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1 month ago • GeroScience

How Long-Term Obesity and Genetic Risk Are Linked to Aging in Older Chinese AdultsThe impact of cumulative obesity and genetic susceptibility on biological aging in Chinese older adults.

🎖️ Top 10% JournalArticle

yesterday • Tissue & cell

How different cell death and cleanup processes interact in sudden pancreas inflammation and what this means for treatmentInterplay between mitophagy, ferroptosis, and pyroptosis in acute pancreatitis: Regulatory mechanisms and therapeutic implications.

📖 Top 30% JournalArticle

yesterday • Fitoterapia

Modified Hu-lu-ba-wan and trigonelline may improve diabetic kidney tubule damage by boosting mitochondrial quality control through PACS2-regulated contactsModified Hu-lu-ba-wan and its active component trigonelline ameliorate diabetic renal tubular injury via enhancing PACS2-regulated mitochondria-endoplasmic reticulum contacts and mitophagy.

📖 Top 50% JournalArticle

2 days ago • Archives of physiology and biochemistry

How Different Types of Exercise Affect Muscle TFEB Protein Movement Between Cell Nucleus and CytoplasmPost transcriptional modification regulation of skeletal muscle TFEB protein nuclear cytoplasmic transport based on different exercise modes in computer biomedical research.

📖 Top 30% JournalArticle

2 days ago • Aging

Reducing the enzyme Pla2g15 lowers certain fat molecules and aging signs in kidney cellsTargeting phospholipase Pla2g15 reduces long-chain BMP phospholipids abundance and senescence in kidney cells.

📖 Top 20% JournalArticle

2 days ago • Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics

Key Cellular Pathways May Trigger Inflammation in Eye Surface Cells Caused by Benzalkonium ChloridemTOR/Autophagy//NF-κB Axis Drives Benzalkonium Chloride-Induced Inflammatory Response in Corneal Epithelial Cells.

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2 days ago • Journal of visualized experiments : JoVE

Nerve damage linked to diabetes may cause digestive problemsDiabetes-Associated Enteric Neuropathy: An Overlooked Driver of Gastrointestinal Dysfunction.

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3 days ago • Molecular genetics and genomics : MGG

USP22 may reduce aging in bone marrow stem cells caused by oxidative stress by keeping SPI1 protein stableUSP22 alleviates oxidative stress-induced BMSCs senescence by stabilizing SPI1 protein.

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3 days ago • The international journal of biochemistry & cell biology

New Insights into Calcium Signals and Cell Recycling ProcessesAdvances in calcium transients and autophagy.

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3 days ago • International reviews of immunology

Aging immune system decline and organ communication problems: Possible benefits of algae-based compounds and nutrition for healthy agingImmunosenescence and immune-organ axis dysfunction: Potential of algal bioactives and nutritional interventions for healthy ageing.

📖 Top 20% JournalArticle

4 days ago • Fitoterapia

Huangqi Guizhi Wuwu decoction may reduce autoimmune nerve inflammation by helping cells clear damaged mitochondria and preventing brain immune cell deathHuangqi Guizhi Wuwu decoction suppresses experimental autoimmune encephalomyelitis by promoting PINK1/Parkin-mediated mitophagy and inhibiting microglial pyroptosis.

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5 days ago • Medical gas research

Nitric oxide signals and removal of damaged mitochondria in Parkinson's disease: possible links to brain protection from aerobic exerciseNitric oxide signaling and mitophagy in Parkinson's disease: implications for aerobic exercise-related neuroprotection.

📖 Top 30% JournalArticle

5 days ago • International urogynecology journal

Thrombospondin-1, a Stretch-Sensitive Protein, May Cause Aging in Support Cells Linked to Pelvic Organ ProlapseThrombospondin-1 as a Mechanosensitive Matrix Protein Driving Fibroblast Senescence: A Novel Pathogenic Target for Pelvic Organ Prolapse.

📖 Top 30% JournalArticle

1 week ago • Metabolic brain disease

Aldometanib boosts energy regulation to improve metabolism and thinking in aging miceAMPK activation by Aldometanib from Bigujing improves metabolic and cognitive dysfunction in aging mice.

📖 Top 20% JournalArticle

1 week ago • Neuroprotection (Chichester, England)

Using Antimicrobial Drugs to Protect the Brain: How They Work, Possible Benefits, and ChallengesRepurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges.

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1 week ago • Metabolic brain disease

Dihydromyricetin improves memory problems in aging mice by helping cells clear harmful inflammation complexesDihydromyricetin ameliorates cognitive dysfunction in SAMP8 mice via autophagy-mediated degradation of the NLRP3 inflammasome.

📖 Top 20% JournalArticle

1 week ago • Metabolic brain disease

How Obesity May Cause Blood-Brain Barrier Problems: Underlying Processes and Possible TreatmentsMolecular mechanisms of blood-brain barrier dysfunction caused by obesity: pathophysiological understandings and treatment targets.

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1 week ago • Metabolic brain disease

Nicotinamide riboside and metformin may protect the memory area of the brain in male rats with diet-related obesityNeuroprotective impact of nicotinamide riboside and metformin on the hippocampus of male rats with diet-induced obesity.

📖 Top 20% JournalArticle

1 week ago • Biochemical and biophysical research communications

Esculetin that targets cell energy centers may reduce age-related heart changes by activating energy and repair pathways and blocking stress signalsMitochondria-targeted esculetin mitigates age-associated cardiac remodeling through coordinated activation of AMPK-SIRT1 and inhibition of p38 MAPK signaling.

📖 Top 30% JournalArticle

1 week ago • Journal of molecular histology

Cell-level sirtuin signaling networks as key controllers of heart function and repairSubcellular sirtuin signaling networks: pivotal regulators of cardiovascular homeostasis and remodeling.

📖 Top 30% JournalArticle

1 week ago • Aging

How organisms with exceptionally long lifespans share common traitsHow to live for centuries: common denominators of organisms with exceptional longevity.

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1 week ago • Diabetes, metabolic syndrome and obesity : targets and therapy

Yiqi Huoxue Yangyin Decoction may improve diabetic kidney disease by regulating cell recycling through the AMPK/mTOR pathwayYiqi Huoxue Yangyin Decoction Ameliorates Diabetic Nephropathy by Targeting AMPK/mTOR-Mediated Autophagy: A Network Pharmacology-Guided in vivo and in vitro Study.

📖 Top 30% JournalArticle

1 week ago • Journal of the Formosan Medical Association = Taiwan yi zhi

Long-term seizure results and factors linked to response to added everolimus in epilepsy caused by tuberous sclerosis complexLong-term seizure outcomes and factors associated with response to adjunctive everolimus in TSC-associated epilepsy.

📖 Top 30% JournalArticle

1 week ago • Journal of visualized experiments : JoVE

Qi-fu-yin's effects on memory problems and brain cell aging in a mouse model of Alzheimer'sEffects of Qi-fu-yin on Improving Cognitive Impairment and Reducing Cellular Senescence in the Brains of 5xFAD Mice.

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1 week ago • Journal of molecular histology

Thymoquinone and intermittent fasting may protect rat memory areas from aluminum-induced Alzheimer's-like damage by affecting brain cell growth and cleanupThe neuroprotective potential of thymoquinone and intermittent fasting on aluminum chloride-induced Alzheimer's disease like model in rat hippocampus: insights into neurogenesis and autophagy.

📖 Top 30% JournalArticle

2 weeks ago • Journal of visualized experiments : JoVE

Bone Growth Effects, Unknown Mechanisms, and Safety of Nano-Pearl Powder and Water-Soluble Nacre ComponentsNano-Pearl Powder and Nacre-Derived Water-Soluble Matrix in Osteogenesis: Evidence, Mechanistic Gaps, and Safety Considerations.

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2 weeks ago • Biochemical and biophysical research communications

Ivermectin’s potential to affect a key protein pathway in Alzheimer’s diseaseTargeting the protein tyrosine phosphatase 1B signaling axis in Alzheimer's disease: Emerging therapeutic potential of ivermectin.

📖 Top 30% JournalArticle

2 weeks ago • The Orthopedic clinics of North America

Osteoarthritis as a Whole-Joint Disease: New Pain, Metabolism, Aging, and Repair Treatment Targets with Ideas for Personalized CareOsteoarthritis as a Whole-Joint Disease, Part II: Emerging Nociceptive, Metabolic, Senescence, and Regenerative Therapeutic Targets, with Perspectives on Precision Care.

📖 Top 30% JournalArticle

2 weeks ago • Journal of neuroimmunology

Nilotinib reduces inflammation and cell death in brain immune cells by controlling NF-κB signaling and boosting cell cleanup and membrane repairNilotinib attenuates NLRP3 inflammasome activation and GSDMD/NINJ1-mediated pyroptosis via modulation of NF-κB signaling and enhancement of BAG3-dependent aggrephagy and ESCRT-III-mediated plasma membrane repair in microglia.

📖 Top 20% JournalArticle

2 weeks ago • Food science and biotechnology

Broccoli, licorice, and passionflower mix may improve cell energy production and reduce aging-related damageBroccoli-licorice-passionflower blend improves mitochondrial function and exerts senotherapeutic effects.

📖 Top 30% JournalArticle

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Longevity & Aging Research Papers