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4 weeks ago • Neurochemical research

Desflurane raises key protein levels and lowers clock protein in memory areas, while Sorafenib reduces thinking problems in old miceDesflurane Increases Hippocampal RAF-MAPK-MSK1 Protein Levels and Reduces CLOCK Expression: Sorafenib Attenuates Cognitive Impairment in Aged Mice.

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4 weeks ago • Journal of molecular medicine (Berlin, Germany)

Overactive immune sensor in artery muscle cells worsens artery wall thickening in miceVascular smooth muscle-specific NLRP3 hyperactivation exacerbates arterial intimal hyperplasia in mice.

🎖️ Top 10% JournalArticle

4 weeks ago • American journal of hypertension

The NLRP3 Inflammasome as a Key Cellular and Mechanical Driver of Blood Vessel Changes in High Blood PressureBeyond Inflammation: The NLRP3 Inflammasome as a Cellular and Mechanical Hub of Vascular Remodeling in Hypertension.

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4 weeks ago • Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Faster Biological Aging Linked to Higher Risk of Early Colorectal Cancer in a Large East Asian GroupAccelerated Biological Aging and Risk of Early-Onset Colorectal Cancer: Findings from a Large Prospective East Asian Cohort.

🥈 Top 2% JournalArticle

4 weeks ago • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Sunitinib may cause removal of aging cells by changing a growth factor receptorSunitinib induces senolysis associated with modulation of platelet-derived growth factor receptor beta.

🎖️ Top 10% JournalArticle

yesterday • Tissue & cell

Interaction between cell cleanup and inflammatory death in osteoporosis: Connecting energy control to bone inflammationAutophagy-pyroptosis crosstalk in osteoporosis: Linking mitochondrial homeostasis to inflammatory bone remodeling.

📖 Top 30% JournalArticle

2 days ago • Journal of inflammation research

Mitochondrial Problems in Brain Diseases: Causes, New Findings, and Possible TreatmentsThe "Invisible Killer" of Neurodegeneration: Mitochondrial Dysfunction in Neurodegenerative Disorders, Mechanisms, Emerging Pathways and Therapeutic Strategies.

📖 Top 20% JournalArticle

3 days ago • Journal of visualized experiments : JoVE

Semi-Automated Analysis of Movement Health and Lifespan Using FlyTrDT in Fruit FliesSemi-Automated Integration of Motor Healthspan and Lifespan Analysis Using FlyTrDT Pipeline in Drosophila melanogaster.

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3 days ago • Molecular biology reports

Cell aging in heart valve disease: is treatment to remove aged cells possible?Cellular senescence in calcific aortic valve disease: are we ready for senolytic therapy?

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3 days ago • Journal of visualized experiments : JoVE

Cell Death Processes in Stroke: From How They Work to Possible TreatmentsMolecular Networks of Cell Death in Ischemic Stroke: From Mechanisms to Interventions.

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3 days ago • Medical science monitor : international medical journal of experimental and clinical research

Mitochondrial Splitting by Drp1 Helps Control Mineral Transport and Mitochondrial Balance During Bone FormationDrp1-Mediated Mitochondrial Fission Coordinates Mineral Precursor Transport and Mitochondrial Homeostasis During Osteogenesis.

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4 days ago • Molecular medicine reports

Mitochondria problems in fatty liver disease linked to metabolism: Causes and possible treatmentsMitochondrial dysfunction in metabolic dysfunction-associated steatotic liver disease: Mechanistic insights and therapeutic horizons (Review).

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5 days ago • Journal of biochemical and molecular toxicology

Stemonine may reduce skin cell aging caused by UVB light by activating a protective proteinStemonine Alleviates UVB-Induced Keratinocyte Senescence by Activating SIRT3.

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5 days ago • In vivo (Athens, Greece)

Urolithin A reduces noise-related hearing loss and is linked to increased cell cleanup in the earUrolithin A Attenuates Noise-induced Hearing Loss and Is Associated With Increased Cochlear Mitophagy Markers.

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6 days ago • Journal of visualized experiments : JoVE

Isolating Heart Muscle Cells from the Annual Killifish for Detailed Electrical RecordingIsolation of Ventricular Cardiomyocytes from the Annual Killifish Nothobranchius furzeri for Whole-Cell Patch Clamp Recordings.

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6 days ago • Journal of visualized experiments : JoVE

Long Non-Coding RNA H19 May Protect Diabetic Mice Hearts from Blood Flow Damage Through Low-Oxygen Response SignalingLong Non-Coding RNA H19 Protection Against Myocardial Ischemia/Reperfusion Injury in Diabetic Mice Through Hypoxia-Inducible Factor 1 Alpha Signaling.

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6 days ago • Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

Leukocyte Telomere Length and Telomerase Gene Variant Linked to Cannabis and Synthetic Cannabinoid Use DisorderExploring the Role of Leukocyte Telomere Length and Human Telomerase Reverse Transcriptase MNS16A Variant in Cannabis or Synthetic Cannabinoid Use Disorder.

📖 Top 20% JournalArticle

6 days ago • Cellular immunology

How aging changes the function of neutrophils in peopleEffect of aging on neutrophil function in humans.

📖 Top 20% JournalArticle

1 week ago • Cellular signalling

Moxibustion may help bone cell growth in osteoporotic rats by controlling stem cell signals that affect cell energy cleanupMechanistic study on the promotion of osteogenic differentiation in osteoporotic rats by moxibustion via regulation of BMSCs-derived exosomal miR-27a-3p-mediated mitophagy.

📖 Top 20% JournalArticle

1 week ago • Journal of Ayurveda and integrative medicine

How Rasayana may protect cells and support healthy agingMolecular mechanisms and therapeutic potential of Rasayana in cellular protection and healthy aging.

📖 Top 50% JournalArticle

1 week ago • Medical science monitor : international medical journal of experimental and clinical research

Thermosensitive Ion Channels and Their Possible Role in Diabetes and TreatmentReview of the Roles of Thermosensitive Transient Receptor Potential Channels in Diabetes Mellitus and Their Potential as Therapeutic Targets.

📖 Top 50% JournalArticle

1 week ago • Acta pharmaceutica (Zagreb, Croatia)

Relaxin-2 helps protect brain connections through inflammation and cell recycling pathways in the memory area in an age-related Alzheimer’s modelRelaxin-2 protects synaptic integrity via hippocampal NLRP3-mTOR-autophagy pathways in an age-dependent Alzheimer-like model.

📖 Top 50% JournalArticle

1 week ago • International journal of cosmetic science

Chemical and gene studies reveal multiple skin-aging benefits of a triple-fermented extractIntegrated chemical profiling, transcriptomics and functional validation elucidate the multifunctional benefits of a triple-ferment filtrate complex for skin aging intervention.

📖 Top 30% JournalArticle

1 week ago • Molecular biology reports

Saikosaponin A may help heal diabetic wounds by reducing inflammatory cell death and adjusting cell cleanup processesSaikosaponin A promotes diabetic wound healing by suppressing NLRP3 inflammasome-associated macrophage pyroptosis and modulating mitophagy-related signaling.

📖 Top 30% JournalArticle

1 week ago • Journal of visualized experiments : JoVE

Links, Causes, and Health Impacts of Eating Ultra-Processed Foods in Inflammatory Bowel DiseaseEpidemiological Evidence, Underlying Mechanisms, and Public Health Implications of Ultra-Processed Food Consumption in Inflammatory Bowel Disease.

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1 week ago • Molecular medicine reports

How Aging and Obesity Affect the Male Reproductive System and Ways to Manage ThemMechanisms of the interaction between aging of the male reproductive system and obesity, and clinical management strategies (Review).

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1 week ago • Journal of visualized experiments : JoVE

Ways to Measure How Caenorhabditis elegans Resist Different Types of StressMethods for Measuring Resistance to Multiple Stressors in Caenorhabditis elegans.

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1 week ago • Pulmonary pharmacology & therapeutics

Cell Aging and Blood Vessel Aging in Lung High Blood Pressure: Molecular Causes, Treatments, and Clinical MeasuresCellular senescence and vascular ageing in pulmonary hypertension: Molecular mechanisms, therapeutic strategies, and translational endpoints.

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1 week ago • Anesthesia and pain medicine

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1 week ago • Cardiovascular toxicology

How Air Pollution May Speed Up Heart and Blood Vessel Aging: Key Processes, Biomarkers, and the PACA ApproachParticulate Matter Exposure and Accelerated Cardiovascular Aging: Mechanistic Evidence, Biomarker Integration, and the PACA Framework.

📖 Top 30% JournalArticle

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Longevity & Aging Research Papers