agmatine may boost cell cleaning processes to reduce gut cell death caused by sepsisAgmatine induces mitophagy via the PTS-I2R pathway to increase autophagic flux and attenuate sepsis-induced intestinal epithelial cell apoptosis.

🎖️ Top 10% Journal

1 month ago • Ageing research reviews

Using multiple biological measures and imaging to understand differences in organ aging for personalized elderly careFrom organ age gaps to precision geromedicine: Multi-omic and imaging frameworks for heterogeneous biological aging.

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1 month ago • ACS applied materials & interfaces

Using Tiny Droplets to Move Healthy Mitochondria into Aging Stem Cells to Reduce Cell AgingDroplet Microfluidics-Enabled Mitochondrial Transfer from Young to Senescent MSCs to Ameliorate Cellular Senescence.

🎖️ Top 10% Journal

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Longevity & Aging Research Papers