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1 week ago • Aging

From Overactive Processes to Widespread Boosts: Rethinking How Aging Can Be ReversedFrom hyperfunction to systemic amplification: reframing the logic of late-life rejuvenation.

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1 week ago • Immunobiology

Removing immune cells reduces inflammation and aging signs in old mouse kidneysPharmacological depletion of macrophages leads to a reduction in inflammation and senescence in aged murine kidneys.

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2 weeks ago • Odontology

Cell aging and its secretions in the mouth-body connection: a possible link between gum disease and type 2 diabetesCellular senescence and the SASP in the oral-metabolic axis: a putative link between periodontitis and type 2 diabetes mellitus.

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2 weeks ago • Discover nano

Using plant-based compounds to improve muscle loss by boosting mitochondrial cleanup and cell survivalTargeting ubiquitin-dependent mitochondrial autophagy and apoptosis in sarcopenia: the therapeutic potential of phytochemicals.

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2 weeks ago • Toxicology mechanisms and methods

Resveratrol's role in reducing reproductive damage: evidence and underlying mechanismsResveratrol as a Modulator of Reproductive Toxicity: Evidence and Mechanistic Perspectives.

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2 weeks ago • Journal of inflammation research

How Mitochondria and Immune Cells Interact During Sepsis at Different Stages: Linking Metabolic Changes, Organ Damage, and Treatment OptionsMitochondria-Macrophage Interactions in Sepsis at Different Immune Stages: Integrating Immunometabolic Reprogramming, Organ Damage, and Therapeutic Strategies.

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2 weeks ago • Aging

Key cell death genes linked to immune changes in Duchenne muscular dystrophy and their role in age-related muscle lossFerroptosis-related hub genes and immune infiltration characteristics in Duchenne muscular dystrophy: a molecular framework with implications for aging-related muscle degeneration.

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2 weeks ago • Molecular biology reports

Lack of Sirt3 weakens fat-blocking signals in female fat cellsSirt3 deficiency impairs AMPK-Acc1 antilipogenic signaling in female adipocytes.

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2 weeks ago • Journal of cardiovascular pharmacology

Targeting Aging Blood Vessel Muscle Cells for Heart and Blood Vessel Drug Treatments: How It Works and Possible TherapiesTargeting Vascular Smooth Muscle Cell Senescence for Cardiovascular Pharmacology: Mechanisms and Therapeutic Perspectives.

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2 weeks ago • Molecular biology reports

miR-486 reduces heart injury after blood flow returns by blocking cell death and self-cleaning through the FOXO1/PTEN/AKT/mTOR pathwaymiR-486 attenuates myocardial ischaemia/reperfusion injury by inhibiting apoptosis and autophagy activation via the FOXO1/PTEN/AKT/mTOR axis.

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2 weeks ago • Journal of reproductive immunology

High glucose levels may cause problems in placental cell invasion by increasing cell aging and IGFBP4 signalingElevated glucose levels trigger trophoblast cell invasion dysfunction through enhanced senescence and IGFBP4 signaling pathway.

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2 weeks ago • Metabolic brain disease

Resveratrol-enriched stem cell exosomes in a lab model of Parkinson’s diseaseExploring the potential of resveratrol-enriched cord mesenchymal stem cell derived exosomes in an in vitro Parkinson's model.

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3 weeks ago • Molecular genetics and genomics : MGG

HuR influences disease-related gene changes linked to Alzheimer's, including MAPTHuR modulates disease-relevant alternative splicing of MAPT and other Alzheimer's disease-related genes.

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3 weeks ago • Tissue & cell

Combined effects of resveratrol and nicotinamide on growth, cell death, and SIRT1 gene activity in human eye support cellsThe synergistic effects of resveratrol and nicotinamide on cell proliferation, apoptosis, and SIRT1 gene expression in human retinal pigment epithelial cells.

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3 weeks ago • Current drug targets

Computer Study of Hydnocarpin as a New ROCK2 Blocker and Possible Controller of Cell Cleanup in CancerComputational Evaluation of Hydnocarpin as a Novel ROCK2 Inhibitor and Potential Regulator of Mitophagy in Cancer.

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3 weeks ago • American journal of lifestyle medicine

Using Lifestyle Changes to Improve Health in People with Intellectual and Developmental DisabilitiesApplying Lifestyle Medicine to Improve Health Outcomes in People With Intellectual and Developmental Disabilities.

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3 weeks ago • Aging

Multiple Aging Processes with Epigenetic Control as a Key Limit to Human LifespanThe polycentric aging framework: epigenetic regulation as a dominant lifespan-limiting center in human aging.

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3 weeks ago • Biochemical and biophysical research communications

Targeting tau protein acetylation in Alzheimer's disease: how it works, its harmful effects, and possible treatments from plant-based compoundsTargeting tau acetylation in Alzheimer's disease: Molecular mechanisms, pathological consequences, and therapeutic opportunities of dietary phytochemicals.

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3 weeks ago • Neuroscience

Humanin reduces brain cell aging and keeps nerve signal release stable in mature nerve-like cellsHumanin attenuates neuronal cellular senescence and preserves neurotransmitter release in differentiated PC12 cells.

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3 weeks ago • Molecular biology reports

Oxidized mitochondrial DNA as a possible marker and cause of disrupted cell cleanup in pulmonary arterial hypertensionOxidized mitochondrial DNA as a potential biomarker and mechanistic driver of autophagy-mitophagy dysregulation in pulmonary arterial hypertension: a narrative review.

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3 weeks ago • Toxicology mechanisms and methods

Metformin partly reduces nerve cell aging caused by cisplatin but does not stop increased sensitivity in rat peripheral nervesMetformin Partially Modulates Cisplatin-Induced Neuronal Senescence but Does Not Prevent Rat Peripheral Sensory Hypersensitivity.

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3 weeks ago • Advances in biological regulation

Differences and roles of two main systems that clear damaged cell powerhousesBNIP3/NIX-mediated mitophagy versus Parkin-mediated mitophagy: mechanistic differences and functional implications.

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3 weeks ago • Aging

Small cell-released particles may carry aging signals to nearby cells in lab modelsSmall extracellular vesicles as mediators of paracrine senescence in cellular models of aging.

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3 weeks ago • Mitochondrion

Purine levels affect survival of cells lacking energy complex I when relying on oxidative energy productionPurine availability determines survival of complex I-deficient fibroblasts under OXPHOS-reliant condition.

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4 weeks ago • Molecular biology reports

Mitochondria problems in kidney tubule cells linked to scarring and tissue changes in chronic kidney diseaseMitochondrial dysfunction of renal tubular epithelial cells in chronic kidney disease-associated fibrosis: from organelle homeostasis to multicellular remodeling.

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4 weeks ago • Journal of biochemical and molecular toxicology

Kidney Tubular Cell Aging Caused by 1-Aminopyrene May Activate Fibroblasts Through BRD4-Linked Aging-Related SignalsRenal Tubular Epithelial Cells Senescence Induced by 1-Aminopyrene Activates Fibroblast via BRD4 Driven Senescence-Associated Secretory Phenotype Signaling.

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4 weeks ago • Journal of cellular biochemistry

Chronic Stress May Worsen Bone Loss in Mice Without Ovaries Showing Anxiety and Depression by Activating Bone Breakdown and Blocking Cell CleanupChronic Stress Exacerbates Osteoporosis in Ovariectomized Mice With Anxiety- and Depression-Like Symptoms by Activating Cathepsin K and Impairing Autophagy.

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4 weeks ago • Molecular reproduction and development

Jujuboside A may improve polycystic ovary syndrome by boosting cell cleanup in ovarian support cells through SIRT3 and PINK1/Parkin pathwaysJujuboside a Improves Polycystic Ovary Syndrome Through SIRT3-Mediated PINK1/Parkin-Dependent Mitochondrial Autophagy in Ovarian Granulosa Cells.

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4 weeks ago • Journal of the Endocrine Society

Angiotensin II and cAMP signals control the creation and function of energy-producing parts in human adrenal gland cellsAngiotensin II and cAMP signaling pathways regulate mitochondrial biogenesis and activity in human adrenocortical cells.

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4 weeks ago • Regenerative therapy

Stem cell aging limits bone and joint repair in aging: underlying processes and possible treatmentsStem cell senescence as a regenerative bottleneck in age-related skeletal degeneration: Mechanistic crosstalk and translational strategies.

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Longevity & Aging Research Papers