OpenScience.ink

3 days ago • Restorative neurology and neuroscience

Resveratrol supports memory area energy function and prevents nerve cell damage to improve thinking problems linked to diabetes through Sirt1/Shh signalingResveratrol Maintains Hippocampal Mitochondrial Function and Inhibits Neuronal Ferroptosis to Improve Diabetes-Associated Cognitive Dysfunction via Sirt1/Shh Signaling.

📖 Top 50% JournalArticle

1 week ago • Annals of human genetics

Genetic Links Between White Blood Cell Telomere Length, Faster Biological Aging, and HealthspanGenetically Proxied Leukocyte Telomere Length and Epigenetic Age Acceleration in Relation to Healthspan: A Mendelian Randomization Study.

📖 Top 50% JournalArticle

2 weeks ago • International journal of rheumatic diseases

Faster Biological Aging and Its Link to Osteoarthritis Risk Over TimeCross-Sectional and Longitudinal Association Between Biological Aging Acceleration and the Risk of Osteoarthritis: A Cohort Study From UK Biobank.

📖 Top 50% JournalArticle

2 weeks ago • Chemistry & biodiversity

Egg Peptides from American Shad May Extend Lifespan and Health in Worms by Changing Fat Metabolism and Boosting Antioxidant DefensesEgg Peptides From American Shad Extend Lifespan and Healthspan in Caenorhabditis elegans via Lipid Metabolism Remodeling and Antioxidant Defense.

📖 Top 50% JournalArticle

3 weeks ago • Omics : a journal of integrative biology

Large-Scale Study of Cell Protein Phosphorylation Suggests a Role for LPIN1 S162 in Metabolic SignalingLarge-Scale Cellular Phosphoproteomic Analysis Reveals a Putative Role for LPIN1 S162 in Metabolic Signaling.

📖 Top 50% JournalArticle

3 weeks ago • Bio Systems

Ageing as a Thermodynamic Phase Change: Entropy Production and an Update to Strehler's PrinciplesThe Thermodynamic Phase Transition Hypothesis of Ageing: Entropy Production and a Proposed Extension to Strehler's Postulates.

📖 Top 50% JournalArticle

1 month ago • Zhen ci yan jiu = Acupuncture research

Electroacupuncture’s effects on liver cell recycling in obese mice through energy and growth regulation pathways[Effect of electroacupuncture on hepatic autophagy in obese mice based on the AMPK/mTOR/ULK1 pathway].

English Abstract

1 month ago • Bio Systems

Aging as Increasing Blockages Across Key Processes: A Mathematical Model of Repair Limits, Cell Aging, Inflammation, and Failed RegenerationAging as cross-hallmark obstruction amplification: A sheaf-theoretic model of repair closure, senescence, inflammation, and regenerative failure.

📖 Top 50% JournalArticle

5 days ago • Orthopadie (Heidelberg, Germany)

Biological Age in Orthopedics: Why It Matters, How to Measure It, and Clinical Advice[Biological age in orthopedics : Importance, assessment, and clinical recommendations].

English Abstract

5 days ago • Methods in molecular biology (Clifton, N.J.)

Features of Aging-Related Secretions in Natural and Lab-Grown Skin Cells Using Multiple TestsCharacterization of the Senescence-Associated Secretory Phenotype in Primary and Induced Pluripotent Stem Cell-Derived Skin Cells via Multiplex Assays.

📖 Top 50% JournalArticle

3 weeks ago • Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

Traditional Chinese Herbal Formula YA3D3 Improves Alzheimer’s-Like Brain Changes and Memory Problems in a Mouse ModelTraditional Chinese Herbal Formula YA3D3 Ameliorates Alzheimer's Disease-Like Pathology and Cognitive Impairment in APP/PS1 Transgenic Mice.

Article

1 week ago • Cardiovascular drugs and therapy

Changes in Sugar Metabolism in Immune and Blood Vessel Cells Linked to AtherosclerosisVascular Immunometabolism in Atherosclerosis: Emerging Roles of Glycometabolic Reprogramming in Immune and Vascular Cells.

Systematic Review

3 weeks ago • International journal of chronic obstructive pulmonary disease

Biological age linked to risk of death from any cause in COPD patientsPredictive Value of Biological Age for All-Cause Mortality in Patients with COPD.

Comparative Study

3 weeks ago • Basic & clinical pharmacology & toxicology

Low-dose fisetin supplements and their link to long-term inflammation in middle-aged and older adultsLow-Dose Fisetin Supplementation and Its Association With Chronic Inflammation in Middle-Aged and Older Adults: Study Protocol for a Triple-Blind, Randomised, Placebo-Controlled Trial.

Randomized Controlled Trial

1 month ago • bioRxiv : the preprint server for biology

The longevity-linked enzyme UBE3C controls lamin B1 levels by selective cell recycling and slows agingA longevity-associated ubiquitin E3 ligase UBE3C governs lamin B1 homeostasis through selective autophagy and delay senescence.

Preprint

5 days ago • Experimental physiology

Removing aging heart cells improves age-related heart changes in miceClearance of p16-positive cardiac cells improves age-related cardiac remodeling in mice.

Fulltext (Open License)Article

1 month ago • bioRxiv : the preprint server for biology

Genetic factors linked to protein changes over time in large health study groupsGenetic drivers of protein changes over time: Findings, considerations, and approaches in TOPMed cohorts and UK Biobank.

Preprint

2 weeks ago • Mechanisms of ageing and development

Metformin treatment may increase immune cell aging markers and longevity genes in Asian Indians with prediabetes over 24 weeksMetformin therapy increases leukocyte telomere length, telomerase activity, and longevity gene expression in Asian Indians with prediabetes: A 24-week participant-blind, outcome-assessor-blinded randomized controlled trial.

Article

3 weeks ago • The journals of gerontology. Series A, Biological sciences and medical sciences

Biological Age Linked to Long-Term Decline in Frailty-Related AbilitiesBiological Age Associates with Longitudinal Frailty-Related Functional Decline: The Health and Retirement Study.

Article

3 days ago • Autophagy reports

Complex interactions between the cell’s DNA-sensing system and its recycling processMultilayered interplay between the cGAS-STING pathway and autophagy.

Article

1 week ago • Phytotherapy research : PTR

Research trends and key insights into natural treatments for Alzheimer's diseaseResearch Trends and Mechanistic Insights Into Natural Medicines for Alzheimer's Disease: A Bibliometric Analysis and Narrative Review.

Article

1 week ago • FASEB journal : official publication of the Federation of American Societies for Experimental Biology

SIRT1's Role, Importance, and Treatment Potential in Brain Degenerative DiseasesSIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential.

Article

1 week ago • Clinical science (London, England : 1979)

Activating Beclin1 by Genes or Drugs May Prevent Heart and Blood Vessel Damage Caused by AldosteroneGENETIC AND PHARMACOLOGIC ACTIVATION OF BECLIN1 PREVENTSALDOSTERONE-INDUCED CARDIOVASCULAR DAMAGE.

Article

2 weeks ago • Smart molecules : open access

A pH-sensitive fluorescent probe shows how a key enzyme groups together to help cells avoid agingA pH-Responsive fluorescence lifetime probe reveals GOT1 phase separation in cellular anti-senescence.

Article

2 weeks ago • Clinical science (London, England : 1979)

Lack of IRAP helps protect kidney function and reduce damage in older miceIRAP deficiency preserves renal function and attenuates pathology in aged mice.

Article

3 weeks ago • Experimental physiology

How Cold-Water Recovery Can Both Boost Relaxation and Pain Relief but Slow Muscle Growth Over TimeThe cold-water immersion recovery-adaptation paradox: Reconciling acute parasympathetic and analgesic benefits with chronic hypertrophy attenuation.

Article

3 weeks ago • Genetics and molecular biology

Mitochondria’s role in immune response and treatments during long COVIDMitochondria in SARS-CoV-2 infection: Immune interactions and molecular approaches in the Post COVID-19 condition.

Article

3 weeks ago • Archives of toxicology

Liver growth linked to Pregnane X receptor activation in healthy people and the role of AKT-MTOR pathway in micePregnane X receptor-mediated liver growth: a controlled clinical trial in healthy volunteers and identification of the role of AKT-MTOR pathway in mouse.

Article

4 weeks ago • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Understanding and Managing the Combined Loss of Bone and MuscleOsteosarcopenia Revisited: From Mechanisms to Management.

Article

4 weeks ago • Nature medicine

How aging biomarkers respond to life-extending treatments in peopleResponsiveness of epigenetic aging biomarkers to longevity interventions in humans.

Article

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Longevity & Aging Research Papers