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4 weeks ago • Acta neurologica Belgica

Shorter immune cell DNA length as a sign of aging in relapsing-remitting multiple sclerosisShorter Leukocyte telomere length as a marker of biological aging in relapsing-remitting multiple sclerosis.

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1 month ago • Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

How Cell Recycling and Gene Regulation in Brain Hunger Centers May Explain Ongoing Obesity and Treatment ChallengesThe Autophagy-Epigenome Axis in Hypothalamic Neurons: A Unified Framework for Understanding Obesity Persistence and Therapeutic Resistance.

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1 month ago • Cellular signalling

A protective feedback loop helps lung cells resist aging and harmful changes caused by inorganic arsenicp62-Keap1-Nrf2 positive feedback loop protects against inorganic arsenic-induced senescence and EMT in alveolar type II cells.

📖 Top 20% JournalArticle

2 days ago • Herz

Can Age Be Changed to Lower Heart Disease Risk?Age: a modifiable risk factor for cardiovascular disease?

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4 days ago • Current medical science

Using Lipid-Based Drugs to Target Aging Fat Cells for Treating Metabolic DiseasesIntervening in Adipocyte Senescence: Lipid Prodrugs as an Emerging Strategy for Metabolic Disease Treatment.

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1 week ago • JMIR dermatology

Using AI to Grade Facial Aging Signs and Estimate Visible Age from Standard PhotosAI-Based Grading of Facial Aging Signs and Prediction of Visible Age From Standardized Facial Images: Algorithm Development and Internal Evaluation Study.

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1 week ago • Cytotechnology

CDKN1B forms liquid droplets and reduces fat buildup and inflammation by boosting damaged mitochondria removal in non-alcoholic fatty liver diseaseCDKN1B undergoes liquid-liquid phase separation and attenuates lipid accumulation and inflammatory response by promoting mitophagy in non-alcoholic fatty liver disease.

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1 week ago • IBRO neuroscience reports

Protective effects of Klotho signals in Huntington's disease from molecules to treatmentNeuroprotective roles of Klotho signaling in Huntington's disease: From molecular insights to clinical translation.

📖 Top 30% JournalArticle

2 weeks ago • International journal of stem cells

TAOK1 may protect older mice from kidney injury after blood flow returns by activating a cell cleanup processTAOK1 Protects against Renal Ischemia-Reperfusion Injury in Aged Mice through the STK3/BNIP3 Mitophagy Pathway.

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2 weeks ago • Stem cell research

Creating a human stem cell line with controllable p16INK4a gene activation using doxycyclineEstablishment of a doxycycline-inducible p16INK4a knock-in human embryonic stem cell line, WAe009-A-3Y.

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3 weeks ago • Journal of bioenergetics and biomembranes

APPL1 reduces DHEA-caused cell damage in ovarian support cells by improving mitochondrial cleanup and preventing iron-related cell death: implications for polycystic ovary syndromeAPPL1 attenuates DHEA-induced oxidative injury in granulosa cells by enhancing mitophagy and suppressing ferroptosis: implications for polycystic ovary syndrome.

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3 weeks ago • Mechanobiology in medicine

Using Joint Tissue Mechanics in Osteoarthritis to Develop Better Material-Based TreatmentsTranslating mechanobiology in osteoarthritis to biomaterial-informed therapeutic strategies.

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2 weeks ago • Molecular and cellular biochemistry

Disrupted body clocks worsen alcohol-related heart damage by harming cell cleanup and increasing heart cell deathCircadian disruption exacerbates alcohol-induced cardiac injury through impaired cellular quality control and increased cardiomyocyte death.

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3 weeks ago • JAMA

Nicotinamide Riboside Treatment in Early Parkinson’s Disease: A Randomized Clinical TrialNicotinamide Riboside for Patients With Early-Stage Parkinson Disease: The NOPARK Randomized Clinical Trial.

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3 weeks ago • Science (New York, N.Y.)

Changes in gene regulation and DNA elements linked to shorter lifespans in larger dogsEpigenetic aging and transposon dysregulation reflect size-related lifespan compression in dogs.

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5 days ago • Nature

Diet at the start of disease affects how tissues remember inflammationDiet at disease onset determines tissue inflammatory memory.

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6 days ago • Brain : a journal of neurology

E3 ubiquitin ligases: key proteins for protein balance affected in inherited nerve disordersE3 ubiquitin ligases: a vital component of proteostasis impaired in hereditary neuropathies.

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1 week ago • Genetics and molecular biology

Active Vitamin D supports bone cell precursor recycling and development by increasing BECN1 gene activity1α,25-(OH)2-D3 promotes osteoclast-precursor autophagy and osteoclast differentiation by promoting BECN1 transcription.

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1 week ago • Gerontology

Links Between Oxidative Balance and Biological Aging, and Possible Roles of Inflammation and Cholesterol Ratios in US AdultsAssociation of the Oxidative Balance Score with GOLD BioAge: Potential Mediating Roles of SIRI and UHR among US Adults.

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1 week ago • Clinical science (London, England : 1979)

The AIM2 immune sensor is linked to age-related heart problems after blood flow returns in miceThe AIM2 inflammasome drives age-dependent cardiac dysfunction following ischemia-reperfusion in mice.

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1 week ago • EMBO reports

Lck controls T cell activation by modifying p62Lck regulates T cell activation through phosphorylation of p62.

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2 weeks ago • FASEB journal : official publication of the Federation of American Societies for Experimental Biology

A protein in blood vessel cells may reduce cell aging and fat buildup to protect against artery disease in miceEndothelial Matrin-3 Limits Cellular Senescence and Lipid Dysregulation to Protect Against Murine Atherosclerosis.

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2 weeks ago • iMetaOmics

Biological Age and How Activity, Sleep, and Diet Together Influence Healthy AgeingBiological age in the meta omics era: Integrating physical activity, sleep, and diet to reshape paths of healthy ageing.

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2 weeks ago • Proceedings of the National Academy of Sciences of the United States of America

S-adenosyl-L-homocysteine may extend lifespan by activating a protective response through the YBT1 transporterS-adenosyl-L-homocysteine triggers an adaptive response that extends lifespan through the YBT1 ABC transporter.

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3 weeks ago • Autophagy reports

TRPML3 and TRPML1/3 differently control unusual MIF release through TMED10 and secretory autophagyTRPML3 and TRPML1/3 differentially regulate unconventional MIF secretion through TMED10 and secretory autophagy.

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3 weeks ago • Diabetes, obesity & metabolism

Cell Recycling Controls Foxo1 Protein Levels to Regulate Liver Glucose Production in Response to GlucagonAutophagy Regulates Foxo1 Protein Abundance to Control Hepatic Glucose Production in Glucagon Signalling.

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3 weeks ago • Phytotherapy research : PTR

Epigallocatechin-3-Gallate may protect mice from fructose-related fatty liver by controlling cell death and recycling through SIRT5Protective Effect of Epigallocatechin-3-Gallate Against Fructose-Induced Metabolic Associated Fatty Liver Disease in Mice by Regulating Ferroptosis and Autophagy via SIRT5.

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3 weeks ago • Journal of neurochemistry

Balance of Synapse Maintenance in Health and IllnessSynaptic Proteostasis in Health and Disease.

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3 weeks ago • Autophagy reports

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4 weeks ago • Brain : a journal of neurology

Mitochondrial DNA damage may increase PINK1 levels in movement-related brain neurons in Parkinson's diseaseMitochondrial DNA damage elicits PINK1 upregulation in pontine cholinergic neurons in Parkinson's disease.

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Longevity & Aging Research Papers