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2 weeks ago • Metabolic brain disease

Changes in Fat Molecules Affecting Brain Cell Membranes in Obesity-Linked Alzheimer's Disease: How They Involve Immune Responses and Potential TreatmentsPhosphatidylethanolamine-mediated metabolic membrane remodeling in obesity-associated Alzheimer's disease: mechanisms, neuroimmune crosstalk, and therapeutic potential.

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2 weeks ago • Neuromolecular medicine

New Treatments to Restore α-Synuclein Removal in Parkinson's DiseaseRebalancing α-Synuclein Clearance: Novel Therapeutic Frontiers in Parkinson's Disease.

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2 weeks ago • Molecular carcinogenesis

Combined Genetic and Molecular Study of Aging-Related Genes Linked to Cancer RiskMulti-Omic Analysis of Putative Cellular Senescence-Associated Genes on the Risk of Pan-Cancer.

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3 weeks ago • Journal of molecular histology

Schisandra chinensis polysaccharide may reduce diabetic islet cell damage by boosting cell cleanup through blocking the PI3K/AKT/mTOR pathwaySchisandra chinensis polysaccharide attenuates diabetic islet cell injury by promoting autophagy via suppression of the PI3K/AKT/mTOR signaling cascade.

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3 weeks ago • Molecular biology reports

The PINK1-Parkin pathway’s role in removing damaged mitochondria during sepsis: helpful or harmful?PINK1-Parkin pathway-mediated mitophagy in sepsis: friend or foe?

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3 weeks ago • Metabolic brain disease

How different intensities of interval training affect brain cell cleanup, metabolism, and inflammation in rats with type 2 diabetesIntensity-dependent effects of interval training on brain mitophagy, metabolic signaling pathways, and neuroinflammation in a rat model of type 2 diabetes.

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3 weeks ago • Journal of inflammation research

How Inflammation and Metabolism Are Linked in Lung Function Impairment with Normal Breathing Ratios: Causes and Possible TreatmentsThe Inflammation-Metabolism Axis in Preserved Ratio Impaired Spirometry: Pathogenic Mechanisms and Translational Implications.

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3 weeks ago • The American journal of the medical sciences

Biological aging and faster aging linked to death risk in patients with heart and kidney problemsAssociations of biological aging and biological age acceleration with mortality in patients with cardiorenal syndrome: A prospective cohort study.

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3 weeks ago • Aging

Examining how aging may be linked to cell aging and DNA mutationsAssessing mechanisms and evidence of a causal role for cellular senescence and somatic mutations in aging.

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3 weeks ago • Molecular medicine reports

POU2F1 may promote high blood pressure-related heart scarring by controlling mitochondrial cleanup through PINK1/Parkin pathwaysPOU2F1 promotes hypertensive cardiac fibrosis by regulating mitochondrial homeostasis through PINK1/Parkin‑dependent mitophagy.

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3 weeks ago • Naunyn-Schmiedeberg's archives of pharmacology

Propofol may control nerve cell problems and excessive mitochondrial cleanup in the memory area after surgery in older adults by changing a gene regulatorPropofol regulates SLC6A2 expression via NAT10-mediated ac4C modification to modulate excessive mitophagy and hippocampal neuron dysfunction in aged postoperative cognitive dysfunction.

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3 weeks ago • Journal of cardiology

Heart muscle breakdown happens before scarring: the role of heart cell self-cleaning and its disease assessmentMyocardial degeneration precedes fibrosis: The role of myocardial autophagy and its pathological evaluation.

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3 weeks ago • Functional & integrative genomics

Identifying aging blood vessel cells in stroke using single-cell and bulk gene analysisDecoding the senescent endothelial landscape in ischemic stroke through single-cell and bulk RNA sequencing.

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3 weeks ago • Journal of applied toxicology : JAT

Planned Alcohol Use During Pregnancy and Its Impact on Offspring Heart Cell Cleanup Through TRPM2 Channels Linked to Fetal Alcohol Syndrome Heart ProblemsPlanned Ethanol Consumption in Pregnancy: Impact on Offspring Cardiac Autophagic Pathway via TRPM2 Channels-Implications for Fetal Alcohol Syndrome-Linked Cardiological Disorders.

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3 weeks ago • Physiological genomics

Mathematical Modeling of How Meal Timing and Protein Quality Affect the Liver's Daily Clock and Its Role in Making RibosomesMathematical Modeling of Dietary Timing- and Protein Quality-Responsive Liver Circadian Clock and its Function on Ribosome Biogenesis.

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3 weeks ago • Cell biochemistry and biophysics

How Imbalanced Cell Energy and Aging Processes Link to Blood-Brain Barrier Problems in Brain Aging and Neurodegenerative DiseasesThe Reductive Stress Nexus: Integrated Pathways of Metabolic Dysregulation, Senescence and Blood-Brain Barrier Failure in Neurodegenerative Disease and Brain Aging.

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3 weeks ago • Functional & integrative genomics

Key genes linked to cell aging and tissue changes in muscle loss identified by combined gene analysisIntegrated bulk and single-cell transcriptomic analyses identify senescence-related hub genes and microenvironmental remodeling in sarcopenia.

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3 weeks ago • Biochemical and biophysical research communications

Fibroblast activation protein promotes heart support cell activity linked to reduced cell cleanupFibroblast activation protein (FAP) promotes cardiac fibroblast activation in association with impaired ER-phagy.

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3 weeks ago • Neuroscience

Resveratrol improves liver failure-related thinking and movement problems in rats by affecting brain glutamate signalingSIRT1 activator resveratrol improves the ALF-induced cognitive and motor function deficits in rats via modulating glutamate-NMDAR-NOS-cGMP pathway.

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3 weeks ago • Aging

Blocking insulin signaling in worms greatly extends male lifespan and improves late-life reproductive healthDisruption of the insulin/IGF-1 signaling pathway in Caenorhabditis elegans dramatically increases male longevity and enhances reproductive health late in life.

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3 weeks ago • International journal of ophthalmology

Glucocorticoids may cause damage to retinal pigment cells linked to too much cell recycling and energy control signalsGlucocorticoid-induced RPE injury in ARPE-19 cells: association with excessive autophagy and AMPK/mTOR signaling.

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3 weeks ago • Cellular signalling

Mitochondria-linked processes in lung blood pressure disease: From changes in cell metabolism to blood vessel and heart damageMitochondria-centered signalling in pulmonary hypertension: From metabolic reprogramming to vascular remodeling and right ventricular failure.

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4 weeks ago • Biochemical and biophysical research communications

Low levels of a key receptor weaken the brain's protective barrier and speed up cell aging in the memory areaLow expression of PDGFR-β impairs the blood-brain barrier and accelerates cellular aging in the hippocampal region.

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4 weeks ago • Molecular biology reports

Icaritin may improve pregnancy chances in endometriosis by stopping aging in key ovarian cellsIcaritin improves pregnancy outcomes in endometriosis by inhibiting ovarian granulosa cell senescence.

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4 weeks ago • Molecular medicine reports

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4 weeks ago • Molecular medicine reports

How Cell Recycling Works and Its Treatment Potential in Intestinal Tissue ChangesAutophagy: Mechanisms and therapeutic perspectives in intestinal metaplasia (Review).

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4 weeks ago • Molecular biology reports

EGCG's role in controlling cell recycling to treat heart and blood vessel diseasesEGCG targeting autophagy in cardiovascular diseases: mechanisms and therapeutic potential.

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1 month ago • HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues

Using Biological Age Scores and the Risk of Age Bias in Algorithms: An Ethics Guide for OrganizationsBiological-Age Scoring and the Risk of Algorithmic Age Discrimination: An Institutional Ethics Framework.

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1 month ago • Stem cell reviews and reports

Problems in the Brain's Blood Vessel and Support System in Diabetic Eye Disease: From Molecular Causes to Targeted TreatmentsDysfunction of the Neurovascular Unit in Diabetic Retinopathy: Advances from Molecular Mechanisms to Targeted Interventions.

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2 days ago • Epigenomics

Epigenetic aging is not closely linked to fitness in heart failure patients: a pilot studyEpigenetic age acceleration is not strongly associated with cardiorespiratory fitness in heart failure: a pilot study.

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Longevity & Aging Research Papers